PROGRAM

6 November 2017, Monday

9.30am – 10.30am

Registration and Arrival of Guests

10.30am – 10.35am

Opening Address

10.35am – 10.40am

Welcome Address

SESSION 1

ONG Sin Tiong, Duke-NUS Medical School, Singapore

10.40am – 11.20am

Stephen WEST
Senior Group Leader, Francis Crick Institute, UK

Unresolved Recombination Intermediates as a Source of DNA Breaks and Chromosome Aberrations

11.20am – 11.40am

Anand D JEYASEKHARAN
Associate Consultant, Department of Haematology-Oncology, National University Hospital, Singapore
Principal Associate, Cancer Science Institute of Singapore, National University of Singapore

A Link between Proliferative Capacity and Homologous Recombination in Cancer

11.40am – 12.20pm

Raghu KALLURI
Chairman and Professor, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, USA

The Functional Role of Tumor Stroma and Exosomes in Biology and Treatment of Pancreatic Cancer

12.20pm – 1.20pm

LUNCH

12.50pm – 1.20pm

POSTER SESSION

1.20pm – 2.00pm

Rong LI
Bloomberg Distinguished Professor of Cell Biology, Johns Hopkins School of Medicine, USA

The Impact of Karyotype Heterogeneity on Evolutionary Adaptation to Stress: From Experiments to Theory

2.00pm – 2.10pm

ORAL PRESENTATION

2.10pm – 2.30pm

Jonathan LOH
Senior Principal Investigator, Institute of Molecular and Cell Biology, Singapore

Single-Cell Analysis of Call-Fate Transformation and Cancer

2.30pm – 3.10pm

FENG Gen-Sheng
Professor, Department of Pathology, University of California, San Diego, USA

Deciphering the Anti-Oncogenic Effects of Oncoproteins in Liver Cancer

3.10pm – 3.40pm

TEA BREAK & POSTER SESSION

SESSION 2

Sudhakar JHA, Cancer Science Institute of Singapore, NUS

3.40pm – 4.00pm

CHNG Wee Joo
Director, National University Cancer Institute, Singapore
Deputy Director and Senior Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore

Non-Canonical Roles of EZH2

4.00pm – 4.40pm

Mark DAWSON
Head, Haematology Cancer Therapeutics Program and Cancer Epigenetics Laboratory, Professor of Medicine, Peter MacCallum Cancer Centre, Australia

Molecular Mechanisms Governing Sensitivity and Resistance to Epigenetic Therapies

4.40pm – 4.50pm

ORAL PRESENTATION

4.50pm – 5.10pm

Hyungwon CHOI
Adjunct Principal Investigator, Institute of Molecular and Cell Biology, Singapore
Associate Professor, Saw Swee Hock School of Public Health, National University of Singapore

Pan-cancer Analysis of Exome Sequence Variants and Other Multi-Omics Data in the Cancer Genome Atlas

5.10pm – 5.50pm

Danny REINBERG
Terry and Mel Karmazin Professor of Biochemistry and Molecular Pharmacology, New York University School of Medicine, USA

Epigenetics: One Genome, Multiple Phenotypes

7 November 2017, Tuesday

SESSION 3

Vinay TERGAONKAR, Institute of Molecular and Cell Biology, Singapore

9.30am – 10.10am

Jean ZHAO
Professor in Cancer Biology, Dana-Farber Cancer Institute, USA

Targeting Therapeutic Resistance in Cancer: From Mouse Models to Human Therapy

10.10am – 10.30am

WANG Xiaomeng
Assistant Professor and Principal Investigator, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

The Role of LRG1-regulated TGFβ Signaling Pathway in Skin Cancer

10.30am – 10.40am

ORAL PRESENTATION

10.40am – 11.00am

Giulia RANCATI
Senior Principal Investigator, Institute of Medical Biology, A*STAR, Singapore

Hyperthermia Induces Mitotic Slippage and Genome Doubling in Colorectal Cancer Cell Lines

11.00am – 11.30am

TEA BREAK & POSTER SESSION

11.30am – 11.50am

Shyam PRABHAKAR
Senior Group Leader and Associate Director, Integrative Genomics, Genome Institute of Singapore

Single Cell Tumor Transcriptomics

11.50am – 12.30pm

Michael T HEMANN
Associate Professor of Biology, Massachusetts Institute of Technology, USA

Overcoming Resistance to Cancer Therapy

12.30pm – 12.50pm

Dennis KAPPEI
Senior Research Scientist and Special Fellow, Cancer Science Institute of Singapore, National University of Singapore

From Protein Evolution to Novel Telomere Length Regulators

12.50pm – 2.20pm

LUNCH    ||    LUNCH WITH THE EXPERTS

1.20pm – 2.20pm

POSTER SESSION 2

SESSION 4

TAM Wai Leong, Genome Institute of Singapore

2.20pm – 2.40pm

ONG Choon Kiat
Principal Investigator, Division of Medical Oncology National Cancer Centre Singapore

Mechanism of Immune Checkpoint Blockade in Natural Killer/T-cell Lymphoma

2.40pm – 2.50pm

ORAL PRESENTATION

2.50pm – 3.30pm

Shizuo AKIRA
Director and Professor, Laboratory of Host Defense, WPI Immunology Frontier Research Centre, Osaka University, Japan

Identification of a Monocyte Subset Responsible for Lung Fibrosis

3.30pm – 3.50pm

ZHAI Weiwei
Senior Research Scientist, Genome Institute of Singapore

The Level of Tumor Heterogeneity and Evolutionary Trajectories in Hepatocellular Carcinoma

3.50pm – 4.20pm

TEA BREAK & POSTER SESSION

4.20pm – 4.40pm

Yvonne TAY
Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore

MicroRNA-638 Regulates Tumorigenesis in Prostate Cancer Via a FTH1 gene:pseudogene Network

4.40pm – 5.20pm

Ulrich STEIDL
Diane and Arthur B. Belfer Faculty Scholar in Cancer Research, Professor of Cell Biology and Medicine (Oncology), Albert Einstein College of Medicine, USA

Molecular Mechanisms and Targeting of Pre-Cancerous Stem Cells

5.20pm – 5.40pm

David EPSTEIN
Associate Dean of Research, Duke-NUS Medical School, Singapore

Defective RNA Splicing and How It Can Drive Tumor Growth

8 November 2017, Wednesday

SESSION 5

Caroline LEE, National Cancer Centre Singapore

9.30am – 10.10am

Jeff WRANA
Professor, University of Toronto, Canada
Senior Principal Investigator, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada

The Hippo-TGFbeta-WNT Signaling Axis in Tissue Biology and Disease

10.10am – 10.30am

Kanaga SABAPATHY
Principal Investigator and Head, Division of Cellular and Molecular Research, National Cancer Centre Singapore
Professor, Duke-NUS Medical School, Singapore

New Tools for Detecting and Targeting Mutant p53

10.30am – 10.50am

David LANE
Chief Scientist, A*STAR, Singapore

Stapled Peptide Activation of p53

10.50am – 11.20am

TEA BREAK

11.20am – 12.00pm

Ann Marie PENDERGAST
Anthony R. Means Cancer Biology Professor and Vice Chair of Pharmacology and Cancer Biology, Duke University School of Medicine, USA

Kinase Signaling Networks Promote Lung Cancer Progression and Metastasis

12.00pm – 12.10pm

ORAL PRESENTATION

12.10pm – 12.30pm

Koji ITAHANA
Associate Professor, Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore

Targeting the Novel Glucose-Sensing Mechanism in Cancer

12.30pm – 2.05pm

LUNCH

SESSION 6

GOH Boon Cher, National University Cancer Institute, Singapore

2.05pm – 2.45pm

CHEN Ye-Guang
Professor, School of Life Sciences, Tsinghua University, China

Cooperation between TGF-β Signalling and HER2/EGFR Signalling Promotes Breast Cancer Development

2.45pm – 3.05pm

TOH Han Chong
Deputy Director, Senior Consultant and Principal Investigator, National Cancer Centre Singapore

Awakening the Immune System Against Cancer – Coming to a Clinic Near You

3.05pm – 3.45pm

Laura SOUCEK
Principal Investigator, Vall d’Hebron Institute of Oncology (VHIO), Spain

Targeting the Undruggable: Inhibiting Myc with Omomyc-derived Peptides

3.45pm – 4.15pm

TEA BREAK

4.15pm – 4.25pm

ORAL PRESENTATION

4.25pm – 5.05pm

Xi HE
American Cancer Society Professor, Boston Children’s Hospital, USA

Understanding Wnt Signaling in Development, Stem Cells, and Cancer

5.05pm – 5.45pm

Roeland NUSSE
Virginia and Daniel K. Ludwig Professor in Cancer Research, Professor of Developmental Biology, Stanford University, USA

Wnt Signaling and Stem Cells

5.45pm – 5.55pm

Announcement of Results and Prize Presentation

5.55pm – 6.00pm

Closing Address