Apply here.

Apply here.

Apply here.

Apply here.

The laboratory executive will provide support to the Principal Investigator and his team in terms of research, laboratory and administrative needs.

Duties and Responsibilities:

a) Research:

• To carry out assigned experiments
• To organise, preserve and present the results of the experiments in a logical manner
• To properly and systematically record all experiments that have been assigned and their results
• To analyse and plan further experiments under guidance
• To assist in supervising, training and guiding attachment/undergraduate students where required

b) Laboratory:

• To plan and ensure the needs and requirements of the team in terms of consumables
• To ensure that the lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for experiments
• Responsible for the cleanliness and maintenance of equipment through regular checks
• Required to assemble reagents, chemicals and media that are needed for experiments
• To ensure that standard operating procedures and safety regulations are followed
• Responsible for the general cleanliness of the lab

c) Administrative duties:

• To plan and ensure that the overall lab administrative needs of the team are met
• To assist the Principal Investigator in tracking his/her grants and other sources of funding
• Responsible for purchasing necessary equipment, chemicals, reagents as required by the lab or project
• Maintain a systematic and proper record of all purchases
• Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies

d) Any other duties as required

Qualifications:

• University degree
• Ability to speak and write well in English

Knowledge of:

• Basic principles and practices in the fields of biology, physiology and/or chemistry.
• Quality assurance procedures applicable to a laboratory.
• Principles, techniques and terminology used in the examination of clinical and animal samples.
• Principles, techniques and terminology used in cancer biology.
• Laboratory scientific resource material; laboratory equipment and its care.
• Methods of scientific research and relevant scientific theories.
• Government guidelines and regulations pertinent to laboratory safety and security.
• Packaging and shipping of diagnostic, infectious and hazardous materials.
• Appropriate computer operations, software and peripherals.
• General rules for safe exposure and handling of chemical and biological hazards
• IRB, OSHE & IACUC regulations

Ability to:

• Perform laboratory tests
• Work cooperatively and effectively with others

Please apply here.

The Cancer Science Institute (CSI) of Singapore — a part of the National University of Singapore —  is seeking a manager for its Genomics and Data Analytics Core (GeDaC). He/she will be responsible for designing and implementing a technical roadmap for genome science at CSI. This is an opportunity to support CSI’s vision to become a world leader in cancer genome science. With a team of laboratory assistants, bioinformaticians, and software engineers, the GeDaC is expected to provide:

1) Bespoke bioinformatics pipelines and technical assistance to individual projects
2) A scalable infrastructure for DNA/RNA-seq processing and analytics
3) Assistance with data management and storage
4) Sequencing library preparation techniques and validation services

The Core Manager will oversee both scientific and administrative operations to ensure the aforementioned deliverables are met. All solutions must be agile and evolve over time to adapt to new standards. Finally, this individual will liaise with key personnel to ensure interoperability of CSI platforms with other key stakeholders in Singapore.

The Core Manager will report to the CSI Director as well as a Technical Advisory Board. Successful candidates will have a deep background in either genome analysis or genomics project management. He/She must possess long-term vision while maintaining a keen sense of near-term prioritization. As GeDaC solutions will be built upon Amazon Web Services (AWS), familiarity with cloud-based architecture is a must. This individual must possess the technical savvy to explain, troubleshoot, and solve issues with scientists, software developers and bioinformaticians. The ideal candidate would be a very effective communicator with people of diverse backgrounds.

BASIC QUALIFICATIONS

• Ph.D in bioinformatics, genomics, computational biology, computer science, or related field
• 3+ years post-PhD experience
• Excellent academic track record as evidenced by publications
• Expertise in high-throughput sequencing analysis
• Software development experience
• Familiarity with cloud architecture
• Previous team management experience
• Excellent communication skills in both written and spoken English

ADDITIONAL QUALIFICATIONS WHICH WILL BE AN ADVANTAGE:

• Familiarity with computer hardware
• Knowledge of sequencing library preparation techniques
• Experience migrating data and workloads to the cloud
• Familiarity with the AWS software stack
• Familiarity with system management, quality and security practices (e.g. ISO certification)

Please apply here.

This position exists to manage and operate the next-generation sequencing core facility (i.e., Genomics Bench), to oversight, and provide day to day administrative support of the GeDaC on matters pertaining to organisational infrastructure, liaison between the GeDaC divisions/sections, business/budget, and reports/updates.

Duties & Responsibilities

a) Research:

• To carry out assigned experiments including culturing cell lines, nucleic acids extraction, PCR, and other related protocols
• Prepare sequencing libraries, perform quality assessment and sequencing runs
• To organise, preserve and present the results of the experiments in a logical manner
• To properly and systematically record all experiments that have been assigned and their results, ensuring proper documentation of experiments and sequencing runs
• To analyse and plan further experiments under guidance including troubleshooting of experiments and sequencing runs
• To assist in supervising, training and guiding attachment/undergraduate students where required

b) Laboratory:

• To ensure that lab consumables required for experiments are adequately stocked
• Responsible for the cleanliness and maintenance of equipment through regular checks
• Required to assemble reagents, chemicals and media that are needed for experiments
• To ensure that standard operating procedures and safety regulations are followed
• Assist to ensure the general cleanliness of the lab

c) Administrative duties:
Finance, Budget & Pricing Support

• Assemble annual pricing for services with projected income targets
• Draw up annual budget of the Facility for co-Heads approval
• Maintain detailed and accurate records for audits as needed to ensure accuracy and maintain compliance
• Plan and ensure the needs and requirements of the team including assistance in billings, procurement, and maintenance of consumables inventory
• Maintain a systematic and proper record of all purchases
• Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies

HR

• Assist in recruitment of new staff from drafting job descriptions/recruitment requests to shortlisting and interview process
• Onboarding of new staff including ensuring assignment of space, equipment, etc as required
• Induction/orientation of new staff into the team and training where necessary, is provided.
• Assist in annual appraisal exercise where required

Outreach

• Assist co-Heads to plan outreach/training programmes, workshops for the facility, and regularly scheduled journal clubs,
• Effective marketing including facility webpages, roadshows, etc to encourage scientists to use the Facility

Communications & Service

• Assist co-Heads to communicate and liaise with the specialised and trained core facility teams to provide effective customer service and management of projects undertaken
• Partner with Principal Investigators where necessary to assist to establish project needs, measure progress and address issues that arise

Requirements

• Master’s or Ph.D. on molecular biology, genetics, or related fields
• At least 1 year of experience working in molecular biology laboratory
• Hands-on laboratory experience with cell culture, extraction of nucleic acids, PCR, and other related protocols
• Meticulous and organized
• Excellent problem solving and interpersonal skills
• Excellent written and spoken English

Preferences

• Experience with chromatin immunoprecipitation (ChIP), Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq), library preparation
• Knowledge on Next-Generation Sequencing
• Experience with staff supervision

Please apply here.

BACKGROUND

The position of DevOps Software Engineer is immediately available in the Genome and Data Analytics Core (GeDaC) at the Cancer Science Institute of Singapore (CSI) — a part of National University of Singapore. The CSI GeDaC is building a platform to facilitate the automated processing and analysis of large cancer genomics datasets. Successful candidates, in conjunction with bioinformatics experts, will build and optimize various components of this platform. This position provides a unique opportunity to apply DevOps skills to Amazon Web Services (AWS), data-intensive computing, and artificial intelligence to drive novel discoveries in cancer genomics.

RESPONSIBILITIES

Participate in the continued development of:

• Deploy and optimize of scalable genome processing workflows on AWS
• Facilitate cost-effective analytics via AWS microservices and serverless architecture (Lambda, Fargate, Aurora, etc.)
• Assist with database design, implementation, and management
• Enable unit testing and deployment automation (CI/CD)
• Help manage data ingress and egress to S3/Glacier

REQUIREMENTS

• Bachelors or Masters degree (minimally) in computer science, information systems, bioinformatics, engineering, mathematics, or related fields
• 2+ years of DevOps experience
• Strong Python programming skills and proficiency with Unix-based systems
• Experience with collaborative software development via github/gitlab
• Database management experience (SQL, NoSQL, Elasticsearch, etc.)
• Excellent written and spoken English

PREFERENCES

• Some knowledge of biology and genetics
• Software development experience in industry
• Past projects using CI/CD tools on commercial clouds
• Experience with on-prem to cloud data migrations
• AWS certifications

HOW TO APPLY

Please apply here.

A postdoctoral position is available immediately in Prof. Yoshiaki Ito’s lab. The successful candidate will study one of the following on-going projects.

1. Characterization of two types of stem cells in stomach. It is widely accepted that cancer originates from aberrant regulation of tissue stem cells.  However, studies of tissue stem cells in many organs are still at early stages.  There are two types of stem cells in stomach:  rapidly proliferating stem cells (Isthmus stem cells) and dormant stem cells, a subpopulation of terminally differentiated chief cells at the gland base.  Isthmus stem cells are responsible for generating all cell types in the stomach under the homeostatic conditions.  We recently identified cytoskeletal scaffold protein, IQGAP3, as a highly specific isthmus stem cell factor during homeostasis (GUT, 2020).  We further found that upon tissue damage, IQGAP3 was robustly induced in dormant stem cells, which acquired proliferating capacity to engage in tissue repair.  The objective is detailed molecular characterization of these two types of stem cells.
2. IQGAP3 is also widely expressed in rapidly proliferating areas of gastric cancer. We call IQGAP3 the “common denominator of homeostasis, tissue repair and cancer”.  Tumors have been described as “wounds that do not heal (Dvorak, 1986)”. We will investigate the possibility that elevated IQGAP3 expression during chronic tissue damage induces cell plasticity and redirects cell fate to drive malignant transformation.
3. We have identified transcription factors responsible for the exclusive expression of IQGAP3 in stem cells. We have also found the proteins that interact with and stabilize the IQGAP3 mRNA in stem cells.  We will study the role of IQGAP3 in the formation of stomach epithelial stem cells during development. Conversely, we found that depletion of these transcription factors in undifferentiated cancer cells induced differentiation as well as reduced cancer cell properties.  Understanding how these factors regulate IQGAP3 will lead to novel insights on induction of terminal differentiation as cancer therapy for aggressive tumor types.
4. The fact that IQGAP3 is expressed not only in gastric but virtually all other types of cancer cells indicates a fundamental role for IQGAP3 in cancer growth. Developing drugs to inhibit IQGAP3 activity will be important.

We seek a highly motivated and innovative postdoctoral fellow with the ability to work independently and as part of a team. Candidates should have PhD and/or MD degree with a strong background in molecular biology, biochemistry and cell biology. Prior experience with using mouse models to study cancer and 1-2 years of postdoctoral experience in these areas are preferred.

Applications should include cover letter, curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information of 2 referees (email and telephone numbers). Please also include a summary of your research experience.

Kindly send your application to:
April Chan (aprilchy@nus.edu.sg)
Cancer Science Institute, National University of Singapore

Please apply here.

We are seeking a highly motivated candidate as a Laboratory Executive who can provide support to the Fluorescence Activated Cell Sorting (FACS) Facility in terms of facility/laboratory, research and administrative needs. A candidate should be committed, self-motivated, conscientious, and able to work independently.

Duties & Responsibilities

a) Facility and laboratory

• Be responsible for the operation and maintenance of flow cytometry machines
• To provide flow sorting service for users
• To ensure that the facility/lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for smooth operation of the facility
• To ensure that standard operating procedures and safety regulations are followed

b) Research

• Responsible for maintenance/management of the laboratory mouse colony
• To properly and systematically plan, perform and record mouse breeding schemes
• To assist in carrying out animal experiments and downstream analysis with supervisors

c) Administrative duties

• To perform procurement and payment of facility/laboratory items in a timely manner

Requirements:

• BSc degree in life sciences or its equivalent. Fresh graduates are welcome to apply
• Prior experience in flow operation or animal (mouse) handling is an added advantage
• Background and working knowledge of basic molecular and cellular biology
• Excellent communication skills and good team spirit
• Fluent in spoken and written English

Applications should include in a single PDF a cover letter, curriculum vitae, certificates of qualifications and the names and contact information of at least 2 professional references.

Please apply here.

We are looking for a highly motivated candidate to join us as a Laboratory Executive in Prof. H. Phillip Koeffler’s lab in Cancer Science Institute of Singapore (CSI), in collaboration with Dr. Ding Lingwen from Department of Pathology.

The candidate will assist the team in research activities, including performing experiments (e.g., sample processing, real time PCR and western blot); and providing budget management and support for existing and ongoing projects.

The candidate will learn and conduct experiments related to breast cancer research and cancer immunotherapy, and will be exposed to latest cutting-edge technologies such as CRISPR, NGS sequencing etc.

Recent Publications of Prof Koeffler’s lab can be found in Google Scholar.

Requirements:

• Highly motivated, hardworking and have a passion for research.
• Degree in life sciences or equivalent.
• Experience in molecular biology would be an added advantage.

Applications should include in a PDF with a curriculum vitae, certificates of qualifications and the names and contact information of 2-3 professional references.

Please send applications to:

Prof Koeffler: H.Koeffler@cshs.org and Dr Ding Lingwen: patdl@nus.edu.sg

Please apply here.

To provide support to the Principal Investigator and his team in terms of research, laboratory and administrative needs.

Duties & Responsibilities
a) Research:

• To carry out assigned experiments
• To organise, preserve and present the results of the experiments in a logical manner
• To properly and systematically record all experiments that have been assigned and their results
• To analyse and plan further experiments under guidance
• To assist in supervising, training and guiding attachment/undergraduate students where required

b) Laboratory:

• To plan and ensure the needs and requirements of the team in terms of consumables
• To ensure that the lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for experiments
• Responsible for the cleanliness and maintenance of equipment through regular checks
• Required to assemble reagents, chemicals and media that are needed for experiments
• To ensure that standard operating procedures and safety regulations are followed
• Responsible for the general cleanliness of the lab

c) Administrative duties:

• To plan and ensure that the overall lab administrative needs of the team are met
• To assist the Principal Investigator in tracking his/her grants and other sources of funding
• Responsible for purchasing necessary equipment, chemicals, reagents as required by the lab or project
• Maintain a systematic and proper record of all purchases
• Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies

d) Any other duties as required

Requirements:

• Background in genomics, molecular biology and flow cytometry is preferred
• Committed, hardworking and motivated candidates with BSc or diploma are welcome to apply
• Knowledge of:
  • Basic principles and practices in the fields of biology, physiology and/or chemistry
  • Quality assurance procedures applicable to a laboratory
  • Principles, techniques and terminology used in the examination of clinical and animal samples
  • Principles, techniques and terminology used in cancer biology
  • Laboratory scientific resource material; laboratory equipment and its care
  • Methods of scientific research and relevant scientific theories
  • Government guidelines and regulations pertinent to laboratory safety and security
  • Packaging and shipping of diagnostic, infectious and hazardous materials
  • Appropriate computer operations, software and peripherals
  • General rules for safe exposure and handling of chemical and biological hazards
  • IRB, OSHE & IACUC regulations
• Ability to:
• • Perform laboratory tests

Applications should include full curriculum vitae and indicate the names of at least 2 referees.

Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Please note that only shortlisted candidates will be contacted.

Requirements:

• University degree (biology, biomedical science, biotechnology or related area).
• Ability to speak and write well in English.
• Prior experience working with animal model (mouse and/or zebrafish) is required.
• Knowledge of: 1) basic principles and practices in the fields of biology, 2) principles, techniques and terminology used in biology, 3) principles, techniques and terminology used in animal studies.
• Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint.

Job Scope:
a) Laboratory tasks: 50%

• To maintain animal (mouse and zebrafish) colonies, including breeding and genotyping procedures.
• To create transgenic and knockout animal models (mouse and zebrafish).
• To perform xenograft studies using animal models (mouse and zebrafish).
• To monitor health status and phenotypes (e,g, tumor development, hematopoietic phenotypes).
• To isolate tissues (e.g., bone marrow, thymus, spleen) from the animals.
• To harvest cells, protein, RNA or DNA from animal tissues, cell lines or bacteria.
• To analyze the cells by flowcytometry.
• To perform experiments including PCR, immunoprecipitation and Western blot.

b) Administrative tasks: 30%

• To maintain a systematic and proper record of animals, including annual reports.
• To liaise with the core facilities, committees and the administrative office to assist research.
• To be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project.
• To liaise with the vendors to ensure proper purchase requisitions, goods delivery and prompt payment of supplies.

c) Laboratory safety: 20%

• To serve as a safety lead in the laboratory.
• To create and review standard operating procedures and risk assessments.
• Responsible for the general cleanliness of the lab and core facility.
• To assemble reagents, chemicals and media that are needed for experiments.

Applications should include full curriculum vitae and indicate the names of at least 2 referees.

Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Please note that only shortlisted candidates will be contacted.

The laboratory executive will provide support to the Principal Investigator and her team in terms of research, laboratory and administrative needs.

Duties and Responsibilities:

a) Research:

• To carry out assigned experiments
• To conduct troubleshooting and refining of experimental procedures
• To organise, preserve and present the results of the experiments in a logical manner
• To properly and systematically record all experiments that have been assigned and their results
• To analyse and plan further experiments under guidance
• To keep abreast with the current research scene and to propose relevant techniques and latest technologies to answer hypothetical research questions
• To assist in supervising, training and guiding attachment/undergraduate students where required

b) Laboratory:

• To plan and ensure the needs and requirements of the team in terms of consumables
• To ensure that the lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for experiments
• Responsible for the cleanliness and maintenance of equipment through regular checks
• Required to assemble reagents, chemicals and media that are needed for experiments
• To ensure that standard operating procedures and safety regulations are followed
• Responsible for the general cleanliness of the lab

c) Administrative duties:

• To plan and ensure that the overall research/lab administrative needs of the team are met, such as producing reports and preparing presentation slides
• Responsible for purchasing necessary equipment, chemicals, reagents as required by the lab or project
• Maintain a systematic and proper record of all purchases
• Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies

d) Any other duties as required

Requirements:

• Background in genomics, cell and molecular biology, NGS and flow cytometry.
• Committed, dedicated, diligent and motivated candidates with BSc or diploma are welcome to apply.
• Willing to clock in extra hours (including coming back to the lab during the weekends) when there is an urgency to fulfill research deadlines
• Willing to perform mouse work
• A team player

Knowledge of:

• Basic principles and practices in the fields of biology, physiology and/or chemistry
• Principles, techniques and terminologies used in cancer biology
• Scientific and cancer research methodologies
• Principles, techniques and terminology used in the examination of clinical and animal samples
• Scientific data analysis softwares such as FlowJo, CompuSyn and PRISM
• Quality assurance procedures applicable to a laboratory
• Government guidelines and regulations pertinent to laboratory safety and security
• Packaging and shipping of diagnostic, infectious and hazardous materials
• General rules for safe exposure and handling of chemical and biological hazards
• IRB, OSHE & IACUC regulations

Applications should include full curriculum vitae and the names, addresses and contact numbers of 3 professional references. Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

To provide support to the Principal Investigator and his team in terms of research, laboratory and administrative needs.

Responsibilities

a) Research:

• to carry out assigned experiments
• to organise, preserve and present the results of the experiments in a logical manner
• to properly and systematically record all experiments that have been assigned and their results
• to analyse and plan further experiments under guidance
• to assist in supervising, training and guiding attachment/undergraduate students where required

b) Laboratory:

• to plan and ensure the needs and requirements of the team in terms of consumables
• to ensure that the lab is adequately stocked with clean glassware, minor equipment chemicals, etc. required for experiments
• responsible for the cleanliness and maintenance of equipment through regular checks
• required to assemble reagents, chemicals and media that are needed for experiments
• to ensure that standard operating procedures and safety regulations are followed
• responsible for the general cleanliness of the lab

c) Administrative duties:

• to plan and ensure that the overall lab administrative needs of the team are met
• to assist the Principal Investigator in tracking his/her grants and other sources of funding
• responsible for purchasing necessary equipment, chemicals, reagents as required by the lab or project
• maintain a systematic and proper record of all purchases
• liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies

d) Any other duties as required

Requirements

• Degree in Life Sciences or its equivalent. Fresh graduates are welcome to apply.
• Knowledge of mouse work is an added advantage
• Ability to speak and write well in English

Knowledge of

• Basic principles and practices in the fields of biology, physiology and/or chemistry.
• Quality assurance procedures applicable to a laboratory.
• Principles, techniques and terminology used in the examination of clinical and animal samples.
• Principles, techniques and terminology used in cancer biology.
• Laboratory scientific resource material; laboratory equipment and its care.
• Methods of scientific research and relevant scientific theories.
• Government guidelines and regulations pertinent to laboratory safety and security.
• Packaging and shipping of diagnostic, infectious and hazardous materials.
• Appropriate computer operations, software and peripherals.
• General rules for safe exposure and handling of chemical and biological hazards
• IRB, OSHE & IACUC regulations
• Ability to:
  • Perform laboratory tests
  • Work cooperatively and effectively with others

Applications should include full curriculum vitae and the names, addresses and contact numbers of 3 professional references. Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg