Work in the ADJ laboratory focuses on identifying molecules and pathways that modulate the immune response after DNA damage, specifically in the context of genotoxic chemotherapy in cancer. Our eventual aim is to use this information to guide the rational design of immunotherapy-chemotherapy combinations for cancer treatment. The immune response to DNA damage is relevant to both epithelial and non-epithelial cancers, and we use a variety of cancer models in our research. We however have a specific interest in lymphomas, on account of my clinical practice as a medical oncologist on the NUH Lymphoma team. Alongside fundamental research on DNA damage and the immune response, the ADJ lab has a translational component that interfaces with clinical teams (lymphoma, gastro-intestinal and gynae-oncology) within and outside Singapore.
csiadj [at] nus.edu.sg