Genome Institute of Singapore

Shyam Prabhakar obtained a B.Tech in Electronics and Communications Engineering from the Indian Institute of Technology, Madras and a PhD in Applied Physics from Stanford University. He was sole recipient of the American Physical Society thesis award for Beam Physics in 2001. Following a postdoctoral fellowship under Eddy Rubin at the Lawrence Berkeley National Laboratory, he started his own research group at the Genome Institute of Singapore (GIS). The Prabhakar lab uses single-cell RNA-seq, cohort-scale ChIP-seq and other high-throughput assays, together with algorithm development, to uncover markers and molecular mechanisms of human diseases. Major achievements include the first single-cell transcriptomic analysis of colorectal cancer, the first large-scale screen for disease-causing genetic variants that affect histone acetylation, the first histone acetylome-wide association study of a psychiatric disorder and the first unified signal-processing method for peak detection in NGS data. Dr. Prabhakar is currently Associate Director of Integrative Genomics and GIS lead for the centre for Big Data and Integrative Genomics (c-BIG).