CSI Principal Investigator and Senior Research Scientist Receive Awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition

May 5, 2022

Congratulations to A/Prof. Edward Kai-Hua Chow and Dr. Bee Hui Liu, who have recently won awards at the Asian Fund...

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May 05, 2022 CK Ong 0 comments
Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Post-Menopausal Women with Hormone Receptor Positive Breast Cancer (Clin Cancer Res, Apr 22)

May 5, 2022

RET is an estrogen response gene with preclinical studies demonstrating cross talk between RET and estrogen receptor (ER) pathways. We...

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May 05, 2022 CK Ong 0 comments
Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22)

May 5, 2022

Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established...

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May 05, 2022 CK Ong 0 comments
Multilayered Control of Splicing Regulatory Networks by DAP3 Leads to Widespread Alternative Splicing Changes in Cancer. (Nat Commun, Apr 22)

May 5, 2022

The dynamic regulation of alternative splicing requires coordinated participation of multiple RNA binding proteins (RBPs). Aberrant splicing caused by dysregulation...

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May 05, 2022 CK Ong 0 comments
CSI Singapore Researchers Uncover Role of ADARs and its Implications in Cancer Development

May 4, 2022

In a novel step forward, A/Prof. Polly Chen and her team embarked on a study to better understand the role...

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May 04, 2022 CK Ong 0 comments
PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22)

April 6, 2022

Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer...

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Apr 06, 2022 CK Ong 0 comments
Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22)

April 6, 2022

Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug development...

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Apr 06, 2022 CK Ong 0 comments
ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022)

April 6, 2022

Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly facilitated by base-pairing of reverse complementary matches (RCMs) in...

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Apr 06, 2022 CK Ong 0 comments
CSI Singapore Researchers Discover Achilles Heel of High-Risk Multiple Myeloma (MM) Patients

April 6, 2022

Chromosomal abnormalities are found in most multiple myeloma (MM) patients. While myeloma patients have generally benefited from the advancement of...

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Apr 06, 2022 CK Ong 2 comments
Mar 10, 2022 CK Ong 0 comments
MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022)

March 7, 2022

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an...

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Mar 07, 2022 CK Ong 0 comments
p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain). (Oncogene, Feb 2022)

March 7, 2022

17p13(del) and 1q21(gain) are critical and independent high-risk cytogenetic markers, however, the biological significance underlying the poor outcome in MM...

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Mar 07, 2022 CK Ong 0 comments
Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022)

March 7, 2022

In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins...

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Mar 07, 2022 CK Ong 0 comments
Uncover the Mysterious, Culpable “Super-Enhancers” in Aggressive Blood Cancer

February 9, 2022

Multiple myeloma (MM) is the second most common blood cancer and remains an incurable disease. In a novel step forward,...

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Feb 09, 2022 CK Ong 0 comments
Feb 07, 2022 CK Ong 0 comments
ChIP-AP: An Integrated Analysis Pipeline for Unbiased ChIP-seq Analysis. (Brief Bioinform, Jan 2022)

February 3, 2022

Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is a technique used to identify protein-DNA interaction sites through antibody pull-down, sequencing and...

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Feb 03, 2022 CK Ong 0 comments
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach. (Cell Mol Gastroenterol Hepatol, Jan 2022)

February 3, 2022

RUNX3R122C missense mutation is associated with the continuous cycling of isthmus stem/progenitor cells, maturation arrest and development of a precancerous state....

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Feb 03, 2022 CK Ong 0 comments
MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021)

February 3, 2022

In this study, we demonstrate that the MYC 3'UTR is shortened in colorectal cancer (CRC). Using unbiased computational and experimental...

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Feb 03, 2022 CK Ong 0 comments
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