Research Positions Available
Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.
Research
Research Assistant – Dr Dennis Kappei
We are seeking a highly motivated candidate as a research assistant in the Quantitative Proteomics Core in collaboration with the Kappei lab at the Cancer Science Institute of Singapore (CSI). Our team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study protein expression, protein interactions as well as post-translational modifications.
Specifically, the successful candidate will support the team in terms of sample processing, maintenance of the mass spectrometer, establishing of novel proteomics approaches with a particular focus on Clinical Proteomics applications. In addition, the work scope will include administrative duties (including ordering and budgeting) and general laboratory organization (including safety standards). We are offering a position in a stimulating, diverse and international research environment as well as the opportunity to gain expertise in a highly demanded technology.
Requirements:
- Degree in life sciences or equivalent; fresh graduates are welcome to apply
- Excellent communication skills and good team spirit
- Fluent in spoken and written English
- Outstanding organizational skills
Practical experience with mass spectrometry work and molecular biology techniques are an added advantage but not a requirement.
Applications should include in a single PDF a 1-page cover letter, curriculum vitae, certificates of qualifications and the names and contact information of at least 2 professional references. Please send applications with the reference “Quantitative Proteomics RA” to:
Dr. Dennis Kappei
Principal Investigator
CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Further information on the Cancer Science Institute of Singapore as well as working at CSI can be found on our website: www.csi.nus.edu.sg/web/careers/
Apply via: https://careers.nus.edu.sg/job-invite/18981/
Research Assistant / Associate – Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on organoid research?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Assistant/ Associate to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
The role will provide expertise in the establishment, genetic manipulation and maintenance of human and murine cell cultures, performance of animal work as well as design/ perform and analyse work within the project parameters.
Duties & Responsibilities
Research:
o design, perform and analyse work with mouse models
o to carry out assigned molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations as tasked
o to organise, preserve and present the results of the experiments in a logical manner
o to properly and systematically record all experiments that have been assigned and their results
Lab Management:
o maintain up to date records of inventories for chemical/ biological reagents
o assist when required with procurement
o ensure tidiness and cleanliness of the lab is maintained
Requirements
- University degree in a relevant field
- Significant amount of experience working with human and/ or murine organoids
- Ability to speak and write clearly in English
- Minimum 2 to 3 years work experience in a molecular biology lab;
- Qualified (RCULA) to work with animal models with practical experience
Knowledge of:
o Basic principles and practices in the fields of biology.
o Principles, techniques and terminology used in cancer biology.
o Methods of scientific research and relevant scientific theories.
o Appropriate computer operations, software and peripherals.
o General rules for safe exposure and handling of chemical and biological hazards
o IRB, HBRA & IACUC regulations
o Principles, techniques and terminology used in organoid model systems and genomic and RNA sequencing as well as common lab molecular and cell biology techniques (desirable)
Ability to:
o Perform laboratory tests in an efficient and timely manner
o Work cooperatively and effectively with others
Apply here.
Research Associate - Prof Daniel Tenen
A research associate position is available immediately in Prof Daniel Tenen’s lab for a highly motivated Master or Ph.D. graduate with background in molecular or cellular biology, and bioinformatics to develop a novel, fully automated analysis pipeline for the newly emerging ChIP sequencing methods: “Cut and Run” and “Cut and Tag” in cancer related study. The successful candidate will help to design pipeline, conduct experiments pipelines, analyse data and write papers.
Qualifications:
- At least a Master in cancer biology or related area
- Expertise in RNA biology preferred
- Strong background and working knowledge of basic molecular, cellular biology science and bioinformatics skills in analysing large sequencing datasets
- Experience with analyses of human clinical samples, RNA sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable
- A proven track record in the form of publications in top international English language journals
- Ability to communicate in written and spoken English
Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.
Apply here.
Research Fellow - Dr Sriram Sridharan
A postdoctoral position is available immediately for an extremely motivated Ph.D with a strong background in molecular or cellular biology, biochemistry, or other related fields. The successful candidate will help design and conduct experiments, analyse data, write papers and grants. Projects involve studying the novel mechanisms of replication stress and genome instability in cancers. An overview of research can be found at https://www.csi.nus.edu.sg/web/sriram/
Duties & Responsibilities
- Establish sequencing based assays to study DNA damage and replication stress.
- Perform experiments involving bench work and tissue culture.
- Analyse experiment data and interpret results properly.
- Present research findings at lab meetings and seminars.
- Contribute to collaborative projects.
- Take a lead role in wet-lab management.
Requirements
- A Ph.D. in cancer biology or related area.
- Expertise in cancer biology and cancer genomics preferred.
- Strong background and working knowledge of basic molecular and cellular biology techniques, such as cell culture, cloning, real-time PCR and western blotting.
- Experience with various sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable.
- Excellent skills to communicate in written and spoken English.
Applications should include inside a single pdf document a CV, a summary of past research experience, a description of long term plans and names/contact information (including email) of 3 referees. Applications will be processed in a rolling basis. This position will remain open until filled or withdrawn.
Apply here.
Laboratory Executive/Research Assistant – Fluorescence Activated Cell Sorting (FACS) core – A/Prof Takaomi Sanda
A fulltime Laboratory Executive or Research Assistant position in the Fluorescence Activated Cell Sorting (FACS) Facility is available immediately. The successful candidate will aid the institute in providing flow cytometry service for users. The candidate can also choose to work on either research or administrative tasks under the supervision of A/Prof. Takaomi Sanda.
Requirements:
- University degree (biology, biomedical science, biotechnology or related area).
- Ability to speak and write well in English.
- Prior experience operating flow cytometry is required.
- Prior experience working with animal model (mouse and/or zebrafish) is preferable.
- Knowledge of: 1) basic principles and practices in the fields of biology, 2) principles, techniques and terminology used in biology.
- Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint.
Job scope:
1. Fluorescence Activated Cell Sorting (FACS) Facility
- To be in charge for the daily operation and maintenance of flow cytometry machines (analyzer and sorters).
- To provide flow sorting service for users.
- To provide technical advices for users.
- To ensure that the facility is adequately stocked with buffers, clean glassware, minor equipment, chemicals, etc. required for smooth operation of the facility.
- To ensure that standard operating procedures and safety regulations are followed.
- To record the utilization of flow cytometry machines and report to the institute.
2. *Research or Administrative Tasks
* The candidate can select either research track (appointed as a Research Assistant) or administrative tack (appointed as a Laboratory Executive).
2.a) Research tasks
- To maintain animal (mouse and/or zebrafish) colonies, including breeding and genotyping procedures.
- To monitor phenotypes (e,g, tumor development, hematopoietic phenotypes).
- To isolate tissues (e.g., bone marrow, thymus, spleen) from the animals.
- To harvest cells, protein, RNA or DNA from animal tissues, cell lines or bacteria.
- To perform experiments including PCR, immunoprecipitation and Western blot.
b) Administrative tasks
- To liaise with the central operation team, committees and the administrative office to assist the lab.
- To maintain a systematic and proper record of documents (e.g., budget spending).
- To maintain the CSI virus rooms.
- To be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project.
- To liaise with the vendors to ensure proper purchase requisitions, goods delivery and prompt payment of supplies.
Applications should include full curriculum vitae and indicate the names of at least 2 referees
Apply here.
Research Fellow - Prof Daniel Tenen
A postdoctoral position is available immediately for an extremely motivated Ph.D. or M.D with a strong background in molecular or cellular biology, biochemistry, or other related fields. The successful candidate will help to design and conduct experiments, analyse data, write papers and grants, including fellowships, and mentor and direct PhD students. Projects involve RNA biology with relevance to cancer, the oncofetal protein SALL4 in cancer, or both; a list of publications can be found at http://www.ncbi.nlm.nih.gov/pubmed/?term=Tenen+DG
Qualifications:
- A Ph.D. in cancer biology or related area, or M.D. with equivalent research experience
- Expertise in RNA biology preferred
- Strong background and working knowledge of basic molecular and cellular biology techniques, such as cell culture, cloning, real-time PCR and western blotting
- Experience with analyses of human clinical samples, RNA sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable
- A proven track record in the form of publications in top international English language journals
- Ability to communicate in written and spoken English
Applications should include an NIH style biosketch, and names and contact information (including telephone numbers) of 3 referees. Request that letters of recommendation be sent to daniel.tenen@nus.edu.sg (informal email recommendations are fine). Include a summary of your past research experience, a description of your long term plans, as well as ideas for at least two projects that you might want to work on in Dr. Tenen’s lab (half page each is fine, have fun with this!).
Research Assistant - Prof Lee Soo Chin
Job Description
To provide support to the Principal Investigator in research projects, maintenance of laboratory inventory and administration. Research duties and responsibilities will include:
- assisting to develop and carry out experiments and performing biological, hemotological, chemical, or physical analysis and determinations as tasked
- organizing, preserving and presenting the results of the experiments in a logical manner to supervisors or in research meetings
- assist in supervising, training and guiding attachment/undergraduate students where required
- performing surgical procedures, geno-typing, post-mortem examinations, tissue collection activities, etc. involving laboratory animals, and when necessary to make injections and dissections
- cooperate in maintaining and planning for the needs of the lab team as well as to meet administrative duties that are assigned.
Key Responsibilities
- To carry out assigned experiments, record, organize and present experimental results in a logical manner
- To ensure that standard operating procedures and safety regulations in the laboratory are followed
- To assist in supervising, training and guiding attachment/ students if necessary
- To plan and ensure overall laboratory administrative needs are met and maintain a systematic and proper record of all purchases
- To maintain patient-derived organoids/xenograft lines and keep proper records for all lines established
Qualifications
Honors degree (2nd upper class and above) in Life Sciences or similar field.
Candidates with 3-4 years of experience in a cancer biology laboratory and/or postgraduates will have an advantage.
Job Requirements
- Conduct independent reading and literature review to understand the project and the basis of each experiment
- Performs experiments, analyse and interpret scientific data independently
- Able to multi-task, well organized, and acquire good time management skills
- Communicates clearly and effectively in written and oral scientific presentations
Apply here.
Senior Research Scientist - Prof Daniel Tenen
A position is available immediately for an extremely motivated Ph.D., M.D., or M.D./Ph.D. with a strong background in bioinformatics. The successful candidate will help to design experiments, analyse data, write papers and grants, including fellowships, and mentor and direct PhD students. Projects involve RNA biology with relevance to cancer, the oncofetal protein SALL4 in cancer, or both; a list of publications can be found at http://www.ncbi.nlm.nih.gov/pubmed/?term=Tenen+DG
Qualifications:
- A Ph.D., M.D., or combined with research experience from postdoctoral work
- Expertise in RNA biology preferred
- Strong background and working knowledge of bioinformatic analysis
- Basic molecular and cellular biology knowledge desirable but not necessary
- Experience with analyses of human clinical samples, RNA sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable
- A proven track record in the form of publications in top international English language journals
- Ability to communicate in written and spoken English
Applications should include curriculum vitae, publication list, and names and contact information (including telephone numbers) of 3 referees. Request that letters of recommendation be sent to daniel.tenen@nus.edu.sg (informal email recommendations are fine). Include a summary of your past research experience, a description of your long term plans, as well as ideas for at least two projects that you might want to work on in Dr. Tenen’s lab (half page each is fine, have fun with this!).
Please note that only shortlisted candidates will be contacted.
Apply here.
Career Accelerator Postdoctoral Fellowship
The Cancer Science Institute of Singapore (CSI) Career Accelerator Postdoctoral Fellowship invites outstanding applicants at the level of early-stage postdoctoral fellows. The awardees will be hosted within established research labs to develop their independent research programs and collaborate with other exceptional researchers. They will receive a competitive salary package with an annual research grant of up to SGD$25,000 per year and equipment grant of SGD$5,000. Access to state-of-the-art core facilities will be provided. The tenure is up to three years.
Applicants should fulfil the following criteria:
- Have completed a PhD within the last 18 months from time of submission of application, or to have received their PhDs by the time they commence the fellowship
- Work in any discipline of cancer research,
- Excellent track record of research accomplishments,
- Keen to embark on exciting and innovative projects in experimental and/or bioinformatics laboratories,
- Aspire to be leaders in biomedical research
Interested applicants should submit the following to csi_recruitment@nus.edu.sg or attach the following documents in your application. Please indicate “Application for CSI Career Accelerator Postdoctoral Fellowship” in the subject title. Only shortlisted candidates will be contacted.
- Cover letter,
- Curriculum Vitae (CV), including full publication list,
- Official transcript or Degree Certificate in English (PhD’s degree),
- Names and contact information (email and phone number) of 2 – 3 references (including PhD supervisor),
- Top 3 publications (in PDF), and
- Two-page research proposal (excluding references) summarising the background, significance, and aims and methods of the proposed research.
Apply via: https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=6350&company=nationalunP2
Senior Research Scientist - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on structural biology?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Senior Research Scientist to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
This position will be jointly under Dr. Tan Yong Zi, who is an expert on single-particle cryogenic electron microscopy (cryo-EM) (see https://www.tyzlab.com/). His lab is a core member of the Centre for BioImaging Sciences’ (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. The aim of this joint position is to use cryo-EM to help solve the structures of many exciting cancer complexes to help with potential drug development.
Duties and Responsibilities
The position exists to provide
- Optimisation and performance of structural biological related experiments and projects, particularly in the field of cryo-electron microscopy
- Sample Vitrification:
- Proteins will be produced separately, hence experience in protein production is not required, although favoured
- Candidate will be responsible for optimisation of the vitrification of grids
- Data Collection:
- Candidate will oversee collecting screening and high resolution cryo-EM data from the T12 and Krios
- Data analysis:
- Candidate will oversee processing the data and producing cryo-EM maps from high resolution Krios data collections
- Candidate will help setup the processing pipeline for CSI
- Education:
- Oversee training personnel from both CSI and Tan lab on cryo-EM
Qualifications
- PhD in cryo-EM or structural biology related field
- Firm understanding of the principles of cryo-EM
- Experience in single-particle cryo-EM sample vitrification, data collection and data processing
- Good publication record
- Excellent written and spoken English
- Friendly and personable
Please apply here.
Research Scientist - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on structural biology?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Senior Research Scientist to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
This position will be jointly under Dr. Tan Yong Zi, who is an expert on single-particle cryogenic electron microscopy (cryo-EM) (see https://www.tyzlab.com/). His lab is a core member of the Centre for BioImaging Sciences’ (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. The aim of this joint position is to use cryo-EM to help solve the structures of many exciting cancer complexes to help with potential drug development.
Duties and Responsibilities
The position exists to provide
- Optimisation and performance of structural biological related experiments and projects, particularly in the field of cryo-electron microscopy
- Sample Vitrification:
- Proteins will be produced separately, hence experience in protein production is not required, although favoured
- Candidate will be responsible for optimisation of the vitrification of grids
- Data Collection:
- Candidate will oversee collecting screening and high resolution cryo-EM data from the T12 and Krios
- Data analysis:
- Candidate will oversee processing the data and producing cryo-EM maps from high resolution Krios data collections
- Candidate will help setup the processing pipeline for CSI
- Education:
- Oversee training personnel from both CSI and Tan lab on cryo-EM
Qualifications
- PhD in cryo-EM or structural biology related field
- Firm understanding of the principles of cryo-EM
- Experience in single-particle cryo-EM sample vitrification, data collection and data processing
- Good publication record
- Excellent written and spoken English
- Friendly and personable
Please apply here.
Research Fellow (Bioinformatician) - A/Prof Polly Chen
A postdoctoral position is available immediately in A/Prof Polly Chen’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of A/P Polly Chen’s lab is on the transcriptome-wide identification of RNA changes (e.g., RNA editing, alterative splicing, altered protein-RNA interactions, etc) in tumors and functional investigation of these changes in cancer.
Duties and Responsibilities
Candidates should have strong background in bioinformatics, genomics/transcriptomics, computer science, statistics, or other related fields. Those who are interested in computational genomics and transcriptomics, particularly in analysis and integration of various genomics/transcriptomics data, are encouraged to apply. The successful candidate will analyze and integrate in-house NGS datasets (bulk and single-cell RNA-seq, spatial transcriptomics, DNA-seq, eCLIP-seq, MeDIP-seq, etc) and also utilize publicly available genomic/transriptomics/clinical data sets to identify novel biological biomarkers/patterns and regulatory mechanisms.
Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R, or other related programming knowledge), and excellent skills in handling genomic, transcriptomic and proteomic databases. Experience in analyzing RNA editing, alternative splicing, RNA binding sites using the bulk and single-cell RNA-seq, eCLIP-seq, spatial transcriptomic data is a plus.
Qualifications
- A PhD graduate with relevant experience in areas of computational biology/bioinformatics
- Extensive knowledge and experience in working with a variety of NGS datasets, pipeline development and algorithm development
- Strong publication track record, indicated by first author publications in high quality journals
- Strong analytical skills and programming skills
- Ability to write/contribute to research articles, grants and keep meticulous notes/proper scientific documentation
- Strong interpersonal, written and oral communication skills
- A strong team focus and ability to work independently
Please apply here.
Research Fellow/Senior Research Scientist (Bioinformatician, Cancer Science Institute) - Prof Chng Wee Joo
A postdoctoral/SRS position is available immediately in Prof Chng Wee Joo’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of the lab is on deciphering transcriptional and genomic abnormalities in the context of blood cancer, including epigenetic and superenhancer deregulation, using single cell sequencing amongst other genomics techniques.
Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis of single cell sequencing data, superenhancer and chromatic interaction data, and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (RNA-seq, small RNA-seq, microarray etc) data sets and also utilize publicly available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms.
Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R or other related programming knowledge), and excellent skills in handling Linux clusters and genomic databases. Experience in analyzing single cell and/or long-read sequencing data is ideal but not required.
Applications should send full curriculum vitae (not more than 3 pages) and the names, addresses and contact numbers of 3 professional references.
Apply here.
Research Fellow - Dr Dennis Kappei
We are seeking a highly motivated candidate as a research fellow in the Quantitative Proteomics Core in collaboration with the Kappei lab at the Cancer Science Institute of Singapore (CSI). Our team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study protein expression, protein interactions as well as post-translational modifications.
Proteins are the functional agents in cells, yet the systematic global characterization of their expression and spatial distribution has largely remained limited to the analysis of RNA as a proxy. To close this gap, we have recently expanded the Quantitative Proteomics Core to Clinical Proteomics applications with dedicated instruments including a timsTOF fleX mass spectrometer that allows for dual LC-MS/MS and MALDI imaging analysis. The research fellow will develop innovative workflows for both untargeted and targeted spatial protein imaging applied to the analysis of cancer tissues. We are offering a position in a stimulating, diverse and international research environment as well as the opportunity to gain expertise in a highly demanded technology using state-of-the-art instruments.
Requirements:
- PhD in life sciences, chemistry, medicine or related fields
- Strong background and working knowledge of basic molecular and biochemical techniques
- Excellent communication skills and good team spirit
- Ability to solve problems independently
- Penchant for method development
- Strong publication record
- Preference will be given to candidates with
- Experience with mass spectrometry (sample preparation and instrument operation/maintenance)
- Experience with image analysis and/or histology
Applications should include in a single PDF a 1-page cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Clinical Proteomics RF” to:
Dr. Dennis Kappei
Principal Investigator
CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Further information on the Cancer Science Institute of Singapore as well as working at CSI can be found on our website: www.csi.nus.edu.sg/web/careers/
Please apply here.
Research Fellow (Bioinformatician) - Dr Jason Pitt
The position of Postdoctoral Fellow (PDF) in computational cancer genomics is immediately available at The Cancer Science Institute of Singapore (The National University of Singapore). This PDF will lead a newly funded project in the laboratory of Dr. Jason Pitt that will explore how germline genetics and cell-of-origin contribute to genomic instability (GI) in cancer (see Pitt et al., 2018, Nat Comms; Pitt et al., 2018, Cancer Cell; Wang & Pitt et al., 2019, Int J Cancer). The acquisition of GI by malignant cells is critical to cancer development and progression. However, the magnitude and type of GI can vary widely across patients and cancer types. Delineating the underlying sources of GI will help identify novel therapeutic biomarkers (Pitt, Hoppe, & Jeyasekharan; PCT/SG2021/050105). The PDF will build upon our recently developed computational framework to derive dozens of GI scores and copy number signatures from tens of thousands of malignant samples. Using a multi-omic approach, these scores will be associated with clinical, genomic, and cell-type specific features. Candidate genes/variants will be investigated experimentally using CRISPR-mediated isogenic cell lines.
ROLES AND RESPONSIBILITIES
- Processing and management of public genomic data (WES, RNAseq, SNP array, etc.)
- Develop methods to estimate CN-based GI scores and signatures
- Use innovative approaches to associate inherited variation with GI patterns
- Determine the relationship between GI patterns and phenotypic features
- Lead manuscript writing and software documentation
- This position is for 2-3 years with the possibility of extension
REQUIREMENTS
- PhD in human genetics, genomics, bioinformatics, or related fields
- Firm understanding of human genetics and association studies
- Experience analyzing cancer genomics data
- Strong Python and/or R programming skills
- Penchant for statistical reasoning
- Strong publication record
- Excellent written and spoken English
PREFERENCES
- Familiarity with copy number and mutation signature analysis
- Experience using Amazon Web Services or high-performance computing
- Proficiency with Unix-based systems
- Experience with collaborative software development via github/gitlab
Apply here.
Research Fellow (Bioinformatician) – Dr Jason Pitt
BACKGROUND
The position of Postdoctoral Fellow with an emphasis on cancer genomics and bioinformatics is immediately available in the laboratory of Dr. Jason Pitt, which integrates data science and biological expertise to facilitate precision oncology. The Pitt Laboratory achieves this by developing cutting-edge software that allows rapid interrogation and interpretation of large genomic datasets. This position is connected to the Cancer Science Institute (CSI) Translational theme, which is building knowledge-bases and algorithms to recommend cancer treatments based on a patient’s genetic profile. This fellow will also work closely with clinician-scientist Dr. Anand Jeyasekharan to help facilitate molecular tumor boards at National University Hospital. An experienced genome analyst will have the unique opportunity to impact real-world precision oncology while developing skills in cloud computing, data science, and augmented intelligence.
RESPONSIBILITIES
Candidate will work with the CSI Translational Team to deliver the following:
- Aggregation and analysis of publicly available datasets
– Data wrangling of genomics and clinical datasets
– Processing and analysis of NGS data (e.g. DNA- & RNA-seq)
– Apply novel prediction algorithms over large-scale data - A knowledge graph for precision oncology
– Integrate drug, protein/gene, clinical trial, and genomics data
– Overlay analytics to discover novel biological and clinical insights
– Facilitate oncologist queries based on an entity of interest
REQUIREMENTS
- Ph.D. in bioinformatics, genomics, computer science, information systems, statistics, or related fields
- Experience analyzing data derived from high-throughput technologies
- Strong Python programming skills and proficiency with Unix-based systems
- Strong analytical and critical thinking skills
- Evidence of leading projects to completion
- Excellent written and spoken English
PREFERENCES
- Previous experience with cancer genomics data
- Familiarity with Amazon Web Services
- Database management experience (SQL, NoSQL, Elasticsearch, etc.)
- Experience with collaborative software development via github/gitlab
HOW TO APPLY
Applications should include full curriculum vitae, publication list (if applicable), and contact information for 2-3 referees. Please also include a single page cover letter summarizing your previous research, analytical/programmatic expertise, and why this position is of interest to you.
Apply via:
https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=5336&company=nationalunP2
Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg
Recruitment Brochure
