Latest Happenings

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. (Theranostics, Feb 2020)

April 22, 2020

Chin TM1,2,3, Boopathy GTK1,4, Man EPS1, Clohessy JG5, Csizmadia E5, Quinlan MP6, Putti T2, Wan SC1, Xie C1, Ali A1, Wai FC1, Ong YS4, Goh BC1,2, Settleman J6,7, Hong W4, Levantini E5,8, Tenen DG1,5. Author Information 1. Cancer Science Institute, National University of Singapore, 14 Medical Drive, Singapore 117599. 2. National University Health System, 5 Lower Kent Ridge Road, Singapore 119074. 3. Parkway Cancer Centre, Gleneagles Hospital. 6A Napier Road, Singapore […]

Read More
Apr 22, 2020 Celine Tam 0 comments
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. (Nat Commun, Mar 2020)

April 22, 2020

Kong LR1,2, Mohamed Salleh NAB3, Ong RW4, Tan TZ3, Syn NL3,5, Goh RM5, Fhu CW3, Tan DSW6,7,8, Iyer NG3,9,10, Kannan S11, Verma CS11,12,13, Lim YC14, Soo R5, Ho J5, Huang Y5, Lim JSJ3,5, Yan BJ14, Nga ME14, Lim SG15,16, Koeffler HP3,5,15,17, Lee SC3,5, Kappei D3, Hung HT4, Goh BC18,19,20. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiklr@nus.edu.sg. 2 Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. […]

Read More
Apr 22, 2020 Celine Tam 0 comments
CSI Singapore Welcomes Interim Director

April 6, 2020

CSI Singapore is pleased to announce the appointment of Prof. Barry Halliwell as interim Director. His appointment will begin from 1 April to 18 October 2020, until Prof. Ashok Venkitaraman officially comes on board. Prof. Halliwell is a Senior Advisor, Academic Appointments and Research Excellence, at the Office of the Senior Deputy President and Provost […]

Read More
Apr 06, 2020 Celine Tam 0 comments
A Unique CDK4/6 Inhibitor: Current and Future Therapeutic Strategies of Abemaciclib. (Pharmacol Res, Feb 2020)

March 4, 2020

Chong QY1, Kok ZH1, Bui NL1, Xiang X2, Li-Ann Wong A3, Peng Yong W3, Sethi G4, Lobie PE5, Wang L6, Goh BC7. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, China. 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Health […]

Read More
Mar 04, 2020 Celine Tam 0 comments
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity. (Cell Rep, Feb 2020)

March 4, 2020

Endoh M1, Baba M2, Endoh T3, Hirayama A4, Nakamura-Ishizu A5, Umemoto T6, Hashimoto M6, Nagashima K7, Soga T4, Lang M8, Schmidt LS9, Linehan WM8, Suda T10. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore; International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan; Institute of Molecular Embryology and Genetics (IMEG), […]

Read More
Mar 04, 2020 Celine Tam 0 comments
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development. (Nat Commun, Feb 2020)

March 4, 2020

Tang SJ1, Shen H1,2, An O1, Hong H1,3, Li J1, Song Y1, Han J1, Tay DJT1, Ng VHE1, Bellido Molias F1, Leong KW1, Pitcheshwar P1,2, Yang H1, Chen L4,5. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2 Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117594, Singapore. 3 Department of Physiology, Yong Loo Lin School […]

Read More
Mar 04, 2020 Celine Tam 0 comments
Dr. Takaomi Sanda Awarded the Yong Loo Lin School of Medicine Research Excellence Award

February 11, 2020

Dr. Takaomi Sanda, Principal Investigator at CSI Singapore, was recently awarded the Yong Loo Lin School of Medicine Research Excellence Award for AY2018/2019. This award honours and celebrates faculty members who have demonstrated excellent achievements as researchers. Dr. Sanda’s exemplary dedication to furthering cancer research has contributed to a better understanding of T-cell acute lymphoblastic […]

Read More
Feb 11, 2020 Celine Tam 0 comments
Feed-forward Regulatory Loop Driven by IRF4 and NF-kB in Adult T-cell Leukemia/Lymphoma. (Blood, Jan 2020)

February 10, 2020

Wong R1, Tan TK2, Amanda S3, Ngoc PCT4, Leong WZ5, Tan SH6, Asamitsu K7, Hibi Y8, Ueda R9, Okamoto T8, Ishida T10, Iida S11, Sanda T6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore. 3Cancer Science Institute of Singapore, Singapore, Singapore. 4Cancer Science Institute of Singapore, National University of Singapore, Lund, Sweden. 5National […]

Read More
Feb 10, 2020 Celine Tam 0 comments
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia. (Gut, Jan 2020)

February 10, 2020

Krishnan V1,2, Lim DXE#1, Hoang PM#1, Srivastava S#3,4, Matsuo J1, Huang KK2, Zhu F4, Ho KY4,5, So JBY6,7, Khor C8, Tsao S9, Teh M3, Fock KM10, Ang TL10, Jeyasekharan AD1, Tan P2,7, Yeoh KG11,5,7, Ito Y12,7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 169857, Singapore. 3Department of Pathology, National University of Singapore, Singapore […]

Read More
Feb 10, 2020 Celine Tam 0 comments
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells. (Mol Cells, Jan 2020)

February 10, 2020

Chuang LSH1, Osato M1, Ito Y1. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Abstract: The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell […]

Read More
Feb 10, 2020 Celine Tam 0 comments
Researchers from CSI Singapore & ASLAN Pharmaceuticals Make Headway in the Treatment of Acute Myeloid Leukemia.

January 22, 2020

Acute Myeloid Leukemia (AML) is a common and aggressive blood cancer and has a relatively poor overall survival rate. Characterized by an overproduction of immature white blood cells, AML has limited treatment options, with chemotherapy being the main therapeutic approach that is currently available. However, chemotherapy is non-selective, which kills fast-dividing leukemic cells as well […]

Read More
Jan 22, 2020 Celine Tam 0 comments
Frontiers in Cancer Science 2019

December 5, 2019

The 11th Frontiers in Cancer Science (FCS) conference took place at The Academia @ SGH from 4 to 6 November 2019. Jointly organised by seven major research institutes in Singapore – Cancer Science Institute of Singapore (CSI Singapore), Duke-NUS Medical School (Duke-NUS), Genome Institute of Singapore (GIS), Institute of Molecular and Cell Biology (IMCB), Lee […]

Read More
Dec 05, 2019 Celine Tam 0 comments
TFregulomeR reveals transcription factors’ context-specific features and functions. (Nucleic Acids Res, Nov 2019)

December 4, 2019

Lin QXX1, Thieffry D2, Jha S1,3, Benoukraf T1,4. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Computational Systems Biology Team, Institut de Biologie de l’École Normale Supérieure (IBENS), CNRS, INSERM, École Normale Supérieure, PSL Research University, Paris 75005, France. 3Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore. 4Discipline of Genetics, Faculty […]

Read More
Dec 04, 2019 Celine Tam 0 comments
Nanodiamond-Mediated Delivery of a G9a Inhibitor for Hepatocellular Carcinoma Therapy. (ACS Appl Mater Interfaces, Nov 2019)

December 2, 2019

Gu M1,2, Toh TB3, Hooi L2, Lim JJ2, Zhang X2,4, Chow EK1,2,3. Author Information 1Department of Pharmacology, Yong Loo Lin School of Medicine , National University of Singapore , 117600 , Singapore. 2Cancer Science Institute of Singapore , National University of Singapore , 117599 , Singapore. 3The N.1 Institute for Health , National University of Singapore , 117456 , Singapore. […]

Read More
Dec 02, 2019 Celine Tam 0 comments
ASLAN003, a Potent Dihydroorotate Dehydrogenase Inhibitor for Differentiation of Acute Myeloid Leukemia. (Haematologica, Nov 2019)

December 2, 2019

Zhou J1, Quah JY1, Ng Y1, Chooi JY2, Toh SH1, Lin B3, Tan TZ1, Hosoi H1, Osato M4, Seet Q5, Ooi AGL5, Lindmark B5, McHale M5, Chng WJ6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Republic of Singapore. 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore. 3Department of Hematology-Oncology, National University Cancer Institute, Republic of Singapore. 4Cancer Science Institute […]

Read More
Dec 02, 2019 Celine Tam 0 comments
DNA Epigenetic Signature Predictive of Benefit from Neoadjuvant Chemotherapy in Oesophageal Adenocarcinoma: Results from the MRC OE02 Trial. (Eur J Cancer, Oct 2019)

December 2, 2019

Sundar R1, Ng A2, Zouridis H3, Padmanabhan N4, Sheng T4, Zhang S4, Lee MH4, Ooi WF4, Qamra A4, Inam I5, Hewitt LC6, So JB7, Koh V8, Nankivell MG9, Langley RE9, Allum WH10, Cunningham D11, Rozen SG12, Yong WP8, Grabsch HI13, Tan P14. Author Information 1Department of Haematology-Oncology, National University Health System, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2Cancer and […]

Read More
Dec 02, 2019 Celine Tam 0 comments
CSI Research Scientist Wins ASH Abstract Achievement Award

December 2, 2019

  Congratulations to Dr. Zhou Jianbiao, Senior Research Scientist from Prof. Chng Wee Joo’s team, who has been awarded the American Society of Hematology (ASH) Abstract Achievement Award for his abstract titled “Super-Enhancer Profiling Identifies Novel Oncogenes and Therapeutic Targets in Multiple Myeloma”. He will be presenting his work at the 61st ASH Annual Meeting and […]

Read More
Dec 02, 2019 Celine Tam 0 comments
CSI Singapore Welcomes New Director, Professor Ashok Venkitaraman

November 20, 2019

The Cancer Science Institute of Singapore (CSI Singapore) is pleased to announce the appointment of Professor Ashok Venkitaraman as the new Director of CSI Singapore. Prof Venkitaraman will take over the reins from CSI Singapore’s Founding Director, Professor Daniel G Tenen after a period of transition from his current appointments at the University of Cambridge, […]

Read More
Nov 20, 2019 Celine Tam 0 comments
c-Met activation leads to the establishment of a TGFB-receptor regulatory network in bladder cancer progression. (Nat Commun., Sep 2019)

November 7, 2019

Sim WJ1, Iyengar PV2,3, Lama D4, Lui SKL2, Ng HC1, Haviv-Shapira L5, Domany E5, Kappei D2,6, Tan TZ2, Saie A6,7, Jaynes PW2, Verma CS4,8,9, Kumar AP2,10,11,12, Rouanne M13,14, Ha HK15, Radulescu C16, Ten Dijke P3, Eichhorn PJA17,18,19,20, Thiery JP21,22,23. Author Information 1Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 3Department of Cell and Chemical Biology and Oncode Institute, Leiden University […]

Read More
Nov 07, 2019 Celine Tam 0 comments
RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling. (Cancer Res, Sep 2019)

November 7, 2019

Loh XY1, Sun QY1, Ding LW2, Mayakonda A1, Venkatachalam N1, Yeo MS1, Silva TC3, Xiao JF1, B Doan N4, W Said J4, Ran XB1, Zhou SQ1, Dakle P1, Shyamsunder P1, Koh AP1, Huang RY5, P Berman B3, Tan SY6, Yang H1, Lin DC7, Koeffler HP7. Author Information <sup1Cancer Science Institute of Singapore, National University of Singapore. 2Cancer Science Institute of Singapore, National University of Singapore zipy001@gmail.com. 3Cedars-Sinai Medical Center, Los Angeles, CA, USA., Center for […]

Read More
Nov 07, 2019 Celine Tam 0 comments