2022

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022)

November 28, 2022

Adult T-cell leukemia/lymphoma (ATL) is a genetically complex hematological malignancy derived from mature T cells.

Read More
Nov 28, 2022 C K Sangamitha 0 comments
An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022)

November 24, 2022

Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), combination treatment chosen for an individual patient is empirical, and response rates remain poor in individuals with chemotherapy-resistant disease.

Read More
Nov 24, 2022 C K Sangamitha 0 comments
Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022)

November 24, 2022

Intercellular mitochondria transfer is a biological phenomenon implicated in diverse biological processes.

Read More
Nov 24, 2022 C K Sangamitha 0 comments
Congratulations to Prof. Toshio Suda on Clinching the 2022 ISEH Outstanding Mentor Award!

November 23, 2022

The International Society for Experimental Hematology  (ISEH) aims to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of young investigators and organization of scientific meetings.

Read More
Nov 23, 2022 C K Sangamitha 0 comments
Dr Spencer Yang Chong Wins the ASH Abstract Achievement Award

November 23, 2022

Congratulations to Dr. Spencer Yang Chong on receiving the 2022 ASH Abstract Achievement Award, adding on to previous years' wins!

Read More
Nov 23, 2022 C K Sangamitha 0 comments
CSI Singapore Congratulates Winners at the 9th NCIS Annual Research Meeting (NCAM 2022)

August 30, 2022

Hosted by the National University Cancer Institute, Singapore (NCIS), the 9th NCIS Annual Research Meeting (NCAM) had its meeting between 19th to 20th August 2022.

Read More
Aug 30, 2022 C K Sangamitha 0 comments
A Genomic-augmented Multivariate Prognostic Model for the Survival of Natural-killer/T-cell Lymphoma Patients from an International Cohort (Am J Hematol, Jun 2022)

August 15, 2022

With lowering costs of sequencing and genetic profiling techniques, genetic drivers can now be detected readily in tumors but current prognostic models for Natural-killer/T cell lymphoma (NKTCL) have yet to fully leverage on them for prognosticating patients.

Read More
Aug 15, 2022 C K Sangamitha 0 comments
A Degradative to Secretory Autophagy Switch Mediates Mitochondria Clearance in the Absence of the mATG8-conjugation Machinery (Nat Commun., Jun 2022)

August 15, 2022

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria.

Read More
Aug 15, 2022 C K Sangamitha 0 comments
SETDB1 Acts as a Topological Accessory to Cohesin via an H3K9me3-independent, Genomic Shunt for Regulating Cell Fates (Nucleic Acids Res, Jul 2022)

August 10, 2022

SETDB1 is a key regulator of lineage-specific genes and endogenous retroviral elements (ERVs) through its deposition of repressive H3K9me3 mark.

Read More
Aug 10, 2022 C K Sangamitha 0 comments
Congratulations to the Graduating Class of 2022!

August 10, 2022

CSI Singapore would like to extend its heartiest congratulations to the graduates of the PhD Graduate Program in Cancer Biology!

Read More
Aug 10, 2022 C K Sangamitha 0 comments
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities (Gut, Jul 2022)

August 5, 2022

According to GLOBOCAN, gastric cancer (GC) is a significant cause of cancer mortality worldwide, with over 700,000 deaths attributable to it annually. Mesenchymal-subtype gastric cancer (Mes-GC) is a particularly aggressive subtype associated with poor clinical prognosis and chemoresistance. However, few effective treatment options are currently available. Existing regimens consist of “one-size-fits-all” approaches such as surgery […]

Read More
Aug 05, 2022 Kimberly Ho 0 comments
[Review] Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis (J Clin Oncol, June 2022)

July 25, 2022

The peritoneum is a common site of metastasis in advanced gastric cancer (GC). Diagnostic laparoscopy is now routinely performed as part of disease staging, leading to an earlier diagnosis of synchronous peritoneal metastasis (PM).

Read More
Jul 25, 2022 C K Sangamitha 0 comments
Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid (ACS Nano., June 2022)

July 25, 2022

Bioorthogonal catalysis (BC) generates chemical reactions not present in normal physiology for the purpose of disease treatment. Because BC catalytically produces the desired therapy only at the site of disease, it holds the promise of site-specific treatment with little or no systemic exposure or side effects.

Read More
Jul 25, 2022 C K Sangamitha 0 comments
Identification of Mechanism of Cancer-cell-specific Reactivation of hTERT Offers Therapeutic Opportunities for Blocking Telomerase Specifically in Human Colorectal Cancer (Nucleic Acids Res., June 2022)

July 22, 2022

Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is reactivated, in majority of human cancers, remain unknown.

Read More
Jul 22, 2022 C K Sangamitha 0 comments
Pan-cancer Pervasive Upregulation of 3’UTR Splicing Drives Tumorigenesis (Nat. Cell Biol., May 22)

July 7, 2022

Most mammalian genes generate messenger RNAs (mRNAs) that consist of central protein-coding regions flanked by variable untranslated regions (UTRs). These UTRs, while not directly involved in protein production, nevertheless harbour many regulatory sequences and structures, and play important roles in post-transcriptional regulation, ensuring correct gene expression and function. Changes to these UTRs can be pathogenic, […]

Read More
Jul 07, 2022 Kimberly Ho 0 comments