Latest Happenings

A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types. (RNA Biol, Oct 2019)

November 7, 2019

Zhang B1, Babu KR1, Lim CY1, Kwok ZH1, Li J1, Zhou S1, Yang H1,2, Tay Y1,2. Author Information 1Cancer Science Institute of Singapore, National University of Singapore , Singapore , Singapore. 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore. Abstract: RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and […]

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Nov 07, 2019 Celine Tam 0 comments
CSI Graduate Recruitment 2019

October 30, 2019

On 8th October 2019, CSI Singapore hosted the Graduate Recruitment, which was attended by participants from varied backgrounds, ranging from undergraduate students and graduates from NTU and NUS to research staff from National Cancer Centre Singapore (NCCS) and National University Cancer Institute (NCIS). The event served as an excellent platform for participants to gain insights […]

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Oct 30, 2019 Celine Tam 0 comments
CSI Research Fellows Awarded at the 17th International Myeloma Workshop (IMW)

October 9, 2019

  Congratulations to Dr. Teoh Phaik Ju and Dr. Chooi Jing Yuan, research fellows from Prof. Chng Wee Joo’s group who recently won awards to attend and present their research at the 17th International Myeloma Workshop (IMW) which took place from 12-15 September 2019. Held at the Hynes Convention Center in Boston MA, USA, IMW 2019 […]

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Oct 09, 2019 Celine Tam 0 comments
c-Met activation leads to the establishment of a TGFB-receptor regulatory network in bladder cancer progression. (Nat Commun, Sep 2019)

September 30, 2019

Sim WJ1, Iyengar PV2,3, Lama D4, Lui SKL2, Ng HC1, Haviv-Shapira L5, Domany E5, Kappei D2,6, Tan TZ2, Saie A6,7, Jaynes PW2, Verma CS4,8,9, Kumar AP2,10,11,12, Rouanne M13,14, Ha HK15, Radulescu C16, Ten Dijke P3, Eichhorn PJA17,18,19,20, Thiery JP21,22,23. Author Information 1Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 3Department of Cell and Chemical Biology and Oncode Institute, Leiden […]

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Sep 30, 2019 Celine Tam 0 comments
CAV1 – GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer. (Theranostics, Aug 2019)

September 30, 2019

Ali A1, Levantini E2,3,4, Fhu CW1, Teo JT1, Clohessy JG3,5, Goggi JL6, Wu CS1, Chen L1, Chin TM1,7, Tenen DG1,2. Author Information 1Cancer Science Institute Singapore, National University of Singapore, MD6, #12-01, 14 Medical Drive, Singapore 117599. 2Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. 3Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 4Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy. […]

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Sep 30, 2019 Celine Tam 0 comments
Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/B-catenin-driven hepatocellular carcinoma. (J Hepatol, Sep 2019)

September 30, 2019

Toh TB1, Lim JJ2, Hooi L2, Rashid MBMA3, Chow EK4. Author Information 1The N.1 Institute for Health (N.1), National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address: lsittb@nus.edu.sg. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, […]

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Sep 30, 2019 Celine Tam 0 comments
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. (Gastroenterology, Aug 2019)

September 30, 2019

Tan JL1, Li F2, Yeo JZ1, Yong KJ2, Bassal MA3, Ng GH4, Lee MY4, Leong CY5, Tan HK2, Wu CS2, Liu BH2, Chan TH2, Tan ZH2, Chan YS4, Wang S4, Lim ZH4, Toh TB2, Hooi L2, Low KN5, Ma S4, Kong NR6, Stein AJ6, Wu Y7, Thangavelu MT4, Suzuki A8, Periyasamy G4, Asara JM9, Dan YY10, Bonney GK11, Chow EK12, Lu GD13, Ng HH4, Kanagasundaram Y5, Ng SB5, Tam WL14, Tenen DG15, Chai L16. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore; Genome […]

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Sep 30, 2019 Celine Tam 0 comments
CSI Deputy Director, Prof. Goh Boon Cher, Receives National Outstanding Clinician Scientist Award

September 17, 2019

  CSI extends our heartiest congratulations to our Deputy Director, Prof. Goh Boon Cher, for being awarded the National Outstanding Clinician Scientist Award at this year’s National Medical Excellence Awards (NMEA) ceremony. The NMEA is a national-level award to recognize the efforts of clinicians, clinician-scientists and other healthcare professionals for their contributions. Conferred by the […]

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Sep 17, 2019 Celine Tam 0 comments
IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma. (Haematologica, Aug 2019)

August 31, 2019

Teoh PJ1, Chung TH2, Chng PYZ2, Toh SHM2, Chng WJ3. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore; mdctpju@nus.edu.sg. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Abstract: 1q21 amplification (1q21(amp)) is an important prognostic marker in multiple myeloma. […]

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Aug 31, 2019 Celine Tam 0 comments
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. (Gut, Aug 2019)

August 31, 2019

Chen L#1, Huang M#2, Plummer J#3, Pan J#4, Jiang YY#5, Yang Q1, Silva TC3, Gull N3, Chen S3, Ding LW5, An O5, Yang H5, Cheng Y6, Said JW7, Doan N7, Dinjens WN8, Waters KM9, Tuli R10, Gayther SA3, Klempner SJ11,12, Berman BP3, Meltzer SJ6, Lin DC13, Koeffler HP1,5. Author Information 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. 2School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China dchlin11@gmail.com huangml@suda.edu.cn. 3Center for Bioinformatics and Functional […]

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Aug 31, 2019 Celine Tam 0 comments
Interleukin-6 promotes a STAT3-PRL3 feedforward loop via SHP2 repression in Multiple Myeloma. (Cancer Res, Jul 2019)

August 31, 2019

Chong PSY1, Zhou J2, Lim JSL1, Hee YT3, Chooi JY2, Chung TH2, Tan TZ4, Zeng Q5, Waller DD6, Sebag M6, Chng WJ7. Author Information 1CSI Singapore, Cancer Science Institute of Singapore. 2Cancer Science Institute of Singapore, National University of Singapore. 3Nanyang Technological University. 4CSI, Cancer Science Institute, NUS. 5Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research). 6McGill University. 7Hematology-Oncology, National […]

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Aug 31, 2019 Celine Tam 0 comments
CSI Staff and Students Bag Multiple Awards at NCAM 2019

August 29, 2019

Congratulations to our PhD graduate students and staff for receiving several awards during the 6th NCIS Annual Research Meeting (NCAM) 2019. Co-organised by the National University Cancer Institute, Singapore (NCIS) and CSI Singapore, the annual conference was held on 2nd August 2019 at National University Health System, Singapore. The meeting is a full-day program attended […]

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Aug 29, 2019 Celine Tam 0 comments
A Warm Welcome to Our New PhD Students!

August 14, 2019

New semester, new beginnings! – CSI Singapore warmly welcomed 8 new PhD students who joined our graduate program in Cancer Biology on 1st August 2019. The PhD program, offered by CSI Singapore, is designed to support graduate students working to advance discoveries in cancer research. These students will undergo a rigorous five-year academic and research program. […]

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Aug 14, 2019 Celine Tam 0 comments
Congratulations to the Class of 2019!

August 14, 2019

Congratulations to the graduates of the PhD Graduate Program in Cancer Biology! On 23rd July 2019, CSI Singapore organized a Graduate Tea Party in honour of the Class of 2019. After years of dedication and hard work, our graduates and their supervisors gathered to celebrate this significant milestone, which marks the end of their PhD journey […]

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Aug 14, 2019 Celine Tam 0 comments
SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition. (Sci Rep, Jun 2019)

August 2, 2019

Sundararajan V1, Tan M1, Tan TZ1, Ye J1, Thiery JP2,3,4,5, Huang RY6,7,8,9. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive, MD6 #12-01, 117599, Singapore, Singapore. 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, MD7, #02-03, Singapore, 117597, Singapore. 3Guangzhou Institute of Biomedicine […]

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Aug 02, 2019 Celine Tam 0 comments
Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. (J Hematol Oncol, Jul 2019)

August 2, 2019

Jia Y1,2, Chng WJ1,3,4, Zhou J5,6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Centre for Translational Medicine, Singapore, 117599, Republic of Singapore. 2Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang, China. 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, […]

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Aug 02, 2019 Celine Tam 0 comments
Inflated performance measures in enhancer-promoter interaction-prediction methods. (Nat Genet, Jul 2019)

August 2, 2019

Cao F1, Fullwood MJ2,3,4. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg. 3School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg. 44Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. mfullwood@ntu.edu.sg.   […]

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Aug 02, 2019 Celine Tam 0 comments
A Heartfelt Thank You to Our Donor, Mr Sim Chee Meng

July 8, 2019

CSI Singapore would like to extend a heartfelt thank you to our donor, Mr Sim Chee Meng for his giving. The institute is devoted to fostering ground-breaking research and developing cancer therapies. Over the years, the generous support of our donors has been fundamental in supporting the institute in its mission to advance knowledge, foster […]

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Jul 08, 2019 Celine Tam 0 comments
CSI Student Receives Gold Award at the Singapore Science and Engineering Fair (SSEF) 2019 Ceremony

June 28, 2019

Congratulations to Shamill Amedot Udonwa, attachment student from Prof. Chng Wee Joo’s laboratory, who clinched the Gold Award at the Singapore Science and Engineering Fair (SSEF) 2019, held from 6th-7th March 2019 at the Community Auditorium, Our Tampines Hub. Organized by the Ministry of Education (MOE), the Agency for Science, Technology and Research (A*STAR) and […]

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Jun 28, 2019 Celine Tam 0 comments
DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells. (Nucleic Acids Res, Jun 2019)

June 28, 2019

Tan HK1,2, Wu CS1, Li J1,3, Tan ZH1, Hoffman JR4, Fry CJ4, Yang H1, Di Ruscio A5,6, Tenen DG1,6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599. 2National University of Singapore Graduate School for Integrative Sciences and Engineering, 21 Lower Kent Ridge, Singapore 119077. 3Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College […]

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Jun 28, 2019 Celine Tam 0 comments