Bioinformatics Workshop 2019 – Cancer Science Institute of Singapore (CSI)

Bioinformatics Workshop 2019

Manipulation of public massive ChIPseq and methylome datasets using R

Transcription factors (TFs) are sequence-specific binding proteins controlling the spatiotemporal expression of genes. Since the genomic occupancy of TF is highly dynamic, it is crucial to study TF binding sites (TFBS) in a cell-specific and in vivo context.

This workshop will focus on the manipulation of public cistrome and methylome datasets recorded in MethMotif and TFregulomeR databases, using R packages. These processes greatly facilitate the manipulation and analysis of TFBS and methylome meta-data, in particular for the characterisation of TF binding partners and cell-specific TFBS, along with the study of TF functions depending on their association with other TFs and/or on DNA methylation levels.


– Basic knowledge of R language.

– Attendees must bring their own computer with R or RStudio installed.


Dennis Thieffry, Ph.D

Professor and Group Leader
Department of Biology
Ecole Normale Supérieure de Paris (ENS), France

Visiting Research Professor
Cancer Science Institute of Singapore, NUS

Touati Benoukraf, Ph.D

Canada Research Chair (Tier II) in Bioinformatics for Personalised Medicine
Assistant Professor, Faculty of Medicine, Discipline of Genetics
Memorial University of Newfoundland, Canada

Visiting Assistant Professor
Cancer Science Institute of Singapore, NUS


TB - Roberto
Roberto Tirado-Magallanes
TB - Xiao Xuan
Xiaoxuan Lin


NUS, Centre for Translational Medicine (MD6),
#04-01 SMART Classroom
14 Medical Drive, S117599

Date and Time

11 November 2019, Monday

9.30 am – 5.00 pm


09:00 – 09:30 Arrival and Registration
09:30 – 12:30 1.     Introduction on bioinformatics analysis of transcriptional regulatory motifs

2.     Two novel tools for the analysis of context-sensitive transcription factor binding: MethMotif and TFregulomeR

3.     Useful commands in R

12:30 – 14:00 Lunch Refreshments
14:00 – 17:00 Computer tutorial on MethMotifs and TFregulomeR


Please arrive 10 minutes early for registration

Attendees are required to bring own laptops.

Light Refreshments provided


Registration fee chargeable Fee
Workshop $50

Price is subjected to 7% GST

Registration for this workshop is limited to 20 attendees.

Online Registration and Payment Instructions:

1. After completing the registration form, you will be prompted to make payment online via a credit card.

2. In the event your payment fails, please kindly arrange for payment via another credit card.

3, After completing the online payment, a payment receipt will be displayed, please save or print a copy of the original payment receipt.

4. Please leave your browser open after making payment until you get to see the payment receipt. Do not use BACK or RELOAD/REFRESH browser functions or CLOSE browser while using the service until the payment receipt or the Error page is displayed.

5. Browsers supported are Mozilla Firefox, Safari and Chrome. Please disable pop-up blocker.

6. For payment method Credit/Debit Card (VISA/Mastercard), a one-time password (OTP) would be required to authenticate the cardholder’s identity. You will be redirected to a page to enter the OTP (which is issued by the card issuing bank to the cardholder by SMS, text message or token) before payment can be completed. For cards issued outside Singapore, authentication or the issue of OTP may vary.

7. Please click here to view the payment system scheduled maintenance schedule for the month.

Registration is CLOSED.