Bioinformatics Workshop 2019 – Cancer Science Institute of Singapore (CSI)

Bioinformatics Workshop 2019

Manipulation of public massive ChIPseq and methylome datasets using R

Transcription factors (TFs) are sequence-specific binding proteins controlling the spatiotemporal expression of genes. Since the genomic occupancy of TF is highly dynamic, it is crucial to study TF binding sites (TFBS) in a cell-specific and in vivo context.

This workshop will focus on the manipulation of public cistrome and methylome datasets recorded in MethMotif and TFregulomeR databases, using R packages. These processes greatly facilitate the manipulation and analysis of TFBS and methylome meta-data, in particular for the characterisation of TF binding partners and cell-specific TFBS, along with the study of TF functions depending on their association with other TFs and/or on DNA methylation levels.

Prerequisite:

– Basic knowledge of R language.

– Attendees must bring their own computer with R or RStudio installed.

Speakers

Dennis Thieffry, Ph.D

Professor and Group Leader
Department of Biology
Ecole Normale Supérieure de Paris (ENS), France

Visiting Research Professor
Cancer Science Institute of Singapore, NUS

Touati_BENOUKRAF-2
Touati Benoukraf, Ph.D

Canada Research Chair (Tier II) in Bioinformatics for Personalised Medicine
Assistant Professor, Faculty of Medicine, Discipline of Genetics
Memorial University of Newfoundland, Canada

Visiting Assistant Professor
Cancer Science Institute of Singapore, NUS

Assistants

TB - Roberto
Roberto Tirado-Magallanes
TB - Xiao Xuan
Xiaoxuan Lin

Venue

NUS, Centre for Translational Medicine (MD6),
#04-01 SMART Classroom
14 Medical Drive, S117599

Date and Time

11 November 2019, Monday

9.30 am – 5.00 pm

Program

09:00 – 09:30 Arrival and Registration
09:30 – 12:30 1.     Introduction on bioinformatics analysis of transcriptional regulatory motifs

2.     Two novel tools for the analysis of context-sensitive transcription factor binding: MethMotif and TFregulomeR

3.     Useful commands in R

12:30 – 14:00 Lunch Refreshments
14:00 – 17:00 Computer tutorial on MethMotifs and TFregulomeR

Notes:

Please arrive 10 minutes early for registration

Attendees are required to bring own laptops.

Light Refreshments provided

Registration

Registration fee chargeable Fee
Workshop $50

Price is subjected to 7% GST

Registration for this workshop is limited to 20 attendees.

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