The position of Postdoctoral Fellow (PDF) — with an emphasis on computational cancer genomics — is immediately available at The Cancer Science Institute of Singapore (a part of The National University of Singapore). The postholder will work with the laboratories of Prof. Ashok Venkitaraman, Dr. Jason Pitt and Prof. Touati Benoukraf on a project studying the evolution of cancer genomes during early steps in carcinogenesis, with the long-term aim to develop better methods for early intervention.

This is an exciting opportunity to deploy expertise in computational biology in an active multidisciplinary environment, working closely with experimental cancer biologists to address major scientific problems.

The postholder will apply existing analytic pipelines and devise new algorithms to explore data derived from multiple DNA sequencing technologies (eg., Illumina & Nanopore) to resolve cancer genome evolution at the clonal level. S/he will also analyse complementary data from other technologies, ranging from single-cell RNAseq to chromatin immunoprecipitation to chromatin accessibility (ATAC-seq), using a variety of novel cellular models established in Prof. Venkitaraman’s laboratory. Experimental findings will be explored and validated using clinical genomic datasets.

A PhD in a relevant field, with a strong track record of achievement exemplified by publications, is important, as is the required expertise in computational biology listed below. Experience in the methods to be used in the project is desirable.

Requirements:

• PhD in human genetics, genomics, bioinformatics, computer science, or related fields
• Firm understanding of the principles of clonal evolution
• Experience analyzing DNA sequencing data
• Strong Python and/or R programming skills
• Proficient with standard statistical analyses
• Strong publication record
• Excellent written and spoken English

Preferences:

• Experience using Amazon Web Services
• Proficiency with Unix-based systems
• Experience with collaborative software development via github/gitlab

Please click here to apply.

A postdoctoral position is available immediately in Prof. Yoshiaki Ito’s lab. The successful candidate will study one of the following on-going projects.

1) Characterization of two types of stem cells in stomach.

It is widely accepted that cancer originates from aberrant regulation of tissue stem cells.  However, studies of tissue stem cells in many organs are still at early stages.  There are two types of stem cells in stomach:  rapidly proliferating stem cells (Isthmus stem cells) and dormant stem cells, a subpopulation of terminally differentiated chief cells at the gland base.  Isthmus stem cells are responsible for generating all cell types in the stomach under the homeostatic conditions.  We recently identified cytoskeletal scaffold protein, IQGAP3, as a highly specific isthmus stem cell factor during homeostasis (GUT, 2020).  We further found that upon tissue damage, IQGAP3 was robustly induced in dormant stem cells, which acquired proliferating capacity to engage in tissue repair.  The objective is detailed molecular characterization of these two types of stem cells.

2) IQGAP3 is also widely expressed in rapidly proliferating areas of gastric cancer. We call IQGAP3 the “common denominator of homeostasis, tissue repair and cancer”.  Tumors have been described as “wounds that do not heal (Dvorak, 1986)”. We will investigate the possibility that elevated IQGAP3 expression during chronic tissue damage induces cell plasticity and redirects cell fate to drive malignant transformation.

3) We have identified transcription factors responsible for the exclusive expression of IQGAP3 in stem cells. We have also found the proteins that interact with and stabilize the IQGAP3 mRNA in stem cells.  We will study the role of IQGAP3 in the formation of stomach epithelial stem cells during development.  Conversely, we found that depletion of these transcription factors in undifferentiated cancer cells induced differentiation as well as reduced cancer cell properties.  Understanding how these factors regulate IQGAP3 will lead to novel insights on induction of terminal differentiation as cancer therapy for aggressive tumor types.

4) The fact that IQGAP3 is expressed not only in gastric but virtually all other types of cancer cells indicates a fundamental role for IQGAP3 in cancer growth. Developing drugs to inhibit IQGAP3 activity will be important.

We seek a highly motivated and innovative postdoctoral fellow with the ability to work independently and as part of a team. Candidates should have PhD and/or MD degree with a strong background in molecular biology, biochemistry and cell biology.   Prior experience with using mouse models to study cancer and 1-2 years of postdoctoral experience in these areas are required.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 2 referees. Please also include a summary of your research experience.

Kindly send your application to:

April Chan (aprilchy@nus.edu.sg)
Cancer Science Institute, National University of Singapore

The position will provide oversight, management and support for the research, laboratory and administrative needs of the Principal Investigator and his team.

Duties & Responsibilities

Research:

• To derive, maintain and CRISPR engineer 3D organoid cultures from a variety of tissue systems
• To carry out assigned molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations as tasked
• To organise, preserve and present the results of the experiments in a logical manner
• To properly and systematically record all experiments that have been assigned and their results
• To assist in supervising, training and guiding attachment/undergraduate students where required

Lab Management:

• Maintain up to date records of inventories for chemical/ biological reagents
• Assist when required with procurement
• Ensure tidiness and cleanliness of the lab is maintained

Requirements

• University degree in a relevant field
• Ability to speak and write clearly in English
• 2 to 3 years work experience in a molecular biology lab; experience with organoid cultures is desirable
• Knowledge of:
  • Basic principles and practices in the fields of biology.
  • Principles, techniques and terminology used in cancer biology.
  • Methods of scientific research and relevant scientific theories.
  • Appropriate computer operations, software and peripherals.
  • General rules for safe exposure and handling of chemical and biological hazards
  • IRB, OSHE & IACUC regulations
  • Principles, techniques and terminology used in organoid model systems and genomic and RNA sequencing as well as common lab molecular and cell biology techniques (desirable)
• Ability to:
  • Perform laboratory tests in an efficient and timely manner
  • Work cooperatively and effectively with others

Kindly send in your application via this link.

The Cancer Science Institute of Singapore (CSI) Career Accelerator Postdoctoral Fellowship invites outstanding applicants at the level of early-stage postdoctoral fellows. The awardees will be hosted within established research labs to develop their independent research programs and collaborate with other exceptional researchers. They will receive a competitive salary package with an annual research grant of up to SGD$25,000 per year and equipment grant of SGD$5,000. Access to state-of-the-art core facilities will be provided. The tenure is up to three years.

Applicants should fulfil the following criteria:

• Have a PhD degree within the prior 18 months from the deadline of the application or to have received their PhDs by the time they commence the fellowship,
• Work in any discipline of cancer research,
• Excellent track record of research accomplishments,
• Keen to embark on exciting and innovative projects in experimental and/or bioinformatics laboratories,
• Aspire to be leaders in biomedical research

Interested applicants should submit the following to csi_recruitment@nus.edu.sg. Please indicate “Application for CSI Career Accelerator Postdoctoral Fellowship” in the subject title. Only shortlisted candidates will be contacted.

1. Cover letter,
2. Curriculum Vitae, including full publication list,
3. Two-page research proposal (excluding references) summarising the background, significance, and aims and methods of the proposed research,
4. Names and contact information (email and phone number) of 2 – 3 references (including PhD supervisor),
5. List of potential host labs contacted.

Apply via: https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=6350&company=nationalunP2

A postdoctoral position is available immediately for an extremely motivated Ph.D. or M.D with a strong background in molecular or cellular biology, biochemistry, or other related fields. The successful candidate will help to design and conduct experiments, analyse data, write papers and grants, including fellowships, and mentor and direct PhD students. Projects involve RNA biology with relevance to cancer, the oncofetal protein SALL4 in cancer, or both; a list of publications can be found at http://www.ncbi.nlm.nih.gov/pubmed/?term=Tenen+DG

Qualifications:

• A Ph.D. in cancer biology or related area, or M.D. with equivalent research experience
• Expertise in RNA biology preferred
• Strong background and working knowledge of basic molecular and cellular biology techniques, such as cell culture, cloning, real-time PCR and western blotting
• Experience with analyses of human clinical samples, RNA sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable
• A proven track record in the form of publications in top international English language journals
• Ability to communicate in written and spoken English

Applications should include curriculum vitae, publication list, and names and contact information (including telephone numbers) of 3 referees. Request that letters of recommendation be sent to daniel.tenen@nus.edu.sg (informal email recommendations are fine). Include a summary of your past research experience, a description of your long term plans, as well as ideas for at least two projects that you might want to work on in Dr. Tenen’s lab (half page each is fine, have fun with this!).

Please note that only shortlisted candidates will be contacted.

BACKGROUND

The position of Postdoctoral Fellow with an emphasis on cancer genomics and bioinformatics is immediately available in the laboratory of Dr. Jason Pitt, which integrates data science and biological expertise to facilitate precision oncology. The Pitt Laboratory achieves this by developing cutting-edge software that allows rapid interrogation and interpretation of large genomic datasets. This position is connected to the Cancer Science Institute (CSI) Translational theme, which is building knowledge-bases and algorithms to recommend cancer treatments based on a patient’s genetic profile. This fellow will also work closely with clinician-scientist Dr. Anand Jeyasekharan to help facilitate molecular tumor boards at National University Hospital. An experienced genome analyst will have the unique opportunity to impact real-world precision oncology while developing skills in cloud computing, data science, and augmented intelligence.

RESPONSIBILITIES

Candidate will work with the CSI Translational Team to deliver the following:

1. Aggregation and analysis of publicly available datasets
   – Data wrangling of genomics and clinical datasets
   – Processing and analysis of NGS data (e.g. DNA- & RNA-seq)
   – Apply novel prediction algorithms over large-scale data
2. A knowledge graph for precision oncology
   – Integrate drug, protein/gene, clinical trial, and genomics data
   – Overlay analytics to discover novel biological and clinical insights
   – Facilitate oncologist queries based on an entity of interest

REQUIREMENTS

• Ph.D. in bioinformatics, genomics, computer science, information systems, statistics, or related fields
• Experience analyzing data derived from high-throughput technologies
• Strong Python programming skills and proficiency with Unix-based systems
• Strong analytical and critical thinking skills
• Evidence of leading projects to completion
• Excellent written and spoken English

PREFERENCES

• Previous experience with cancer genomics data
• Familiarity with Amazon Web Services
• Database management experience (SQL, NoSQL, Elasticsearch, etc.)
• Experience with collaborative software development via github/gitlab

HOW TO APPLY

Applications should include full curriculum vitae, publication list (if applicable), and contact information for 2-3 referees. Please also include a single page cover letter summarizing your previous research, analytical/programmatic expertise, and why this position is of interest to you.

Apply via:

https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=5336&company=nationalunP2

Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg

Are you a biomedical graduate seeking an exciting lab support role?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to better understand the causes of human cancer across Asia, and thereby improve its detection, treatment and prevention. Our outstanding researchers and exceptional facilities create an energetic environment for ground-breaking science and world-class training. A supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Research Assistant to join the team of our new Director, Prof. Ashok Venkitaraman, who has joined us from the University of Cambridge (see https://www.csi.nus.edu.sg/web/csi-singapore-welcomes-new-director-professor-ashok-venkitaraman/). This is an exciting opportunity to work in a key role providing oversight, management and support for the research, laboratory and administrative needs of a world-leading cancer research team.

Essential qualifications:

• University degree in a relevant field
• 2 to 3 years work experience in a molecular biology lab; experience with murine models is desirable
• Basic principles and practices in the fields of biology, physiology and/or chemistry
• Ability to speak and write clearly in English.

Preference will be given to candidates with knowledge of:

• Quality assurance procedures applicable to a laboratory.
• Principles, techniques and terminology used in cancer biology.
• Laboratory scientific resource material; laboratory equipment and its care.
• Methods of scientific research and relevant scientific theories.
• Government guidelines and regulations pertinent to laboratory safety and security.
• Packaging and shipping of diagnostic, infectious and hazardous materials.
• Appropriate computer operations, software and peripherals.
• General rules for safe exposure and handling of chemical and biological hazards
• IRB, OSHE & IACUC regulations
• Principles, techniques and terminology used in the examination of clinical and animal samples as well as common lab techniques required for work on laboratory animals

More information on careers in NUS can be found at http://www.nus.edu.sg/careers/

Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Applications will be considered until 16 March 2021 or until the position is filled.
We will only contact candidates whose qualifications meet the criteria listed.

Are you a biomedical researcher motivated to pursue an outstanding career in cancer research?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Research Fellow to join the team of our new Director, Prof. Ashok Venkitaraman, who has recently joined us from the University of Cambridge (see https://www.csi.nus.edu.sg/web/ashok-venkitaraman/). This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).

ESSENTIAL qualifications include: (1) a PhD, (2) strong track record of research achievement evidenced by high-quality publications in a relevant field, (3) high-level experience in hands-on use of a wide range of relevant research methods, (4) skills in working independently and creatively to solve experimental problems and (5) effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.

Preference will be given to candidates with: (1) Previous experience in computational approaches to the analysis of (epi)genomic, transcriptomic or proteomic alterations in cancer or other diseases; (2) Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy, or (3) Previous experience with genetically engineered murine models.

More information on careers in NUS can be found at http://www.nus.edu.sg/careers/

Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
To apply for this position, please visit this link here.
Website: www.csi.nus.edu.sg

Applications will be considered until 2 January 2021 or until the position is filled.
We will only contact candidates who are shortlisted.

Are you a biomedical researcher motivated to pursue an outstanding career in cancer research?

Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.

We now seek a Senior Research Scientist to join the team of our new Director, Prof. Ashok Venkitaraman, who has recently joined us from the University of Cambridge (see https://www.csi.nus.edu.sg/web/ashok-venkitaraman/). This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).

ESSENTIAL qualifications include: (1) a PhD with 3 years’ relevant post-doctoral experience, (2) strong track record of research achievement evidenced by high-quality publications in a relevant field, (3) high-level experience in hands-on use of a wide range of relevant research methods, (4) skills in working independently and creatively to solve experimental problems and (5) effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.

Preference will be given to candidates with: (1) Previous experience in computational approaches to the analysis of (epi)genomic, transcriptomic or proteomic alterations in cancer or other diseases; (2) Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy, or (3) Previous experience with genetically engineered murine models.

More information on careers in NUS can be found at http://www.nus.edu.sg/careers/

Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:
Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg

Applications will be considered until the position is filled.
We will only contact candidates who are shortlisted.

A fulltime Research Fellow position will be available after January 2021.

The primary focus of our laboratory is to understand the mechanism of transformation by aberrant activation of oncogenic transcription factors in leukemia and other cancers.  We are seeking highly motivated graduates. Candidates should have a PhD degree in molecular biology, cancer biology, medicine, bioinformatics, computational biology, computer science, or related fields.

1. For experimental study position (wet lab work), candidates will work on molecular biological and sequencing experiments (ChIP-seq, RNA-seq, ATAC-seq, Hi-C, whole genome sequencing), and animal models to study cancer biology and normal development. Prior experiences in the use of mouse or zebrafish model as well as basic molecular biology techniques are required.
2. For bioinformatics position (dry lab work), candidates will work on large scale genomic and transcriptomic data from next generation sequencing (ChIP-seq, RNA-seq, ATAC-seq, Hi-C, whole genome sequencing). Knowledge for optimization and statistical packages and programming (e.g., Python, Perl, C, C++, Java, R, or other related programming knowledge) are

The ability to work independently and design and interpret experiments is essential, together with excellent organizational skills and fluency in English.  We are looking for a team- and goal-oriented personality who wants to work in a young and international team.  Research Fellow will be encouraged to present data at internal and external meetings and publish in peer-reviewed journals.

Applications should include full curriculum vitae, publication list, information on years of experience in research work, and names and contact information (e-mail and telephone numbers) of 3 references.  Inclusion of a summary of your research experience and a brief paragraph on why you want to join the Sanda lab is highly suggested.

Please note that only shortlisted candidates will be contacted.

Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
To apply for this position, please visit this link here.
Website: www.csi.nus.edu.sg

A postdoctoral position is available immediately in A/Prof Henry Yang and Dr Yvonne Tay’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of the lab is on deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Cell 2011; Chan et al, NAR 2018).

Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (RNA-seq, small RNA-seq, microarray etc) data sets and also utilize publicly available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms. Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R or other related programming knowledge), and excellent skills in handling Linux clusters and genomic databases. Experience in analyzing single cell and/or long-read sequencing data is ideal but not required.

Applications should send full curriculum vitae (not more than 3 pages) and the names, addresses and contact numbers of 3 professional references to csiyangh@nus.edu.sg and yvonnetay@nus.edu.sg with the subject title – ‘Application for HY/YT postdoc position’.