Stories

The double-edged sword of H19 lncRNA: Insights into cancer therapy (Cancer Lett, Nov 2020)

December 28, 2020

H19 long non-coding RNA (lncRNA) has many functions in cancer. Some studies have reported that H19 acts as an oncogene and is involved in cancer progression by activating epithelial-mesenchymal transition (EMT), the cell cycle and angiogenesis via mechanisms like microRNA (miRNA) sponging - the binding to and inhibition of miRNA activity. This makes H19 lncRNA a potential target for cancer therapeutics. However, several conflicting studies have also found that H19 suppresses tumour development. In this review, we shed light on the possible reasons for these conflicting findings.

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Dec 28, 2020 Celine Tam 0 comments
EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. (Nat Commun, Nov 2020)

December 28, 2020

HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired resistance remains a significant challenge in the clinic. Here, we show that the protein phosphatase 2A (PP2A) regulatory subunit PPP2R2B is a crucial determinant of anti-HER2 response.

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Dec 28, 2020 Celine Tam 0 comments
ADARs, RNA editing and more in hematological malignancies. (Leukemia, Nov 2020)

November 19, 2020

Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA (ADARs). In this review, we will highlight the functions of ADARs and their involvements in cancer, specifically in hematological malignancies. RNA editing-independent function of cellular processes by ADARs and the potential of developing novel therapeutic approaches revolving RNA editing will also be discussed.

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Nov 19, 2020 Celine Tam 0 comments
Systematic analysis of intronic microRNAs reveals cooperativity within the multi-component FTX locus to promote colon cancer development. (Cancer Res, Nov 2020)

November 19, 2020

Approximately half of all microRNA reside within intronic regions and are often co-transcribed with their host genes. However, most studies of intronic microRNA focus on individual microRNA, while conversely most studies of protein-coding and non-coding genes frequently ignore any intron-derived microRNA. We hypothesize that the individual components of such multi-genic loci may play cooperative or competing roles in driving disease progression and that examining the combinatorial effect of these components would uncover deeper insights into their functional importance.

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Nov 19, 2020 Celine Tam 0 comments
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. (Blood, Oct 2020)

November 19, 2020

Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal and differentiation, are tightly regulated by the epigenetic machineries. Using conditional gene-knockout models, we demonstrated a critical requirement of lysine acetyltransferase 5 (Kat5, also known as Tip60) for murine HSC maintenance in both the embryonic and adult stages, which depends on its acetyltransferase activity.

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Nov 19, 2020 Celine Tam 0 comments
Virtual Frontiers in Cancer Science 2020 Conference

November 18, 2020

The Frontiers in Cancer Science (FCS) 2020 conference concluded successfully last week. This year’s conference was hosted virtually from 2nd – 6th November 2020 on ZOOM.  Returning for its 12th year, FCS 2020 is proudly and jointly organised by nine major research institutes in Singapore – Cancer Science Institute of Singapore, Duke-NUS Medical School, Genome […]

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Nov 18, 2020 Celine Tam 0 comments
Virtual RNA Biology Symposium 2020

November 18, 2020

The virtual 6th RNA Biology Symposium 2020 was successfully held on 1st October – 2nd October. Jointly organised for the first time by five different institutions (RNA Biology Centre NUS-CSI, Duke-NUS Medical School, Skin Research Institute-A*STAR, School of Biological Sciences-NTU and AMR-Singapore-MIT Alliance for Research and Technology), the symposium attracted a total of 427 registrants, […]

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Nov 18, 2020 Celine Tam 0 comments
CSI Singapore Welcomes New Director, Prof. Ashok Venkitaraman

October 30, 2020

We are pleased to announce the appointment of Prof.  Ashok Venkitaraman as the new Director of CSI Singapore as of 1st November, 2020. He has been appointed distinguished professor in the Department of Medicine with effect from 16 November 2020, and will also lead a programme at the Agency for Science, Technology and Research (A*STAR).

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Oct 30, 2020 Celine Tam 0 comments
Team CSI Joins the Race to Save Lives and Advocate Cancer Cause!

October 12, 2020

The Singtel-Singapore Cancer Society Race Against Cancer (RAC) was a 9-day event (19th – 27th September) where participants can run anywhere in Singapore or around the world by using a GPS-enabled app. Organised by the Singapore Cancer Society, proceeds raised from RAC 2020 will support cancer treatment subsidies, welfare assistance, cancer rehabilitation, hospice care, cancer screenings, research, public education and cancer support group initiatives.

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Oct 12, 2020 Celine Tam 0 comments
Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination. (BMJ Open Gastreoentero, Aug 2020)

October 6, 2020

Differentiating between malignant and normal cells within tissue samples is vital for molecular profiling of cancer using advances in genomics and transcriptomics. Cell-surface markers of tumour-normal discrimination have additional value in terms of translatability to diagnostic and therapeutic strategies. In gastric cancer (GC), previous studies have identified individual genes or proteins that are upregulated in cancer.

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Oct 06, 2020 Celine Tam 0 comments
Core transcriptional regulatory circuitries in cancer. (Oncogene, Sep 2020)

October 6, 2020

Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward transcriptional loops to establish and reinforce the cell-type-specific gene-expression program; the ensemble of core TFs and their regulatory loops constitutes core transcriptional regulatory circuitry (CRC).

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Oct 06, 2020 Celine Tam 0 comments
Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. (Cell Mol Life Sci, Aug 2020)

October 6, 2020

RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported aberrant adenosine-to-inosine RNA editing is implicated in cancers. Until now, very few functionally important protein-recoding editing targets have been discovered. Here, we investigated the role of a recently discovered protein-recoding editing target COPA (coatomer subunit ?) in hepatocellular carcinoma (HCC).

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Oct 06, 2020 Celine Tam 0 comments
September is Blood Cancer Awareness Month: 5 Questions with A/Prof Takaomi Sanda

September 1, 2020

1) How did you embark on your journey as a researcher? Several factors have affected my career decision to embark on my journey as a researcher in hematology and oncology. The first factor was my first patient I saw as a medical doctor on the first day of my residency training in 2000. She was […]

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Sep 01, 2020 Celine Tam 0 comments
Congratulations to Prof. Chng Wee Joo for being the first Asian recipient of the prestigious 2020 Brian G.M Durie Outstanding Achievement Award!

August 27, 2020

  Warmest congratulations to CSI Deputy Director and Senior Principal Investigator, Prof. Chng Wee Joo for being awarded the 2020 Brian G.M Durie Outstanding Achievement Award! Prof. Chng is the first Asian to receive this prestigious award, which aims to honour outstanding individual who has demonstrated excellence in multiple myeloma research and whose work has […]

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Aug 27, 2020 Celine Tam 0 comments
CSI Singapore Clinches Multiple Awards at NCAM 2020 Digital Meeting

August 6, 2020

The 7th NCSIS Annual Research Meeting (NCAM) 2020 recently concluded its first digital meeting. Co-organised by National University Cancer Institute (NCIS) and CSI Singapore, the NCAM 2020 Digital Meeting hosted a total of 727 attendees from 58 institutions. The theme for this year’s meeting is ‘Cancer Care: From Bench to Bedside’. Held from 22 July – […]

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Aug 06, 2020 Celine Tam 0 comments
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis (J Hepatol, Jul 2020)

August 6, 2020

RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported aberrant adenosine-to-inosine RNA editing is implicated in cancers. Until now, very few functionally important protein-recoding editing targets have been discovered. Here, we investigated the role of a recently discovered protein-recoding editing target COPA (coatomer subunit ?) in hepatocellular carcinoma (HCC).

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Aug 06, 2020 Celine Tam 0 comments
TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines (Gastroenterology, Jun 2020)

August 6, 2020

Yan-Yi Jiang 1, Yuan Jiang 2, Chun-Quan Li 3, Ying Zhang 4, Pushkar Dakle 4, Harvinder Kaur 4, Jian-Wen Deng 4, Ruby Yu-Tong Lin 4, Lin Han 4, Jian-Jun Xie 5, Yiwu Yan 6, Ngan Doan 7, Yueyuan Zheng 8, Anand Mayakonda 4, Masaharu Hazawa 9, Liang Xu 4, YanYu Li 3, Luay Aswad 10, Maya Jeitany 4, Deepika Kanojia 4, Xin-Yuan Guan 11, Jonathan W Said 7, Wei Yang 6, Melissa J Fullwood 12, De-Chen Lin 13, H Phillip Koeffler 14 Author Information 1 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA; Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department […]

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Aug 06, 2020 Celine Tam 0 comments
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential (Haematologica, Jun 2020)

August 6, 2020

Aled O’Neill 1, Desmond Chin 1, Darren Tan 1, A Qilah Banu Bte Abdul Majeed 1, Ayako Nakamura-Ishizu 2, Toshio Suda 3 Author Information 1 Cancer Science Institute, National University of Singapore, Singapore. 2 Cancer Science Institute, National University of Singapore & Kumamoto University, Japan. 3 Cancer Science Institute, National University of Singapore & Kumamoto University, Japan sudato@sc.itc.keio.ac.jp. Abstract: Thrombopoietin (THPO) has long been known to […]

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Aug 06, 2020 Celine Tam 0 comments
Novel Digital Medicine Platform Offers New Hope for Lymphoma Patients

July 25, 2020

Researchers from Cancer Science Institute of Singapore (CSI Singapore) and National University Cancer Institute of Singapore (NCIS) recently harnessed the Quadratic Phenotypic Optimisation Platform (QPOP), an AI-driven digital medicine platform, to revolutionize the treatment for lymphoma. Developed by a research team led by CSI Singapore Principal Investigator, Associate Professor Edward Chow, QPOP leverages artificial intelligence […]

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Jul 25, 2020 Celine Tam 0 comments
Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance. (Blood, Jun 2020)

July 8, 2020

Akihiko Numata 1, Hui Si Kwok 1, Qi-Ling Zhou 1, Jia Li 1, Roberto Tirado-Magallanes 2, Vladimir Espinosa Angarcia 3, Rebecca Louise Hannah 4, Jihye Park 5, Chelsia Qiuxia Wang 6, Vaidehi Krishnan 3, Deepa Rajagopalan 3, Yangzhou Zhang 1, Siqin Zhou 7, Robert Welner 8, Motomi Osato 2, Sudhakar Jha 1, Stefan K Bohlander 9, Bertie Göttgens 10, Henry Yang 3, Touati Benoukraf 11, John W Lough 12, Deepak Bararia 1, Daniel G Tenen 3 Author Information 1Cancer Science Institute of Singapore, Singapore, Singapore. 2National University of Singapore, Singapore, Singapore. 3Cancer Science Institute of Singapore, Singapore, Singapore. 4University of […]

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Jul 08, 2020 Celine Tam 0 comments