Biomedical research is exploding with data. The Chew Lab (https://www.csi.nus.edu.sg/web/chew-guo-liang/) at the Cancer Science Institute of Singapore (CSI) at the National University of Singapore seeks to make sense out of these data: to understand fundamental molecular mechanisms underlying human disease so that we may design better treatments.

For examples of the work we do, see:

• Chew, Campbell et al. DUX4 suppresses MHC Class I to promote cancer immune evasion and resistance to checkpoint blockade. Dev Cell 2019. https://doi.org/10.1016/j.devcel.2019.06.011
• Inoue, Chew et al. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature 2019. https://doi.org/10.1038/s41586-019-1646-9

Our interests will evolve over time. We are currently focused in the interactions between cancer and the immune system, and how these interactions may be mediated by the aberrant expression of genes with endogenous roles in human development.

We are looking for a full-time bioinformatics data scientist to join us.

In this position, you will:

• Integrate high-throughput data (e.g. proteomics, RNA-seq) from hundreds to thousands of patients
• Derive experimentally-testable hypotheses, molecular insight from integrated analyses of high-throughput patient and experimental data
• Communicate findings to clinical and experimental collaborators
• Contribute to scientific discussions within the lab, at CSI and in the greater community
• With guidance/coaching, develop yourself personally and professionally for a long term career in biomedical research

You would need:

• A PhD in a relevant field (e.g. cancer biology, bioinformatics, molecular biology)
• A track record of applying bioinformatics to biomedical research
• Working proficiency in R, Python or similar programming languages (we primarily use R)
• Working knowledge of statistics as applied in a biomedical research setting

It would be great if you had:

• Prior experience in wet-lab molecular biology, especially with generating NGS data
• Familiarity with tidy data, Bioconductor, version control, workflow management software, working on servers/clusters/cloud
• A broad interest in many aspects of biology

If you are interested, please contact Dr. Chew at via email at guoliang@nus.edu.sg (with an email subject containing the words “CSI bioinformatics postdoctoral position”), and include a detailed CV and contact information of at least two referees (including that of your current / most recent position). Please also provide a description of your research interests, including how your own experience would augment/complement our ongoing work. We will only contact candidates who are shortlisted.

A full time Research Assistant position will be available after March 2020.

Requirements:

• University degree (biology, biomedical science, biotechnology or related area).
• Ability to speak and write well in English.
• Prior experience working with mouse or/and zebrafish model.
• Knowledge of: 1) basic principles and practices in the fields of biology, 2) principles, techniques and terminology used in biology, 3) principles, techniques and terminology used in animal studies.
• Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint.

Job scope:
a) Animal management and laboratory tasks: 50%

• to maintain animal colonies including breeding and genotyping.
• to create transgenic and knockout animal models, and perform xenograft studies.
• to isolate tissues from the animal and analyze by flowcytometry.
• to harvest cells, protein, RNA or DNA from animal tissues, cell lines or bacteria.
• to perform experiments including PCR, immunoprecipitation and Western blot.

b) Administrative tasks: 30%

• to maintain a systematic and proper record of animals, including annual reports.
• to liaise with the core facilities, committees and the administrative office to assist research.
• to be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project.
• to liaise with the vendors to ensure proper purchase requisitions, goods delivery and prompt payment of supplies.

c) Laboratory safety: 20%

• to serve as a safety lead in the laboratory.
• to create and review standard operating procedures and risk assessments.
• responsible for the general cleanliness of the lab and core facility
• to assemble reagents, chemicals and media that are needed for experiments.

Applications should include full curriculum vitae and 2-3 reference letters. Please note that only shortlisted candidates will be contacted.

Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Are you a biomedical researcher motivated to pursue an outstanding career in cancer research?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Senior Research Scientist to join the team of our new Director-designate, Prof. Ashok Venkitaraman, who will be joining us from the University of Cambridge (see http://news.nus.edu.sg/press-releases/cancer-science-institute-director). This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).

Essential qualifications:

• PhD in a relevant field and three years’ relevant post-doctoral experience in a high-quality research environment
• Strong track record of research achievement evidenced by high-quality publications in a relevant field
• High-level experience in a wide range of relevant research methods including molecular and cell biology, somatic cell genetics, protein & nucleic acid biochemistry, advanced fluorescence microscopy and flow cytometry
• Proven skills in working independently and creatively to solve experimental problems
• Effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports
• Demonstrated skills in hands-on training of students or staff

Preference will be given to candidates with:

• Previous experience in research on genome stability mechanisms in carcinogenesis
• Knowledge of DNA repair, replication and mitosis in oncogenesis and tumour suppression
• Previous experience with genetically engineered murine models

The successful candidate will take a leading role in pioneering research on the role of genome instability in human carcinogenesis by:

• Undertaking research aimed at defining the role of genome instability in human cancer, with a focus on carcinogenesis associated with mutations affecting the BRCA2 tumour suppressor
• Planning their own work and objectives on a 12-month basis and managing their experimental work within the project under the overall supervision of the PI
• Working with relative independence to identify, develop, modify and apply techniques across a wide range of disciplines to achieve the goals of the project, using creativity and initiative to develop novel approaches and methods where required.
• Presenting scientific work at seminars within the laboratory and at external meetings
• Contributing to lab-wide discussions on developments within the field
• Drafting scientific papers, and contributing to the overall preparation of research for publication
• Contributing to the CSI’s mission in the public engagement of science, and the translation of research findings into improvements in health care
• Assisting in the training of PhD students and staff
• Contributing to the smooth running of the research group, including the effective use of resources, training of others and taking responsibility for use of communal facilities

More information on careers in NUS can be found at http://www.nus.edu.sg/careers/

Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Applications will be considered until 15 February 2020 or until the position is filled.
We will only contact candidates who are shortlisted.

Are you a biomedical researcher motivated to pursue an outstanding career in cancer research?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Research Fellow to join the team of our new Director-designate, Prof. Ashok Venkitaraman, who will be joining us from the University of Cambridge (see http://news.nus.edu.sg/press-releases/cancer-science-institute-director). This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).

Essential qualifications:

• PhD in a relevant field undertaken in a high-quality research environment; previous postdoctoral experience is not necessary
• Strong track record of research achievement in a relevant field
• Hands-on experience in relevant research methods, with demonstrated skills in one or more fields including molecular and cell biology, somatic cell genetics, protein & nucleic acid biochemistry, advanced fluorescence microscopy or flow cytometry
• Effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports

Preference will be given to candidates with:

• Previous experience in research on genome stability mechanisms in carcinogenesis
• Knowledge of DNA repair, replication and mitosis in oncogenesis and tumour suppression
• Previous experience with genetically engineered murine models.

The successful candidate will play a key role in pioneering research on the role of genome instability in human carcinogenesis by:

• Undertaking research aimed at defining the role of genome instability in human cancer, with a focus on carcinogenesis associated with mutations affecting the BRCA2 tumour suppressor
• Planning their own work and objectives on a 3-month basis and managing their experimental work within the project under the overall supervision of the PI
• Working with relative independence to identify, develop, modify and apply techniques across a wide range of disciplines to achieve the goals of the project, using creativity and initiative to develop novel approaches and methods where required.
• Presenting scientific work at seminars within the laboratory and at external meetings
• Contributing to lab-wide discussions on developments within the field
• Drafting scientific papers, and contributing to the overall preparation of research for publication
• Contributing to the CSI’s mission in the public engagement of science, and the translation of research findings into improvements in health care

More information on careers in NUS can be found at http://www.nus.edu.sg/careers/

Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Applications will be considered until 15 February 2020 or until the position is filled.
We will only contact candidates who are shortlisted.

A research assistant / associate position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Honours’ / advanced degree holder with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data and write papers.

The Tay lab is in the Cancer Science Institute of Singapore, a state-of-the-art research center with a multifaceted and coordinated approach to cancer research, extending from basic cancer studies all the way to experimental therapeutics. The focus of the institute is on cancers endemic to Asian populations such as gastric, liver, lung, leukemia and breast cancers. The institute houses a full spectrum of research and clinical translational facilities. This major center is led by a team of world-class scientists with significant government funding from Singapore’s National Research Foundation and Ministry of Education.

Qualifications:

• A Bachelor’s degree in a life science-related field
• Experience with in vivo animal models, particularly mice and/or zebrafish
• Expertise in RNA biology (including but not limited to microRNAs) is preferred
• Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
• Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable
• Ability to communicate in written and spoken English

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Related publications:

• Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455(7216),1124-1128.
  • Selected by Faculty of 1000
• Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147, 344–357.
  • Selected by Faculty of 1000
• Tay Y, Rinn J, Pandolfi PP. (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature. 505, 344-352.