Research Positions Available
Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.
Research
Research Assistant (Bioinformatician) - Dr Sriram Sridharan
Job Description
A Bioinformatics Research Assistant position is available immediately at the Cancer Science Institute (a part of The National University of Singapore) in the laboratory of Dr. Sriram Sridharan. The research will focus in the broad area of replication stress, DNA damage and genome integrity.
This is an exciting opportunity to deploy expertise in computational biology in an active multidisciplinary environment. The candidate will work closely with the PI to develop novel bioinformatics pipeline(s) to analyze and integrate unpublished/publicly available genomic(s) datasets. The objective is to identify new biomarkers as well as to generate experimentally testable hypotheses. The generated biomarkers and hypotheses will be tested in clinical/experimental datasets in collaboration with wet-lab scientists.
Duties And Responsibilites
• Bioinformatics
o Utilize and/or develop novel computational algorithms and tools
o Aggregation and analysis of genomic(s) datasets
o Investigate findings in experimental/clinical datasets
Qualifications
• Basic requirements
o Bachelors or Masters degree in computer science, bioinformatics, engineering, mathematics, or related fields
o Python, bash and/or R programming skills
o Strong analytical and critical thinking skills
o Excellent written and spoken English
• Preferred qualifications
o Experience with Unix-based systems
o Experience analysing data derived from high-throughput technologies
o Motivation to learn new and relevant biology
o Experience using HPC systems
For full consideration, please submit the following to Dr. Sriram Sridharan via email at srirvs@nus.edu.sg
o a single page cover letter summarizing your experience, programmatic expertise, and why this position is of interest to you
o full curriculum vitae and
o contact information for 2 referees
The position will remain open until filled or withdrawn.
Apply here.
Research Fellow (Bioinformatician) - Dr Sriram Sridharan
Job Description
A Bioinformatics Postdoctoral Fellow (PDF) position is available immediately at the Cancer Science Institute (a part of The National University of Singapore) in the laboratory of Dr. Sriram Sridharan. The research will focus in the broad area of replication stress, DNA damage and genome integrity.
This is an exciting opportunity to deploy expertise in computational biology in an active multidisciplinary environment. The PDF will develop novel bioinformatics pipeline(s) to analyze and integrate unpublished/publicly available genomic(s) datasets. The objective is to establish new biomarkers as well as to generate experimentally testable hypotheses. The generated biomarkers and hypotheses will be tested in clinical/experimental datasets in collaboration with wet-lab scientists.
Duties And Responsibilities
• Bioinformatics
o Utilize and/or develop novel computational algorithms and tools
o Aggregation and analysis of unpublished/publicly available datasets
o Investigate findings in experimental/clinical datasets
Qualifications
• Basic requirements
o PhD in genomics, bioinformatics, computer science, engineering or related fields
o Experience analysing data derived from high-throughput technologies
o Strong Python, bash and/or R programming skills
o Proficient with standard statistical analyses
o Experience with Unix-based systems
o Motivation to learn new and relevant biology
o Strong analytical and critical thinking skills
o Excellent written and spoken English
• Preferred qualifications
o Experience using HPC systems
For full consideration, please submit the following to Dr. Sriram Sridharan via email at srirvs@nus.edu.sg
o a single page cover letter summarizing your experience, programmatic expertise, and why this position is of interest to you
o full curriculum vitae, including list of publications and
o contact information for 3 referees
The position will remain open until filled or withdrawn.
Apply here.
Research Assistant (Bioinformatician) - Dr Jason Pitt
The position of DevOps Software Engineer is immediately available in the Genome and Data Analytics Core (GeDaC) at the Cancer Science Institute of Singapore (CSI) — a part of National University of Singapore. The CSI GeDaC is building a platform to facilitate the automated processing and analysis of large cancer genomics datasets. Successful candidates, in conjunction with bioinformatics experts, will build and optimize various components of this platform. This position provides a unique opportunity to apply DevOps skills to Amazon Web Services (AWS), data-intensive computing, and artificial intelligence to drive novel discoveries in cancer genomics.
Duties And Responsibilities
Participate in the continued development of:
- Deploy and optimize of scalable genome processing workflows on AWS
- Facilitate cost-effective analytics via AWS microservices and serverless architecture (Lambda, Fargate, Aurora, etc.)
- Assist with database design, implementation, and management
- Enable unit testing and deployment automation (CI/CD)
- Help manage data ingress and egress to S3/Glacier
Qualifications
- Bachelors or Masters degree (minimally) in computer science, information systems, bioinformatics, engineering, mathematics, or related fields 2+ years of DevOps experience
- Strong Python programming skills and proficiency with Unix-based systems
- Experience with collaborative software development via github/gitlab
- Database management experience (SQL, NoSQL, Elasticsearch, etc.)
- Excellent written and spoken English
Preferences
- Some knowledge of biology and genetics
- Software development experience in industry
- Past projects using CI/CD tools on commercial clouds
- Experience with on-prem to cloud data migrations AWS certifications
Apply here.
Research Assistant - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on organoid research?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Assistant/ Associate to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
The role will provide expertise in the establishment, genetic manipulation and maintenance of human and murine organoid cultures as well as design/ perform and analyse work within the project parameters.
Duties and Responsibilities
Research:
- To establish, engineer (e.g. by CRISPR) and maintain 3D organoid cultures from a variety of tissue systems
- To carry out assigned molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations as tasked
- To organise, preserve and present the results of the experiments in a logical manner
- To properly and systematically record all experiments that have been assigned and their results
Lab Management:
- Maintain up to date records of inventories for chemical/ biological reagents
- Assist when required with procurement
- Ensure tidiness and cleanliness of the lab is maintained
Qualifications
- University degree in a relevant field
- Significant amount of experience working with human and/ or murine organoids
- Ability to speak and write clearly in English
- Experience with the establishment, engineering and maintenance of organoid cultures
- 2 to 3 years work experience in a molecular biology lab;
- Knowledge of:
- Basic principles and practices in the fields of biology.
- Principles, techniques and terminology used in cancer biology.
- Methods of scientific research and relevant scientific theories.
- Appropriate computer operations, software and peripherals.
- General rules for safe exposure and handling of chemical and biological hazards
- IRB, HBRA & IACUC regulations
- Principles, techniques and terminology used in organoid model systems and genomic and RNA sequencing as well as common lab molecular and cell biology techniques (desirable)
- Ability of:
- Perform laboratory tests in an efficient and timely manner
- Work cooperatively and effectively with others
Apply here.
Research Assistant - Dr Yong Wei Peng
Duties and Responsibilities
a) Research:
- To carry out assigned experiments
- To organise, preserve and present the results of the experiments in a logical manner
- To properly and systematically record all experiments that have been assigned and their results
- To analyse and plan further experiments under guidance
- To assist in supervising, training and guiding attachment/undergraduate students where required
b) Laboratory:
- To plan and ensure the needs and requirements of the team in terms of consumables
- To ensure that the lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for experiments
- Responsible for the cleanliness and maintenance of equipment through regular checks
- Required to assemble reagents, chemicals and media that are needed for experiments
- To ensure that standard operating procedures and safety regulations are followed
- Responsible for the general cleanliness of the lab
c) Administrative duties:
- To plan and ensure that the overall lab administrative needs of the PDO team are met
- To assist the Principal Investigator in tracking his/her grants and other sources of funding
- Responsible for purchasing necessary equipment, chemicals, reagents as required for PDO research
- Maintain a systematic and proper record of all purchases
- Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies
d) Any other duties as required
Qualifications
- Applicants should possess a BSc or MSc in biomedical science, life science, biochemistry, biotechnology, immunology or equivalent from a well-recognized university.
- Prior experience, knowledge and expertise in mammalian cell culture, cell biology, microscopy, molecular biology, immunology, histology, flow cytometry, biochemistry, statistics and/or bioinformatics.
- Experience handling human clinical specimens is highly desirable.
- Proficient in computer software and peripherals, including Microsoft Office and Prism.
- Self-driven, independent, team player, meticulous and have a keen eye for details.
- Willingness to learn new technologies and techniques, tackle both new and routine duties, meticulous, good organisational and management skills.
- Able to work well in an interdisciplinary and collaborative environment.
- Flexibility to adapt to dynamic work activities in a fast-changing environment and project priorities / timelines.
- Able to multitask and occasionally work at flexible hours when performing time-sensitive experiments.
- Excellent communication skills in spoken and written English.
- Strong passion and commitment to biomedical research in cancer immunology and cancer therapeutics.
- Willing to perform administrative duties.
Apply here.
Research Associate - A/Prof David Tan, Prof Shazib Pervaiz
We are seeking an enthusiastic and highly motivated Research Associate to aid in cell line development and maintenance at the NUS Centre for Cancer Research (N2CR) under the Tissue Specific Carcinogenesis (TSC) Theme.
Duties and Responsibilities
- Perform clinical cell lines preparation and development
- Assist and provide support in research projects utilizing patient-derived organoids (PDO)
- Assist with clinical sample accessioning, quality control, method development, process improvement, proficiency/competency training standards and schedules.
- Preparation of chemical stock solutions and reagents required for cell culture.
- Performs laboratory maintenance duties, organise and keep track of spending related to N2CR TSC Theme budget
- To store samples and record experimental procedures systematically and accurately, present analytical results in a logical manner.
- To support collaborative work within multidisciplinary team and external collaborators.
- To provide frequent updates and plan further analytical experiments under guidance.
Qualifications
- Applicants should possess a BSc/MSc in life sciences, biology, biochemistry, bioengineering or equivalent from a well-recognized university.
- Prior experience, knowledge and expertise in mammalian cell culture, cell biology, microscopy, molecular biology, immunology, histology, flow cytometry, biochemistry, statistics and/or bioinformatics.
- Experience handling human clinical specimens is highly desirable.
- Proficient in computer software, including Microsoft Word, Excel and PowerPoint, GraphPad.
- Self-driven, independent, team player, meticulous and have a keen eye for details.
- Willingness to learn new technologies and techniques, tackle both new and routine duties, good organisation and management skills.
- Able to work well in an interdisciplinary and collaborative environment.
- Flexibility to adapt to changing environment and project priorities / timelines.
- Able to work at flexible hours occasionally when performing time-sensitive experiments.
- Excellent written and verbal communication skills, strong passion, and commitment to science.
Apply here.
Career Accelerator Postdoctoral Fellowship
The Cancer Science Institute of Singapore (CSI) Career Accelerator Postdoctoral Fellowship invites outstanding applicants at the level of early-stage postdoctoral fellows. The awardees will be hosted within established research labs to develop their independent research programs and collaborate with other exceptional researchers. They will receive a competitive salary package with an annual research grant of up to SGD$25,000 per year and equipment grant of SGD$5,000. Access to state-of-the-art core facilities will be provided. The tenure is up to three years.
Applicants should fulfil the following criteria:
- Have completed a PhD within the last 18 months from time of submission of application, or to have received their PhDs by the time they commence the fellowship
- Work in any discipline of cancer research,
- Excellent track record of research accomplishments,
- Keen to embark on exciting and innovative projects in experimental and/or bioinformatics laboratories,
- Aspire to be leaders in biomedical research
Interested applicants should submit the following to csi_recruitment@nus.edu.sg or attach the following documents in your application. Please indicate “Application for CSI Career Accelerator Postdoctoral Fellowship” in the subject title. Only shortlisted candidates will be contacted.
- Cover letter,
- Curriculum Vitae (CV), including full publication list,
- Official transcript or Degree Certificate in English (PhD’s degree),
- Names and contact information (email and phone number) of 2 – 3 references (including PhD supervisor),
- Top 3 publications (in PDF), and
- Two-page research proposal (excluding references) summarising the background, significance, and aims and methods of the proposed research.
Apply via: https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=6350&company=nationalunP2
Research Scientist - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on organoid research?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Fellow to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537). The role will provide expertise in the establishment, genetic manipulation and maintenance of human and murine organoid cultures as well as design/ perform and analyse work within the project parameters.
Duties and Responsibilities
Research:
- Develop hypotheses and conceptualise, design and execute experiments to address the hypothesis
- To establish, engineer (e.g. by CRISPR) and maintain 3D organoid cultures from a variety of tissue systems
- To carry out molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations
- To organise, preserve and present the results of the experiments in a logical manner
- To properly and systematically record all experiments that have been assigned and their results
- To assist in supervising, training and guiding attachment/undergraduate students where required
Qualifications
ESSENTIAL qualifications include: (1) a PhD with 1-3 years’ relevant post-doctoral experience, (2) strong track record of research achievement evidenced by high-quality publications in a relevant field, (3) high-level experience in hands-on use of a wide range of relevant research methods with a focus on organoid work, (4) skills in working independently and creatively to solve experimental problems and (5) effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.
Preference will be given to candidates with: (1) Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy; (2) Previous experience with genetically engineered murine models, or (3) Knowledge of IRB, HBRA & IACUC regulations.
Apply here.
Research Assistant - Prof Chng Wee Joo
Duties and Responsibilities
a) Research:
- To carry out assigned experiments
- To conduct troubleshooting and refining of experimental procedures
- To organise, preserve and present the results of the experiments in a logical manner
- To properly and systematically record all experiments that have been assigned and their results
- To analyse and plan further experiments under guidance
- To keep abreast with the current research scene and to propose relevant techniques and latest technologies to answer hypothetical research questions
- To assist in supervising, training and guiding attachment/undergraduate students where required
b) Laboratory:
- To plan and ensure the needs and requirements of the team in terms of consumables
- To ensure that the lab is adequately stocked with clean glassware, minor equipment, chemicals, etc. required for experiments
- Responsible for the cleanliness and maintenance of equipment through regular checks
- Required to assemble reagents, chemicals and media that are needed for experiments
- To ensure that standard operating procedures and safety regulations are followed
- Responsible for the general cleanliness of the lab
c) Administrative duties:
- To plan and ensure that the overall research/lab administrative needs of the team are met, such as producing reports and preparing presentation slides
- Responsible for purchasing necessary equipment, chemicals, reagents as required by the lab or project
- Maintain a systematic and proper record of all purchases
- Liaising between the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies
d) Any other duties as required
Qualifications
- Background in NGS, molecular biology techniques, cell culture and mouse work is preferred.
- Committed, dedicated, diligent and motivated candidates with BSc or diploma with lab experience are welcome to apply.
- Willing to clock in extra hours (including coming back to the lab during the weekends) when there is an urgency to fulfil research deadlines.
- Willing to perform mouse work and handle patient samples.
- A team player
Knowledge of:
- Basic principles and practices in the fields of biology, physiology and/or chemistry.
- Principles, techniques and terminologies used in cancer biology.
- Scientific and cancer research methodologies.
- Principles, techniques and terminology used in the examination of clinical and animal samples.
- Scientific data analysis softwares such as Graphpad Prism.
- Quality assurance procedures applicable to a laboratory.
- General rules for safe exposure and handling of chemical
Apply here.
Senior Research Scientist - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on structural biology?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Senior Research Scientist to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
This position will be jointly under Dr. Tan Yong Zi, who is an expert on single-particle cryogenic electron microscopy (cryo-EM) (see https://www.tyzlab.com/). His lab is a core member of the Centre for BioImaging Sciences’ (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. The aim of this joint position is to use cryo-EM to help solve the structures of many exciting cancer complexes to help with potential drug development.
Duties and Responsibilities
The position exists to provide
- Optimisation and performance of structural biological related experiments and projects, particularly in the field of cryo-electron microscopy
- Sample Vitrification:
- Proteins will be produced separately, hence experience in protein production is not required, although favoured
- Candidate will be responsible for optimisation of the vitrification of grids
- Data Collection:
- Candidate will oversee collecting screening and high resolution cryo-EM data from the T12 and Krios
- Data analysis:
- Candidate will oversee processing the data and producing cryo-EM maps from high resolution Krios data collections
- Candidate will help setup the processing pipeline for CSI
- Education:
- Oversee training personnel from both CSI and Tan lab on cryo-EM
Qualifications
- PhD in cryo-EM or structural biology related field
- Firm understanding of the principles of cryo-EM
- Experience in single-particle cryo-EM sample vitrification, data collection and data processing
- Good publication record
- Excellent written and spoken English
- Friendly and personable
Please apply here.
Research Assistant - Prof Goh Boon Cher
The laboratory of Prof Goh Boon Cher at the Cancer Science Institute of Singapore is looking for a motivated candidate for a Research Assistant position. The established research group focuses on discovering novel cancer biomarkers to stratify high risk tumours for therapeutic interventions, by incorporating genomics, proteomics and high throughput technologies. Specifically, the successful candidate will be tasked to establish relevant tumour organoids/primary culture to improve understanding of tumour development and progression. The candidate will work alongside senior scientists to establish these cancer models. This project will cover a variety of experimental approaches, which include but not limited to molecular cloning, genome editing and bioimaging. As part of the lab responsibility, the candidate will also be involved in the biomarker screening workflow to support the ongoing clinical trials.
Duties And Responsibilities
- To perform experiments for the assigned projects.
- To maintain the general cleanliness of the lab and to assist in monitoring safety compliance at the bench.
- To help with assay development, drafting standard operating protocols and risk assessments.
- To support clinical studies by handling sample processing which include PBMC extraction from patient plasma, nucleic acid extraction, and biomarker detection.
- Assist in other research areas that may benefit from the candidate’s expertise when appropriate.
Qualifications
Essential:
- B.Sc or M.Sc on related degree (Life science, biomedical science, or biotechnology)
- Working experience in a biological research laboratory.
- Competent in mammalian cell culture.
- Fluent in spoken and written English.
- Meticulous and organized, with good attention to detail.
- Team and motivated worker.
- Able to take own initiative and work independently.
Non-Essential:
- Experience in 3D of primary human cultures.
- Experience in handling human biological samples (blood, tissue etc).
- Background knowledge in cancer biology and immunology.
- Competent in basic molecular technologies (molecular cloning and DNA/RNA work).
Interested applicants are encouraged to submit their applications with their curriculum vitae (2-page maximum, to include past working experience and educational record), cover letter (1-page), certificates of qualifications, and contacts of at least 2 professional references.
Please apply here.
Research Scientist - Prof Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on structural biology?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Senior Research Scientist to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
This position will be jointly under Dr. Tan Yong Zi, who is an expert on single-particle cryogenic electron microscopy (cryo-EM) (see https://www.tyzlab.com/). His lab is a core member of the Centre for BioImaging Sciences’ (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. The aim of this joint position is to use cryo-EM to help solve the structures of many exciting cancer complexes to help with potential drug development.
Duties and Responsibilities
The position exists to provide
- Optimisation and performance of structural biological related experiments and projects, particularly in the field of cryo-electron microscopy
- Sample Vitrification:
- Proteins will be produced separately, hence experience in protein production is not required, although favoured
- Candidate will be responsible for optimisation of the vitrification of grids
- Data Collection:
- Candidate will oversee collecting screening and high resolution cryo-EM data from the T12 and Krios
- Data analysis:
- Candidate will oversee processing the data and producing cryo-EM maps from high resolution Krios data collections
- Candidate will help setup the processing pipeline for CSI
- Education:
- Oversee training personnel from both CSI and Tan lab on cryo-EM
Qualifications
- PhD in cryo-EM or structural biology related field
- Firm understanding of the principles of cryo-EM
- Experience in single-particle cryo-EM sample vitrification, data collection and data processing
- Good publication record
- Excellent written and spoken English
- Friendly and personable
Please apply here.
Research Fellow (Bioinformatician) - A/Prof Polly Chen
A postdoctoral position is available immediately in A/Prof Polly Chen’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of A/P Polly Chen’s lab is on the transcriptome-wide identification of RNA changes (e.g., RNA editing, alterative splicing, altered protein-RNA interactions, etc) in tumors and functional investigation of these changes in cancer.
Duties and Responsibilities
Candidates should have strong background in bioinformatics, genomics/transcriptomics, computer science, statistics, or other related fields. Those who are interested in computational genomics and transcriptomics, particularly in analysis and integration of various genomics/transcriptomics data, are encouraged to apply. The successful candidate will analyze and integrate in-house NGS datasets (bulk and single-cell RNA-seq, spatial transcriptomics, DNA-seq, eCLIP-seq, MeDIP-seq, etc) and also utilize publicly available genomic/transriptomics/clinical data sets to identify novel biological biomarkers/patterns and regulatory mechanisms.
Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R, or other related programming knowledge), and excellent skills in handling genomic, transcriptomic and proteomic databases. Experience in analyzing RNA editing, alternative splicing, RNA binding sites using the bulk and single-cell RNA-seq, eCLIP-seq, spatial transcriptomic data is a plus.
Qualifications
- A PhD graduate with relevant experience in areas of computational biology/bioinformatics
- Extensive knowledge and experience in working with a variety of NGS datasets, pipeline development and algorithm development
- Strong publication track record, indicated by first author publications in high quality journals
- Strong analytical skills and programming skills
- Ability to write/contribute to research articles, grants and keep meticulous notes/proper scientific documentation
- Strong interpersonal, written and oral communication skills
- A strong team focus and ability to work independently
Please apply here.
Research Scientist - Prof Yoshiaki Ito
A postdoctoral position is available immediately for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer. The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, mentor students, and compete for fellowships.
Qualifications
- A Ph.D. in cancer biology or related area
- Experience with in vivo animal models, particularly mice and/or zebrafish
- Expertise in RNA biology (including but not limited to microRNAs) is preferred
- Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
- Any experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable
- A proven track record in the form of publications in top international English language journals
- Ability to communicate in written and spoken English
Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.
Please apply here.
Research Fellow/Senior Research Scientist (Bioinformatician, Cancer Science Institute) - Prof Chng Wee Joo
A postdoctoral/SRS position is available immediately in Prof Chng Wee Joo’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of the lab is on deciphering transcriptional and genomic abnormalities in the context of blood cancer, including epigenetic and superenhancer deregulation, using single cell sequencing amongst other genomics techniques.
Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis of single cell sequencing data, superenhancer and chromatic interaction data, and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (RNA-seq, small RNA-seq, microarray etc) data sets and also utilize publicly available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms.
Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R or other related programming knowledge), and excellent skills in handling Linux clusters and genomic databases. Experience in analyzing single cell and/or long-read sequencing data is ideal but not required.
Applications should send full curriculum vitae (not more than 3 pages) and the names, addresses and contact numbers of 3 professional references.
Apply here.
Research Fellow (Bioinformatician) - GeDaC
ROLES AND RESPONSIBILITIES
- Analyze and integrate various NGS data
- Build and reproduce pipelines to process all types of DNA and RNA sequencing data
- Maintain all source code within Git and Dockerize all pipeline components
- Liaise with the Scaling Unit to convert pipelines into scalable workflows
- To build and maintain general infrastructure components of the GeDaC cloud-based
platform (e.g. genomic databases) - Provide on-demand bioinformatics support for CSI investigators
- Any other services as requested by supervisors
REQUIREMENTS
- Masters or Ph.D. in genetics, genomics, bioinformatics, computational biology, or related fields with 2 years of working experience
- Solid foundation in biology and genomics
- Experience processing and analyzing high-throughput sequencing data
- Appreciable Python and/or R programming skills
PREFERENCES
- Experience analyzing legacy data types (microarrays, CGH arrays, etc.)
- Authorship on scientific publications
- Software development experience
- Experience with collaborative software development via github/gitlab
Apply here.
Research Fellow - Dr Dennis Kappei
We are seeking a highly motivated candidate as a research fellow in the Quantitative Proteomics Core in collaboration with the Kappei lab at the Cancer Science Institute of Singapore (CSI). Our team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study protein expression, protein interactions as well as post-translational modifications.
Proteins are the functional agents in cells, yet the systematic global characterization of their expression and spatial distribution has largely remained limited to the analysis of RNA as a proxy. To close this gap, we have recently expanded the Quantitative Proteomics Core to Clinical Proteomics applications with dedicated instruments including a timsTOF fleX mass spectrometer that allows for dual LC-MS/MS and MALDI imaging analysis. The research fellow will develop innovative workflows for both untargeted and targeted spatial protein imaging applied to the analysis of cancer tissues. We are offering a position in a stimulating, diverse and international research environment as well as the opportunity to gain expertise in a highly demanded technology using state-of-the-art instruments.
Requirements:
- PhD in life sciences, chemistry, medicine or related fields
- Strong background and working knowledge of basic molecular and biochemical techniques
- Excellent communication skills and good team spirit
- Ability to solve problems independently
- Penchant for method development
- Strong publication record
- Preference will be given to candidates with
- Experience with mass spectrometry (sample preparation and instrument operation/maintenance)
- Experience with image analysis and/or histology
Applications should include in a single PDF a 1-page cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Clinical Proteomics RF” to:
Dr. Dennis Kappei
Principal Investigator
CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Further information on the Cancer Science Institute of Singapore as well as working at CSI can be found on our website: www.csi.nus.edu.sg/web/careers/
Please apply here.
Research Fellow - Prof Goh Boon Cher
The position of Postdoctoral Research Fellow (RF) is available at the Cancer Science Institute of Singapore, National University of Singapore (CSI, NUS). The RF will be a member of Experimental Therapeutics Laboratory lead by Prof Boon-Cher Goh. The mission of the Experimental Therapeutics Laboratory is to identify new cancer biomarkers that could stratify high risk cancers for treatment interventions; and to develop novel therapeutic agents and delivery platforms to provide better treatment options for cancer patients. Nasopharyngeal carcinoma (NPC) is a solid tumour whose aetiology is closely linked to EBV infection. While Prof Goh’s clinical team are actively conducting clinical trials on the different therapeutic agents and treatment regimens for NPC; the lab team are focused on understanding cellular and molecular changes that occur in the malignant cells and within the tumour microenvironment that contribute to cancer progression and development of drug resistance. The role of the RF is to develop cancer vaccines and therapeutics specifically for the treatment of NPC. The position is available from October 2021 onwards for 3 years.
Roles and Responsibilities
- To examine the role of identified target molecules in NPC cell survival and function; corelating results with patient sample data and clinical information.
- To design immunogens and explore the different platforms for vaccine development.
- To design and conduct experiments to test vaccine prototypes in vitro and in mouse models, focusing on but not restricted to
- Their efficacies in stimulation the immune system and characterising the cellular and humoral immune responses
- Effects of vaccine on physiological functions, bone marrow function, thrombotic events etc
- Effects of vaccine in tumour-bearing mice
- To design and test novel therapeutic agents when appropriate.
- To help supervise RAs and mentor PhD students.
| Essential | Desirable |
| PhD in Biomedical Sciences, or related fields. | Experience in working with mouse models. |
| Strong background and working knowledge of molecular biology and cellular biology techniques. | Highly motivated and innovative to work independently, which strong troubleshooting abilities. |
| Firm understanding of cancer biology and immunology. | Able to work under pressure and deal with stress. |
| Strong mammalian cell tissue culture. | Preferable 1-2 years post graduate experience. |
| Proficiency in spoken and written English, able to contribute to the writing of grants and manuscripts. | Able to commence within 3 months of confirmation. |
| Able to communicate well and demonstrate teamwork. | Able to conduct literature reviews on the related research topics. |
Actions for interested applicants
Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, include education qualification, employment history, and research track record, (3) the contact details (telephone and emails) of 2 referees.
Please note that only short-listed candidates will be contacted.
Apply here.
Research Fellow (Bioinformatician) - GeDaC
ROLES AND RESPONSIBILITIES
- Build and reproduce pipelines to process all types of DNA and RNA sequencing data
- Perform quality control over all data being generated locally by the Genomics Bench
- Maintain all source code within Git and Dockerize all pipeline components
- Deploy pipelines on AWS and run on-demand
- Liaise with the Scaling Unit to convert pipelines into scalable workflows
- To build and maintain general infrastructure components of the GeDaC cloud-based platform (e.g. genomic databases)
- Provide on-demand bioinformatics support for CSI investigators
- Any other services as requested by supervisors
REQUIREMENTS
- Masters or Ph.D. in genetics, genomics, bioinformatics, computational biology, or related fields with 2 years of working experience
- Solid foundation in biology and genomics
- Experience processing and analyzing high-throughput sequencing data
- Appreciable Python and/or R programming skills
- Familiarity with cluster (including HPC) and/or cloud computing
- Excellent written and spoken English
PREFERENCES
- Experience analyzing legacy data types (microarrays, CGH arrays, etc.)
- Authorship on scientific publications
- Software development experience
- Experience with collaborative software development via github/gitlab
Apply here.
Research Fellow (Bioinformatician) - Dr Jason Pitt
The position of Postdoctoral Fellow (PDF) in computational cancer genomics is immediately available at The Cancer Science Institute of Singapore (The National University of Singapore). This PDF will lead a newly funded project in the laboratory of Dr. Jason Pitt that will explore how germline genetics and cell-of-origin contribute to genomic instability (GI) in cancer (see Pitt et al., 2018, Nat Comms; Pitt et al., 2018, Cancer Cell; Wang & Pitt et al., 2019, Int J Cancer). The acquisition of GI by malignant cells is critical to cancer development and progression. However, the magnitude and type of GI can vary widely across patients and cancer types. Delineating the underlying sources of GI will help identify novel therapeutic biomarkers (Pitt, Hoppe, & Jeyasekharan; PCT/SG2021/050105). The PDF will build upon our recently developed computational framework to derive dozens of GI scores and copy number signatures from tens of thousands of malignant samples. Using a multi-omic approach, these scores will be associated with clinical, genomic, and cell-type specific features. Candidate genes/variants will be investigated experimentally using CRISPR-mediated isogenic cell lines.
ROLES AND RESPONSIBILITIES
- Processing and management of public genomic data (WES, RNAseq, SNP array, etc.)
- Develop methods to estimate CN-based GI scores and signatures
- Use innovative approaches to associate inherited variation with GI patterns
- Determine the relationship between GI patterns and phenotypic features
- Lead manuscript writing and software documentation
- This position is for 2-3 years with the possibility of extension
REQUIREMENTS
- PhD in human genetics, genomics, bioinformatics, or related fields
- Firm understanding of human genetics and association studies
- Experience analyzing cancer genomics data
- Strong Python and/or R programming skills
- Penchant for statistical reasoning
- Strong publication record
- Excellent written and spoken English
PREFERENCES
- Familiarity with copy number and mutation signature analysis
- Experience using Amazon Web Services or high-performance computing
- Proficiency with Unix-based systems
- Experience with collaborative software development via github/gitlab
Apply here.
Research Assistant - Prof Lee Soo Chin
To provide support to the Principal Investigator in research projects, maintenance of laboratory inventory and administration. Research duties and responsibilities will include:
- Assisting to develop and carry out experiments and performing biological, hemotological, chemical, or physical analysis and determinations as tasked
- Organizing, preserving and presenting the results of the experiments in a logical manner to supervisors or in research meetings
- Assist in supervising, training and guiding attachment/undergraduate students where required
- Performing surgical procedures, geno-typing, post-mortem examinations, tissue collection activities, etc. involving laboratory animals, and when necessary to make injections and dissections
The Research Assistant is also required to cooperate in maintaining and planning for the needs of the lab team as well as to meet administrative duties that are assigned.
Honors degree (2nd upper class and above) in Life Sciences or similar field.
Candidates with 3-4 years of experience in a cancer biology laboratory and/or postgraduates will have an advantage.
Apply here.
Research Fellow (Bioinformatician) - Prof Ashok Venkitaraman
The position of Postdoctoral Fellow (PDF) — with an emphasis on computational cancer genomics — is immediately available at The Cancer Science Institute of Singapore (a part of The National University of Singapore). The postholder will work with the laboratories of Prof. Ashok Venkitaraman, Dr. Jason Pitt and Prof. Touati Benoukraf on a project studying the evolution of cancer genomes during early steps in carcinogenesis, with the long-term aim to develop better methods for early intervention.
This is an exciting opportunity to deploy expertise in computational biology in an active multidisciplinary environment, working closely with experimental cancer biologists to address major scientific problems.
The postholder will apply existing analytic pipelines and devise new algorithms to explore data derived from multiple DNA sequencing technologies (eg., Illumina & Nanopore) to resolve cancer genome evolution at the clonal level. S/he will also analyse complementary data from other technologies, ranging from single-cell RNAseq to chromatin immunoprecipitation to chromatin accessibility (ATAC-seq), using a variety of novel cellular models established in Prof. Venkitaraman’s laboratory. Experimental findings will be explored and validated using clinical genomic datasets.
A PhD in a relevant field, with a strong track record of achievement exemplified by publications, is important, as is the required expertise in computational biology listed below. Experience in the methods to be used in the project is desirable.
Requirements:
- PhD in human genetics, genomics, bioinformatics, computer science, or related fields
- Firm understanding of the principles of clonal evolution
- Experience analyzing DNA sequencing data
- Strong Python and/or R programming skills
- Proficient with standard statistical analyses
- Strong publication record
- Excellent written and spoken English
Preferences:
- Experience using Amazon Web Services
- Proficiency with Unix-based systems
- Experience with collaborative software development via github/gitlab
Please click here to apply.
Research Fellow – Prof Daniel G. Tenen
A postdoctoral position is available immediately for an extremely motivated Ph.D. or M.D with a strong background in molecular or cellular biology, biochemistry, or other related fields. The successful candidate will help to design and conduct experiments, analyse data, write papers and grants, including fellowships, and mentor and direct PhD students. Projects involve RNA biology with relevance to cancer, the oncofetal protein SALL4 in cancer, or both; a list of publications can be found at http://www.ncbi.nlm.nih.gov/pubmed/?term=Tenen+DG
Qualifications:
- A Ph.D. in cancer biology or related area, or M.D. with equivalent research experience
- Expertise in RNA biology preferred
- Strong background and working knowledge of basic molecular and cellular biology techniques, such as cell culture, cloning, real-time PCR and western blotting
- Experience with analyses of human clinical samples, RNA sequencing and other genomic techniques, and/or CRISPR genome editing is highly desirable
- A proven track record in the form of publications in top international English language journals
- Ability to communicate in written and spoken English
Applications should include curriculum vitae, publication list, and names and contact information (including telephone numbers) of 3 referees. Request that letters of recommendation be sent to daniel.tenen@nus.edu.sg (informal email recommendations are fine). Include a summary of your past research experience, a description of your long term plans, as well as ideas for at least two projects that you might want to work on in Dr. Tenen’s lab (half page each is fine, have fun with this!).
Please note that only shortlisted candidates will be contacted.
Research Fellow (Bioinformatician) – Dr Jason Pitt
BACKGROUND
The position of Postdoctoral Fellow with an emphasis on cancer genomics and bioinformatics is immediately available in the laboratory of Dr. Jason Pitt, which integrates data science and biological expertise to facilitate precision oncology. The Pitt Laboratory achieves this by developing cutting-edge software that allows rapid interrogation and interpretation of large genomic datasets. This position is connected to the Cancer Science Institute (CSI) Translational theme, which is building knowledge-bases and algorithms to recommend cancer treatments based on a patient’s genetic profile. This fellow will also work closely with clinician-scientist Dr. Anand Jeyasekharan to help facilitate molecular tumor boards at National University Hospital. An experienced genome analyst will have the unique opportunity to impact real-world precision oncology while developing skills in cloud computing, data science, and augmented intelligence.
RESPONSIBILITIES
Candidate will work with the CSI Translational Team to deliver the following:
- Aggregation and analysis of publicly available datasets
– Data wrangling of genomics and clinical datasets
– Processing and analysis of NGS data (e.g. DNA- & RNA-seq)
– Apply novel prediction algorithms over large-scale data - A knowledge graph for precision oncology
– Integrate drug, protein/gene, clinical trial, and genomics data
– Overlay analytics to discover novel biological and clinical insights
– Facilitate oncologist queries based on an entity of interest
REQUIREMENTS
- Ph.D. in bioinformatics, genomics, computer science, information systems, statistics, or related fields
- Experience analyzing data derived from high-throughput technologies
- Strong Python programming skills and proficiency with Unix-based systems
- Strong analytical and critical thinking skills
- Evidence of leading projects to completion
- Excellent written and spoken English
PREFERENCES
- Previous experience with cancer genomics data
- Familiarity with Amazon Web Services
- Database management experience (SQL, NoSQL, Elasticsearch, etc.)
- Experience with collaborative software development via github/gitlab
HOW TO APPLY
Applications should include full curriculum vitae, publication list (if applicable), and contact information for 2-3 referees. Please also include a single page cover letter summarizing your previous research, analytical/programmatic expertise, and why this position is of interest to you.
Apply via:
https://career44.sapsf.com/sfcareer/jobreqcareer?jobId=5336&company=nationalunP2
Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg
Senior Research Scientist – Prof. Ashok Venkitaraman
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Senior Research Scientist to join the team of our new Director, Prof. Ashok Venkitaraman, who has recently joined us from the University of Cambridge (see https://www.csi.nus.edu.sg/web/ashok-venkitaraman/). This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
ESSENTIAL qualifications include: (1) a PhD with 3 years’ relevant post-doctoral experience, (2) strong track record of research achievement evidenced by high-quality publications in a relevant field, (3) high-level experience in hands-on use of a wide range of relevant research methods, (4) skills in working independently and creatively to solve experimental problems and (5) effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.
Preference will be given to candidates with: (1) Previous experience in computational approaches to the analysis of (epi)genomic, transcriptomic or proteomic alterations in cancer or other diseases; (2) Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy, or (3) Previous experience with genetically engineered murine models.
More information on careers in NUS can be found at http://www.nus.edu.sg/careers/
Please submit applications including (1) a covering letter that explains why you are suited to this post, (2) a detailed CV, and (3) the contact details of 3 professional referees including your last position to:
Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment@nus.edu.sg
Website: www.csi.nus.edu.sg
Applications will be considered until the position is filled.
We will only contact candidates who are shortlisted.
Research Fellow (experimental work or bioinformatics) – Dr. Takaomi Sanda
A fulltime Research Fellow position will be available after January 2021.
The primary focus of our laboratory is to understand the mechanism of transformation by aberrant activation of oncogenic transcription factors in leukemia and other cancers. We are seeking highly motivated graduates. Candidates should have a PhD degree in molecular biology, cancer biology, medicine, bioinformatics, computational biology, computer science, or related fields.
- For experimental study position (wet lab work), candidates will work on molecular biological and sequencing experiments (ChIP-seq, RNA-seq, ATAC-seq, Hi-C, whole genome sequencing), and animal models to study cancer biology and normal development. Prior experiences in the use of mouse or zebrafish model as well as basic molecular biology techniques are required.
- For bioinformatics position (dry lab work), candidates will work on large scale genomic and transcriptomic data from next generation sequencing (ChIP-seq, RNA-seq, ATAC-seq, Hi-C, whole genome sequencing). Knowledge for optimization and statistical packages and programming (e.g., Python, Perl, C, C++, Java, R, or other related programming knowledge) are
The ability to work independently and design and interpret experiments is essential, together with excellent organizational skills and fluency in English. We are looking for a team- and goal-oriented personality who wants to work in a young and international team. Research Fellow will be encouraged to present data at internal and external meetings and publish in peer-reviewed journals.
Applications should include full curriculum vitae, publication list, information on years of experience in research work, and names and contact information (e-mail and telephone numbers) of 3 references. Inclusion of a summary of your research experience and a brief paragraph on why you want to join the Sanda lab is highly suggested.
Please note that only shortlisted candidates will be contacted.
Please send applications to:
Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
To apply for this position, please visit this link here.
Website: www.csi.nus.edu.sg
Research Fellow (Bioinformatician) – A/Prof Henry Yang & Dr Yvonne Tay
A postdoctoral position is available immediately in A/Prof Henry Yang and Dr Yvonne Tay’s groups for a highly motivated PhD graduate with experience in Bioinformatics (computational genomics). The focus of the lab is on deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Cell 2011; Chan et al, NAR 2018).
Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (RNA-seq, small RNA-seq, microarray etc) data sets and also utilize publicly available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms. Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R or other related programming knowledge), and excellent skills in handling Linux clusters and genomic databases. Experience in analyzing single cell and/or long-read sequencing data is ideal but not required.
Applications should send full curriculum vitae (not more than 3 pages) and the names, addresses and contact numbers of 3 professional references to csiyangh@nus.edu.sg and yvonnetay@nus.edu.sg with the subject title – ‘Application for HY/YT postdoc position’.
Recruitment Brochure
