Cancer Science Institute of Singapore
Dr. Sudhakar Jha is a Principal Investigator at Cancer Science Institute of Singapore, and Assistant Professor in Department of Biochemistry, YLL School of Medicine at the National University of Singapore. He is interested in understanding the regulation of chromatin remodeling complexes and their role in cancer prevention and intervention. Chromatin remodeling complexes play an important role in maintaining chromatin organization as they create a histone code that is read by specific readers resulting in an active or repressed chromatin. He has purified and characterized chromatin remodeling complexes implicated in transcription and DNA damage response (Mol Cell 2009, 34: 521-533). He has identified the role of TIP60, a histone acetyltransferase in DNA damage response pathway (Mol Cell Biol 2008, 28: 2690-2700) and RVB1, a component of TIP60 complexes to be required for activity of this complex (Mol Cell Biol 2013, 33: 1164-74). Following which, he discovered Human Papillomavirus (HPV) E6 and Adenovirus (AdV) oncogenes to destabilize TIP60 (Mol Cell 2010, 38: 700-711 and Oncogene 2013, 32: 5017-25).