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Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination. (BMJ Open Gastreoentero, Aug 2020)

October 6, 2020

Differentiating between malignant and normal cells within tissue samples is vital for molecular profiling of cancer using advances in genomics and transcriptomics. Cell-surface markers of tumour-normal discrimination have additional value in terms of translatability to diagnostic and therapeutic strategies. In gastric cancer (GC), previous studies have identified individual genes or proteins that are upregulated in cancer.

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Oct 06, 2020 Celine Tam 0 comments
Core transcriptional regulatory circuitries in cancer. (Oncogene, Sep 2020)

October 6, 2020

Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward transcriptional loops to establish and reinforce the cell-type-specific gene-expression program; the ensemble of core TFs and their regulatory loops constitutes core transcriptional regulatory circuitry (CRC).

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Oct 06, 2020 Celine Tam 0 comments
Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. (Cell Mol Life Sci, Aug 2020)

October 6, 2020

RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported aberrant adenosine-to-inosine RNA editing is implicated in cancers. Until now, very few functionally important protein-recoding editing targets have been discovered. Here, we investigated the role of a recently discovered protein-recoding editing target COPA (coatomer subunit ?) in hepatocellular carcinoma (HCC).

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Oct 06, 2020 Celine Tam 0 comments
September is Blood Cancer Awareness Month: 5 Questions with A/Prof Takaomi Sanda

September 1, 2020

1) How did you embark on your journey as a researcher? Several factors have affected my career decision to embark on my journey as a researcher in hematology and oncology. The first factor was my first patient I saw as a medical doctor on the first day of my residency training in 2000. She was […]

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Sep 01, 2020 Celine Tam 0 comments
Congratulations to Prof. Chng Wee Joo for being the first Asian recipient of the prestigious 2020 Brian G.M Durie Outstanding Achievement Award!

August 27, 2020

  Warmest congratulations to CSI Deputy Director and Senior Principal Investigator, Prof. Chng Wee Joo for being awarded the 2020 Brian G.M Durie Outstanding Achievement Award! Prof. Chng is the first Asian to receive this prestigious award, which aims to honour outstanding individual who has demonstrated excellence in multiple myeloma research and whose work has […]

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Aug 27, 2020 Celine Tam 0 comments
CSI Singapore Clinches Multiple Awards at NCAM 2020 Digital Meeting

August 6, 2020

The 7th NCSIS Annual Research Meeting (NCAM) 2020 recently concluded its first digital meeting. Co-organised by National University Cancer Institute (NCIS) and CSI Singapore, the NCAM 2020 Digital Meeting hosted a total of 727 attendees from 58 institutions. The theme for this year’s meeting is ‘Cancer Care: From Bench to Bedside’. Held from 22 July – […]

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Aug 06, 2020 Celine Tam 0 comments
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis (J Hepatol, Jul 2020)

August 6, 2020

RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported aberrant adenosine-to-inosine RNA editing is implicated in cancers. Until now, very few functionally important protein-recoding editing targets have been discovered. Here, we investigated the role of a recently discovered protein-recoding editing target COPA (coatomer subunit ?) in hepatocellular carcinoma (HCC).

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Aug 06, 2020 Celine Tam 0 comments
TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines (Gastroenterology, Jun 2020)

August 6, 2020

Yan-Yi Jiang 1, Yuan Jiang 2, Chun-Quan Li 3, Ying Zhang 4, Pushkar Dakle 4, Harvinder Kaur 4, Jian-Wen Deng 4, Ruby Yu-Tong Lin 4, Lin Han 4, Jian-Jun Xie 5, Yiwu Yan 6, Ngan Doan 7, Yueyuan Zheng 8, Anand Mayakonda 4, Masaharu Hazawa 9, Liang Xu 4, YanYu Li 3, Luay Aswad 10, Maya Jeitany 4, Deepika Kanojia 4, Xin-Yuan Guan 11, Jonathan W Said 7, Wei Yang 6, Melissa J Fullwood 12, De-Chen Lin 13, H Phillip Koeffler 14 Author Information 1 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA; Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department […]

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Aug 06, 2020 Celine Tam 0 comments
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential (Haematologica, Jun 2020)

August 6, 2020

Aled O’Neill 1, Desmond Chin 1, Darren Tan 1, A Qilah Banu Bte Abdul Majeed 1, Ayako Nakamura-Ishizu 2, Toshio Suda 3 Author Information 1 Cancer Science Institute, National University of Singapore, Singapore. 2 Cancer Science Institute, National University of Singapore & Kumamoto University, Japan. 3 Cancer Science Institute, National University of Singapore & Kumamoto University, Japan sudato@sc.itc.keio.ac.jp. Abstract: Thrombopoietin (THPO) has long been known to […]

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Aug 06, 2020 Celine Tam 0 comments
Novel Digital Medicine Platform Offers New Hope for Lymphoma Patients

July 25, 2020

Researchers from Cancer Science Institute of Singapore (CSI Singapore) and National University Cancer Institute of Singapore (NCIS) recently harnessed the Quadratic Phenotypic Optimisation Platform (QPOP), an AI-driven digital medicine platform, to revolutionize the treatment for lymphoma. Developed by a research team led by CSI Singapore Principal Investigator, Associate Professor Edward Chow, QPOP leverages artificial intelligence […]

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Jul 25, 2020 Celine Tam 0 comments
Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance. (Blood, Jun 2020)

July 8, 2020

Akihiko Numata 1, Hui Si Kwok 1, Qi-Ling Zhou 1, Jia Li 1, Roberto Tirado-Magallanes 2, Vladimir Espinosa Angarcia 3, Rebecca Louise Hannah 4, Jihye Park 5, Chelsia Qiuxia Wang 6, Vaidehi Krishnan 3, Deepa Rajagopalan 3, Yangzhou Zhang 1, Siqin Zhou 7, Robert Welner 8, Motomi Osato 2, Sudhakar Jha 1, Stefan K Bohlander 9, Bertie Göttgens 10, Henry Yang 3, Touati Benoukraf 11, John W Lough 12, Deepak Bararia 1, Daniel G Tenen 3 Author Information 1Cancer Science Institute of Singapore, Singapore, Singapore. 2National University of Singapore, Singapore, Singapore. 3Cancer Science Institute of Singapore, Singapore, Singapore. 4University of […]

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Jul 08, 2020 Celine Tam 0 comments
Suppression of Adenosine-To-Inosine (A-to-I) RNA Editome by Death Associated Protein 3 (DAP3) Promotes Cancer Progression. (Sci Adv, Jun 2020)

July 8, 2020

Jian Han 1, Omer An 1, HuiQi Hong 1 2, Tim Hon Man Chan 1, Yangyang Song 1, Haoqing Shen 1, Sze Jing Tang 1, Jaymie Siqi Lin 1, Vanessa Hui En Ng 1, Daryl Jin Tai Tay 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1, Hui Qing Tan 2, Henry Yang 1, Leilei Chen 1 3 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, […]

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Jul 08, 2020 Celine Tam 0 comments
Hematopoietic Stem Cells Acquire Survival Advantage by Loss of RUNX1 Methylation Identified in Familial Leukemia. (Blood, Jun 2020)

July 8, 2020

Takayoshi Matsumura 1, Ayako Nakamura-Ishizu 1, Siva Sai Naga Anurag Muddineni 1, Darren Qiancheng Tan 1, Chelsia Qiuxia Wang 2, Kenji Tokunaga 3, Roberto Tirado-Magallanes 1, Stephanie Sian 1, Touati Benoukraf 4, Tsukasa Okuda 5, Norio Asou 6, Masao Matsuoka 7, Motomi Osato 1, Toshio Suda 1 Author Information 1National University of Singapore, Singapore, Singapore. 2Cancer Science Institute of Singapore, NUS, Singapore, Singapore. 3Kumamoto University School of Medicine, Kumamoto, Japan. 4Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada. 5Kyoto Prefectural […]

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Jul 08, 2020 Celine Tam 0 comments
Congratulations to Prof. Toshio Suda for being awarded the 2020 E. Donnall Thomas Lecture and Prize!

July 2, 2020

CSI Singapore is pleased to announce that Senior Principal Investigator, Prof. Toshio Suda, has been awarded the 2020 E. Donnall Thomas Lecture and Prize for his outstanding contributions to the field of stem cell research. Prof. Suda will present his lecture at the 62nd ASH Annual Meeting and Exposition. Established in 1992, this lectureship and […]

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Jul 02, 2020 Celine Tam 0 comments
Oncorequisite Role of an Aldehyde Dehydrogenase in the Pathogenesis of T-cell Acute Lymphoblastic Leukemia. (Haematologica, May 2020)

June 15, 2020

Chujing Zhang 1, Stella Amanda 1, Cheng Wang 2, Tze King Tan 1, Muhammad Zulfaqar Ali 1, Wei Zhong Leong 1, Ley Moy Ng 1, Shojiro Kitajima 3, Zhenhua Li 4, Allen Eng Juh Yeoh 5, Shi Hao Tan 1, Takaomi Sanda 6 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Anatomy, National University of Singapore, Singapore. 3Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan. 4Department of Paediatrics, National University of Singapore, […]

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Jun 15, 2020 Celine Tam 0 comments
CSI NGS Portal: An Online Platform for Automated NGS Data Analysis and Sharing. (Int J Mol Sci, May 2020)

June 12, 2020

Omer An 1, Kar-Tong Tan 1, Ying Li 1, Jia Li 1, Chan-Shuo Wu 1, Bin Zhang 1, Leilei Chen 1 2, Henry Yang 1 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore. Abstract Next-generation sequencing (NGS) has been a widely-used technology in biomedical research for understanding the role […]

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Jun 12, 2020 Celine Tam 0 comments
Congratulations to Dr. Takaomi Sanda on his promotion to Associate Professor!

May 14, 2020

CSI Singapore is proud to announce the promotion of Dr. Takaomi Sanda to Associate Professor. Dr. Sanda joined CSI Singapore in 2013 as a Principal Investigator. Since then, he has achieved an impressive track record in his research studies, which mostly focus on T-cell acute lymphoblastic leukemia (T-ALL) and other lymphoid malignancies. Please join us […]

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May 14, 2020 Celine Tam 0 comments
IDentif.AI: Artificial Intelligence Pinpoints Remdesivir in Combination with Ritonavir and Lopinavir as an Optimal Regimen Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

May 12, 2020

CSI Principal Investigator, A/Professor Edward Chow was recently involved in an impactful study led by Professor Dean Ho. The team reported the use of Identif.AI, a platform that rapidly optimizes infectious disease (ID) combination therapy design using artificial intelligence. In the study, IDentif.AI was implemented on a 12-drug candidate therapy search set representing over 530,000 […]

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May 12, 2020 Celine Tam 0 comments
Recent Study by CSI Researchers Holds Promise for Improved Therapeutic Treatment of Tumours with Mutated p53

April 30, 2020

Tumours with missense mutant p53 (mutp53) acquire additional oncogenic gain-of-function (GOF) based on their unique structural modifications. These GOF DNA binding domain (DBD) mutations lose their tumour-suppressive ability, yet favour cancer cell proliferation, migration, metastases as well as rendering resistant to chemotherapies. In this interesting study, researchers from CSI Singapore delved into the oncogenic GOF […]

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Apr 30, 2020 Celine Tam 0 comments
NanoVar: accurate characterization of patients’ genomic structural variants using low-depth nanopore sequencing. (Genome Biol, Mar 2020)

April 22, 2020

Tham CY1, Tirado-Magallanes R1, Goh Y1, Fullwood MJ1,2, Koh BTH3, Wang W3,4, Ng CH5, Chng WJ1,5,6, Thiery A7, Tenen DG1,8, Benoukraf T1,9. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore, 117599, Singapore. 2 School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore. 3 Department of Orthopedic Surgery, National University Health […]

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Apr 22, 2020 Celine Tam 0 comments