Researchers Identify Looping Silencers as a Promising Target for Cancer Treatment

June 17, 2021

Gene transcription is controlled largely by transcription factors that bind to enhancers, which are regions of the DNA that loop...

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Jun 17, 2021 Celine Tam 0 comments
Prof. Chng Wee Joo Receives Yong Loo Lin School of Medicine Graduate Mentor of the Year (GRAMAY) Award 2021

June 10, 2021

Congratulations to CSI Deputy Director and Senior Principal Investigator, Prof. Chng Wee Joo, on being conferred the Yong Loo Lin...

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Jun 10, 2021 Celine Tam 0 comments
A Novel Discovery Platform to Identify First-in-Class Druggable Targets for Human Diseases

June 10, 2021

Protein-protein interactions (PPIs) represent a vast repertoire of potential targets for new drugs against human diseases. But not all PPIs...

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Jun 10, 2021 Celine Tam 0 comments
Monopar Announces New Drug Candidate, MNPR-202, and Enters into Collaboration Agreement with the National University of Singapore for Preclinical Evaluation in Cancer

June 4, 2021

WILMETTE, Ill., June 03, 2021 (GLOBE NEWSWIRE) -- Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biopharmaceutical company primarily focused on...

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Jun 04, 2021 Celine Tam 0 comments
Extracellular Vesicles, the Cornerstone of Next-Generation Cancer Diagnosis? (Semin Cancer Biol, May 2021)

June 3, 2021

Despite advancements in cancer screening and diagnostics, a significant number of cancers are still diagnosed at a late stage with...

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Jun 03, 2021 Celine Tam 0 comments
Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer (Mol Ther, May 2021)

June 3, 2021

Dysregulated adenosine-to-inosine (A-to-I) RNA editing is implicated in various cancers. However, no available RNA editing inhibitors have so far been...

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Jun 03, 2021 Celine Tam 0 comments
Topography of Transcriptionally Active Chromatin in Glioblastoma (Sci Adv, Apr 2021)

June 3, 2021

Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylation, and genomic...

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Jun 03, 2021 Celine Tam 0 comments
Reversing Cancer-Causing Faults in the Breast Cancer Gene BRCA2.

May 20, 2021

Inherited faults (‘mutations’) in the breast cancer gene, BRCA2, can lead to cancers of the breast, ovary or other organs....

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May 20, 2021 Celine Tam 0 comments
Congratulations to Dr. Polly Chen on her promotion to Associate Professor!

May 12, 2021

CSI Singapore is proud to announce the promotion of Dr. Polly Chen to Associate Professor! Dr. Chen joined CSI Singapore...

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May 12, 2021 Celine Tam 0 comments
Prolonged Maintenance of Hematopoietic Stem Cells that Escape From Thrombopoietin Deprivation. (Blood, Mar 2021)

April 27, 2021

Hematopoietic stem cells (HSC) rarely divide, rest in quiescence and proliferate only upon stress hematopoiesis. The cytokine thrombopoietin (Thpo) has...

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Apr 27, 2021 Celine Tam 0 comments
Quantitative Imaging of RAD51 Expression as a Marker of Platinum Resistance in Ovarian Cancer. (EMBO Mol Med, Mar 2021)

April 27, 2021

Early relapse after platinum chemotherapy in epithelial ovarian cancer (EOC) portends poor survival. A-priori identification of platinum resistance is therefore...

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Apr 27, 2021 Celine Tam 0 comments
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. (Commun Biol, Apr 2021)

April 27, 2021

Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted...

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Apr 27, 2021 Celine Tam 0 comments
USD 45M Series B Funding for UK-Based Biopharmaceutical Company’s Drug Discovery Programmes

April 19, 2021

The pathways that control the behaviour of cells are complex, non-linear and highly redundant. As such, identifying the right molecular...

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Apr 19, 2021 Celine Tam 0 comments
Novel First-in-Class Drug Discovery Approach is Breaking New Ground in Anti-Cancer Therapeutics

April 19, 2021

ATP-hydrolyzing enzymes like protein kinases are major drug targets for oncology. Drugs that inhibit these enzymes typically engage their ATP-binding...

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Apr 19, 2021 Celine Tam 0 comments
Cancer drug may be able to treat inflammation caused by COVID-19 virus, Singapore-US study shows

April 13, 2021

CSI Principal Investigator, Dr. Anand Jeyasekharan, was recently involved in a pioneering study performed by the Icahn School of Medicine...

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Apr 13, 2021 Celine Tam 0 comments
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