Dec 28, 2021 Celine Tam 0 comments
Dec 24, 2021 Celine Tam 0 comments
Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma (Cancer Res, Dec 2021)

December 24, 2021

Multiple myeloma (MM) is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive...

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Dec 24, 2021 Celine Tam 0 comments
Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer. (Cancer Res, Dec 2021)

December 24, 2021

Multiple noncoding natural antisense transcripts (ncNAT) are known to modulate key biological events such as cell growth or differentiation. However,...

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Dec 24, 2021 Celine Tam 0 comments
13th Frontiers in Cancer Science (FCS) Conference Concluded Successfully

November 18, 2021

The 13th Frontiers in Cancer Science (FCS) conference, held over 3 days from 1 – 3 November 2021, concluded successfully...

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Nov 18, 2021 Celine Tam 0 comments
Pseudogene-Mediated DNA Demethylation Leads to Oncogene Activation. (Sci Adv, Oct 2021)

November 3, 2021

Pseudogenes, noncoding homologs of protein-coding genes, once considered nonfunctional evolutionary relics, have recently been linked to patient prognoses and cancer...

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Nov 03, 2021 Celine Tam 0 comments
Enhanced Penetrative siRNA Delivery by a Nanodiamond Drug Delivery Platform Against Hepatocellular Carcinoma 3D Models. (Nanoscale, Oct 2021)

November 3, 2021

Small interfering RNA (siRNA) can cause specific gene silencing and is considered promising for treating a variety of cancers, including...

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Nov 03, 2021 Celine Tam 0 comments
Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer. (Genome Med, Oct 2021)

November 3, 2021

Our results indicate that combining histone modification and functional assay data may provide a more accurate metric to assess enhancer...

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Nov 03, 2021 Celine Tam 0 comments
CSI Researchers Unveil Novel Insights into the Induction of Gastric Carcinogenesis

October 28, 2021

Within the stomach corpus (main body), tubular invaginations are divided into regions known as the pit, isthmus, neck and base....

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Oct 28, 2021 Celine Tam 0 comments
Researchers Predict Chromatin Interactions Based on Novel Computational Framework

September 28, 2021

Chromatin interactions play significant roles in regulating gene expression. To date, the understanding of the determinants of chromatin interactions remains...

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Sep 28, 2021 Celine Tam 0 comments
Novel Research Paves Way for Better Optimization of Daratumumab Treatment for NK/T lymphoma Patients

September 9, 2021

Natural Killer T cell lymphoma (NKTL) is a highly aggressive form of cancer more frequently occurring in Asia than other...

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Sep 09, 2021 Celine Tam 0 comments
Sep 07, 2021 Celine Tam 0 comments
Virtual Graduation Celebration for the Graduating Classes of 2020 and 2021

September 3, 2021

Congratulations to the graduates of the PhD Graduate Program in Cancer Biology! On 27th August 2021, CSI Singapore organized a...

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Sep 03, 2021 Celine Tam 0 comments
Determinants of Response to Daratumumab in Epstein-Barr Virus-Positive Natural Killer and T-Cell Lymphoma. (J Immunother Cancer, Jul 2021)

August 31, 2021

This study characterizes CD38 as an effective target for a subset of NKTL patients and the utilization of the CD38:CIP...

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Aug 31, 2021 Celine Tam 0 comments
Chromatin Interaction Neural Network (ChINN): A Machine Learning-Based Method for Predicting Chromatin Interactions from DNA Sequences. (Genome Biol, Aug 2021)

August 31, 2021

Chromatin interactions play important roles in regulating gene expression. However, the availability of genome-wide chromatin interaction data is limited. We...

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Aug 31, 2021 Celine Tam 0 comments
Repurposing RNA Sequencing for Discovery of RNA Modifications in Clinical Cohorts. (Sci Adv, Aug 2021)

August 31, 2021

The study of RNA modifications in large clinical cohorts can reveal relationships between the epitranscriptome and human diseases, although this...

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Aug 31, 2021 Celine Tam 0 comments
CSI Director Shares His Thoughts on Building a Great and Inclusive Workplace

August 23, 2021

CSI Singapore Director, Prof. Ashok Venkitaraman, recently shared his experiences and aspirations for inclusive and equitable policies and practices in...

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Aug 23, 2021 Celine Tam 0 comments
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