Stories

Suppression of Adenosine-To-Inosine (A-to-I) RNA Editome by Death Associated Protein 3 (DAP3) Promotes Cancer Progression. (Sci Adv, Jun 2020)

July 8, 2020

Jian Han 1, Omer An 1, HuiQi Hong 1 2, Tim Hon Man Chan 1, Yangyang Song 1, Haoqing Shen 1, Sze Jing Tang 1, Jaymie Siqi Lin 1, Vanessa Hui En Ng 1, Daryl Jin Tai Tay 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1, Hui Qing Tan 2, Henry Yang 1, Leilei Chen 1 3 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, […]

Read More
Jul 08, 2020 Celine Tam 0 comments
Hematopoietic Stem Cells Acquire Survival Advantage by Loss of RUNX1 Methylation Identified in Familial Leukemia. (Blood, Jun 2020)

July 8, 2020

Takayoshi Matsumura 1, Ayako Nakamura-Ishizu 1, Siva Sai Naga Anurag Muddineni 1, Darren Qiancheng Tan 1, Chelsia Qiuxia Wang 2, Kenji Tokunaga 3, Roberto Tirado-Magallanes 1, Stephanie Sian 1, Touati Benoukraf 4, Tsukasa Okuda 5, Norio Asou 6, Masao Matsuoka 7, Motomi Osato 1, Toshio Suda 1 Author Information 1National University of Singapore, Singapore, Singapore. 2Cancer Science Institute of Singapore, NUS, Singapore, Singapore. 3Kumamoto University School of Medicine, Kumamoto, Japan. 4Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada. 5Kyoto Prefectural […]

Read More
Jul 08, 2020 Celine Tam 0 comments
Congratulations to Prof. Toshio Suda for being awarded the 2020 E. Donnall Thomas Lecture and Prize!

July 2, 2020

CSI Singapore is pleased to announce that Senior Principal Investigator, Prof. Toshio Suda, has been awarded the 2020 E. Donnall Thomas Lecture and Prize for his outstanding contributions to the field of stem cell research. Prof. Suda will present his lecture at the 62nd ASH Annual Meeting and Exposition. Established in 1992, this lectureship and […]

Read More
Jul 02, 2020 Celine Tam 0 comments
Oncorequisite Role of an Aldehyde Dehydrogenase in the Pathogenesis of T-cell Acute Lymphoblastic Leukemia. (Haematologica, May 2020)

June 15, 2020

Chujing Zhang 1, Stella Amanda 1, Cheng Wang 2, Tze King Tan 1, Muhammad Zulfaqar Ali 1, Wei Zhong Leong 1, Ley Moy Ng 1, Shojiro Kitajima 3, Zhenhua Li 4, Allen Eng Juh Yeoh 5, Shi Hao Tan 1, Takaomi Sanda 6 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Anatomy, National University of Singapore, Singapore. 3Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan. 4Department of Paediatrics, National University of Singapore, […]

Read More
Jun 15, 2020 Celine Tam 0 comments
CSI NGS Portal: An Online Platform for Automated NGS Data Analysis and Sharing. (Int J Mol Sci, May 2020)

June 12, 2020

Omer An 1, Kar-Tong Tan 1, Ying Li 1, Jia Li 1, Chan-Shuo Wu 1, Bin Zhang 1, Leilei Chen 1 2, Henry Yang 1 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore. Abstract Next-generation sequencing (NGS) has been a widely-used technology in biomedical research for understanding the role […]

Read More
Jun 12, 2020 Celine Tam 0 comments
Congratulations to Dr. Takaomi Sanda on his promotion to Associate Professor!

May 14, 2020

CSI Singapore is proud to announce the promotion of Dr. Takaomi Sanda to Associate Professor. Dr. Sanda joined CSI Singapore in 2013 as a Principal Investigator. Since then, he has achieved an impressive track record in his research studies, which mostly focus on T-cell acute lymphoblastic leukemia (T-ALL) and other lymphoid malignancies. Please join us […]

Read More
May 14, 2020 Celine Tam 0 comments
IDentif.AI: Artificial Intelligence Pinpoints Remdesivir in Combination with Ritonavir and Lopinavir as an Optimal Regimen Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

May 12, 2020

CSI Principal Investigator, A/Professor Edward Chow was recently involved in an impactful study led by Professor Dean Ho. The team reported the use of Identif.AI, a platform that rapidly optimizes infectious disease (ID) combination therapy design using artificial intelligence. In the study, IDentif.AI was implemented on a 12-drug candidate therapy search set representing over 530,000 […]

Read More
May 12, 2020 Celine Tam 0 comments
Recent Study by CSI Researchers Holds Promise for Improved Therapeutic Treatment of Tumours with Mutated p53

April 30, 2020

Tumours with missense mutant p53 (mutp53) acquire additional oncogenic gain-of-function (GOF) based on their unique structural modifications. These GOF DNA binding domain (DBD) mutations lose their tumour-suppressive ability, yet favour cancer cell proliferation, migration, metastases as well as rendering resistant to chemotherapies. In this interesting study, researchers from CSI Singapore delved into the oncogenic GOF […]

Read More
Apr 30, 2020 Celine Tam 0 comments
NanoVar: accurate characterization of patients’ genomic structural variants using low-depth nanopore sequencing. (Genome Biol, Mar 2020)

April 22, 2020

Tham CY1, Tirado-Magallanes R1, Goh Y1, Fullwood MJ1,2, Koh BTH3, Wang W3,4, Ng CH5, Chng WJ1,5,6, Thiery A7, Tenen DG1,8, Benoukraf T1,9. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore, 117599, Singapore. 2 School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore. 3 Department of Orthopedic Surgery, National University Health […]

Read More
Apr 22, 2020 Celine Tam 0 comments
Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. (Theranostics, Feb 2020)

April 22, 2020

Chin TM1,2,3, Boopathy GTK1,4, Man EPS1, Clohessy JG5, Csizmadia E5, Quinlan MP6, Putti T2, Wan SC1, Xie C1, Ali A1, Wai FC1, Ong YS4, Goh BC1,2, Settleman J6,7, Hong W4, Levantini E5,8, Tenen DG1,5. Author Information 1. Cancer Science Institute, National University of Singapore, 14 Medical Drive, Singapore 117599. 2. National University Health System, 5 Lower Kent Ridge Road, Singapore 119074. 3. Parkway Cancer Centre, Gleneagles Hospital. 6A Napier Road, Singapore […]

Read More
Apr 22, 2020 Celine Tam 0 comments
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. (Nat Commun, Mar 2020)

April 22, 2020

Kong LR1,2, Mohamed Salleh NAB3, Ong RW4, Tan TZ3, Syn NL3,5, Goh RM5, Fhu CW3, Tan DSW6,7,8, Iyer NG3,9,10, Kannan S11, Verma CS11,12,13, Lim YC14, Soo R5, Ho J5, Huang Y5, Lim JSJ3,5, Yan BJ14, Nga ME14, Lim SG15,16, Koeffler HP3,5,15,17, Lee SC3,5, Kappei D3, Hung HT4, Goh BC18,19,20. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiklr@nus.edu.sg. 2 Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. […]

Read More
Apr 22, 2020 Celine Tam 0 comments
A Unique CDK4/6 Inhibitor: Current and Future Therapeutic Strategies of Abemaciclib. (Pharmacol Res, Feb 2020)

March 4, 2020

Chong QY1, Kok ZH1, Bui NL1, Xiang X2, Li-Ann Wong A3, Peng Yong W3, Sethi G4, Lobie PE5, Wang L6, Goh BC7. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, China. 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Health […]

Read More
Mar 04, 2020 Celine Tam 0 comments
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity. (Cell Rep, Feb 2020)

March 4, 2020

Endoh M1, Baba M2, Endoh T3, Hirayama A4, Nakamura-Ishizu A5, Umemoto T6, Hashimoto M6, Nagashima K7, Soga T4, Lang M8, Schmidt LS9, Linehan WM8, Suda T10. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore; International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan; Institute of Molecular Embryology and Genetics (IMEG), […]

Read More
Mar 04, 2020 Celine Tam 0 comments
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development. (Nat Commun, Feb 2020)

March 4, 2020

Tang SJ1, Shen H1,2, An O1, Hong H1,3, Li J1, Song Y1, Han J1, Tay DJT1, Ng VHE1, Bellido Molias F1, Leong KW1, Pitcheshwar P1,2, Yang H1, Chen L4,5. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2 Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117594, Singapore. 3 Department of Physiology, Yong Loo Lin School […]

Read More
Mar 04, 2020 Celine Tam 0 comments
Dr. Takaomi Sanda Awarded the Yong Loo Lin School of Medicine Research Excellence Award

February 11, 2020

Dr. Takaomi Sanda, Principal Investigator at CSI Singapore, was recently awarded the Yong Loo Lin School of Medicine Research Excellence Award for AY2018/2019. This award honours and celebrates faculty members who have demonstrated excellent achievements as researchers. Dr. Sanda’s exemplary dedication to furthering cancer research has contributed to a better understanding of T-cell acute lymphoblastic […]

Read More
Feb 11, 2020 Celine Tam 0 comments
Feed-forward Regulatory Loop Driven by IRF4 and NF-kB in Adult T-cell Leukemia/Lymphoma. (Blood, Jan 2020)

February 10, 2020

Wong R1, Tan TK2, Amanda S3, Ngoc PCT4, Leong WZ5, Tan SH6, Asamitsu K7, Hibi Y8, Ueda R9, Okamoto T8, Ishida T10, Iida S11, Sanda T6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore. 3Cancer Science Institute of Singapore, Singapore, Singapore. 4Cancer Science Institute of Singapore, National University of Singapore, Lund, Sweden. 5National […]

Read More
Feb 10, 2020 Celine Tam 0 comments
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia. (Gut, Jan 2020)

February 10, 2020

Krishnan V1,2, Lim DXE#1, Hoang PM#1, Srivastava S#3,4, Matsuo J1, Huang KK2, Zhu F4, Ho KY4,5, So JBY6,7, Khor C8, Tsao S9, Teh M3, Fock KM10, Ang TL10, Jeyasekharan AD1, Tan P2,7, Yeoh KG11,5,7, Ito Y12,7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 169857, Singapore. 3Department of Pathology, National University of Singapore, Singapore […]

Read More
Feb 10, 2020 Celine Tam 0 comments
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells. (Mol Cells, Jan 2020)

February 10, 2020

Chuang LSH1, Osato M1, Ito Y1. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Abstract: The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell […]

Read More
Feb 10, 2020 Celine Tam 0 comments
Researchers from CSI Singapore & ASLAN Pharmaceuticals Make Headway in the Treatment of Acute Myeloid Leukemia.

January 22, 2020

Acute Myeloid Leukemia (AML) is a common and aggressive blood cancer and has a relatively poor overall survival rate. Characterized by an overproduction of immature white blood cells, AML has limited treatment options, with chemotherapy being the main therapeutic approach that is currently available. However, chemotherapy is non-selective, which kills fast-dividing leukemic cells as well […]

Read More
Jan 22, 2020 Celine Tam 0 comments
Frontiers in Cancer Science 2019

December 5, 2019

The 11th Frontiers in Cancer Science (FCS) conference took place at The Academia @ SGH from 4 to 6 November 2019. Jointly organised by seven major research institutes in Singapore – Cancer Science Institute of Singapore (CSI Singapore), Duke-NUS Medical School (Duke-NUS), Genome Institute of Singapore (GIS), Institute of Molecular and Cell Biology (IMCB), Lee […]

Read More
Dec 05, 2019 Celine Tam 0 comments