Latest Happenings

CSI Research Fellow Receives International Myeloma Society (IMS) and Paula and Rodger Riney Foundation Career Development Award

April 7, 2021

Congratulations to Dr. Teoh Phaik Ju, Research Fellow from Prof. Chng Wee Joo’s lab, who has recently been awarded the prestigious International Myeloma Society (IMS) and Paula and Rodger Riney Foundation Career Development Award for her outstanding research proposal.

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Apr 07, 2021 Celine Tam 0 comments
Researchers Unravel Novel Insights on Hematopoietic Stem Cell (HSC) Maintenance and its Mechanism Under Thrombopoietin (Thpo) Deficiency

April 6, 2021

In this study, a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), the International Research Center for Medical Sciences (IRCMS) at the Kumamoto University and the Tokyo Women’s Medical University (TWMU) investigated the maintenance of HSCs in quiescence as well as its association with cytokine Thrombopoietin (Thpo).

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Apr 06, 2021 Celine Tam 0 comments
NUS Medicine Awards 2020

March 19, 2021

Dr. Chong Shu Yun Phyllis and Dr. Teoh Phaik Ju were awarded by A/Prof. Kevin Tan, Vice-Dean of Graduate Studies Congratulations to Dr. Teoh Phaik Ju and Dr. Chong Shu Yun Phyllis, who were honoured for their research achievements at the NUS Medicine Awards 2020 Ceremony. The award ceremony recognises and celebrates the success and […]

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Mar 19, 2021 Celine Tam 0 comments
Epigenetics in Cancer Symposium 2021

March 12, 2021

The Epigenetics in Cancer Symposium 2021 has concluded successfully! Jointly organized by the Cancer Science Institute of Singapore, NUS and the Université de Paris, the symposium drew an overwhelming turnout of 442 participants hailing from 32 countries. This inaugural symposium boasted an impressive line-up of speakers, including keynote speaker, Dr. Geneviève Almouzni from the Institut Curie, Paris.

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Mar 12, 2021 Celine Tam 0 comments
“3G” Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy. (Cancer Res, Feb 2021)

March 12, 2021

Gastric cancer (GC) cases are often diagnosed at an advanced stage with poor prognosis. Platinum-based chemotherapy has been internationally accepted as first-line therapy for inoperable or metastatic GC. To achieve greater benefits, selection of patients eligible for this treatment is critical. Although gene expression profiling has been widely used as a genomic classifier to identify molecular subtypes of GC and to stratify patients for different chemotherapy regimens, its prediction accuracy can be improved.

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Mar 12, 2021 Celine Tam 0 comments
H3K27me3-rich Genomic Regions Can Function as Silencers to Repress Gene Expression via Chromatin Interactions. (Nat Commun, Jan 2021)

March 12, 2021

The mechanisms underlying gene repression and silencers are poorly understood. Here we investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters of H3K27me3 peaks, may be used to identify silencers that can regulate gene expression via proximity or looping. We find that H3K27me3-rich regions are associated with chromatin interactions and interact preferentially with each other.

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Mar 12, 2021 Celine Tam 0 comments
MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. (Oncogene, Feb 2021)

March 12, 2021

Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcome of patients with advanced tumors especially de-differentiated liposarcoma and uterine leiomyosarcoma remains unsatisfactory, despite intensive treatment regimens including maximal surgical resection, radiation, and chemotherapy. MAP kinase-interacting serine/threonine-protein kinase 1 and 2 (MNK1/2) have been shown to contribute to oncogenic translation via phosphorylation of eukaryotic translation initiation factor 4E (eIF4E).

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Mar 12, 2021 Celine Tam 0 comments
Short H2A histone variants are expressed in cancer. (Nat Commun, Jan 2021)

February 4, 2021

Short H2A (sH2A) histone variants are primarily expressed in the testes of placental mammals. Their incorporation into chromatin is associated with nucleosome destabilization and modulation of alternate splicing. Here, we show that sH2As innately possess features similar to recurrent oncohistone mutations associated with nucleosome instability.

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Feb 04, 2021 Celine Tam 0 comments
Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age. (Trends Pharmacol Sci, Jan 2021)

February 4, 2021

Deregulation of MYC is among the most frequent oncogenic drivers of cancer. Developing targeted therapies against MYC is, therefore, one of the most critical unmet needs of cancer therapy. Unfortunately, MYC has been labelled as undruggable due to the lack of success in developing clinically relevant MYC-targeted therapies. Synthetic lethality is a promising approach that targets MYC-dependent vulnerabilities in cancer.

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Feb 04, 2021 Celine Tam 0 comments
ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. (Nat Commun, Jan 2021)

February 4, 2021

CCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin-chromatin interactions, yet the mechanism regulating its binding to chromatin is unknown. We demonstrate that zinc finger protein 143 (ZNF143) is a key regulator for CTCF-bound promoter-enhancer loops. In the murine genome, a large percentage of CTCF and ZNF143 DNA binding motifs are distributed 37 bp apart in the convergent orientation.

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Feb 04, 2021 Celine Tam 0 comments
Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. (Gut, Dec 2020)

December 28, 2020

Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. Results revealed that IQGAP3 is a major regulator of stomach epithelial tissue homoeostasis and repair. The upregulation of IQGAP3 in gastric cancer suggests that IQGAP3 plays an important role in cancer cell proliferation.

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Dec 28, 2020 Celine Tam 0 comments
The double-edged sword of H19 lncRNA: Insights into cancer therapy (Cancer Lett, Nov 2020)

December 28, 2020

H19 long non-coding RNA (lncRNA) has many functions in cancer. Some studies have reported that H19 acts as an oncogene and is involved in cancer progression by activating epithelial-mesenchymal transition (EMT), the cell cycle and angiogenesis via mechanisms like microRNA (miRNA) sponging - the binding to and inhibition of miRNA activity. This makes H19 lncRNA a potential target for cancer therapeutics. However, several conflicting studies have also found that H19 suppresses tumour development. In this review, we shed light on the possible reasons for these conflicting findings.

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Dec 28, 2020 Celine Tam 0 comments
EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. (Nat Commun, Nov 2020)

December 28, 2020

HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired resistance remains a significant challenge in the clinic. Here, we show that the protein phosphatase 2A (PP2A) regulatory subunit PPP2R2B is a crucial determinant of anti-HER2 response.

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Dec 28, 2020 Celine Tam 0 comments
ADARs, RNA editing and more in hematological malignancies. (Leukemia, Nov 2020)

November 19, 2020

Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA (ADARs). In this review, we will highlight the functions of ADARs and their involvements in cancer, specifically in hematological malignancies. RNA editing-independent function of cellular processes by ADARs and the potential of developing novel therapeutic approaches revolving RNA editing will also be discussed.

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Nov 19, 2020 Celine Tam 0 comments
Systematic analysis of intronic microRNAs reveals cooperativity within the multi-component FTX locus to promote colon cancer development. (Cancer Res, Nov 2020)

November 19, 2020

Approximately half of all microRNA reside within intronic regions and are often co-transcribed with their host genes. However, most studies of intronic microRNA focus on individual microRNA, while conversely most studies of protein-coding and non-coding genes frequently ignore any intron-derived microRNA. We hypothesize that the individual components of such multi-genic loci may play cooperative or competing roles in driving disease progression and that examining the combinatorial effect of these components would uncover deeper insights into their functional importance.

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Nov 19, 2020 Celine Tam 0 comments
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. (Blood, Oct 2020)

November 19, 2020

Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal and differentiation, are tightly regulated by the epigenetic machineries. Using conditional gene-knockout models, we demonstrated a critical requirement of lysine acetyltransferase 5 (Kat5, also known as Tip60) for murine HSC maintenance in both the embryonic and adult stages, which depends on its acetyltransferase activity.

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Nov 19, 2020 Celine Tam 0 comments
Virtual Frontiers in Cancer Science 2020 Conference

November 18, 2020

The Frontiers in Cancer Science (FCS) 2020 conference concluded successfully last week. This year’s conference was hosted virtually from 2nd – 6th November 2020 on ZOOM.  Returning for its 12th year, FCS 2020 is proudly and jointly organised by nine major research institutes in Singapore – Cancer Science Institute of Singapore, Duke-NUS Medical School, Genome […]

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Nov 18, 2020 Celine Tam 0 comments
Virtual RNA Biology Symposium 2020

November 18, 2020

The virtual 6th RNA Biology Symposium 2020 was successfully held on 1st October – 2nd October. Jointly organised for the first time by five different institutions (RNA Biology Centre NUS-CSI, Duke-NUS Medical School, Skin Research Institute-A*STAR, School of Biological Sciences-NTU and AMR-Singapore-MIT Alliance for Research and Technology), the symposium attracted a total of 427 registrants, […]

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Nov 18, 2020 Celine Tam 0 comments
CSI Singapore Welcomes New Director, Prof. Ashok Venkitaraman

October 30, 2020

We are pleased to announce the appointment of Prof.  Ashok Venkitaraman as the new Director of CSI Singapore as of 1st November, 2020. He has been appointed distinguished professor in the Department of Medicine with effect from 16 November 2020, and will also lead a programme at the Agency for Science, Technology and Research (A*STAR).

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Oct 30, 2020 Celine Tam 0 comments
Team CSI Joins the Race to Save Lives and Advocate Cancer Cause!

October 12, 2020

The Singtel-Singapore Cancer Society Race Against Cancer (RAC) was a 9-day event (19th – 27th September) where participants can run anywhere in Singapore or around the world by using a GPS-enabled app. Organised by the Singapore Cancer Society, proceeds raised from RAC 2020 will support cancer treatment subsidies, welfare assistance, cancer rehabilitation, hospice care, cancer screenings, research, public education and cancer support group initiatives.

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Oct 12, 2020 Celine Tam 0 comments