Stories

TFregulomeR reveals transcription factors’ context-specific features and functions. (Nucleic Acids Res, Nov 2019)

December 4, 2019

Lin QXX1, Thieffry D2, Jha S1,3, Benoukraf T1,4. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Computational Systems Biology Team, Institut de Biologie de l’École Normale Supérieure (IBENS), CNRS, INSERM, École Normale Supérieure, PSL Research University, Paris 75005, France. 3Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore. 4Discipline of Genetics, Faculty […]

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Dec 04, 2019 Celine Tam 0 comments
Nanodiamond-Mediated Delivery of a G9a Inhibitor for Hepatocellular Carcinoma Therapy. (ACS Appl Mater Interfaces, Nov 2019)

December 2, 2019

Gu M1,2, Toh TB3, Hooi L2, Lim JJ2, Zhang X2,4, Chow EK1,2,3. Author Information 1Department of Pharmacology, Yong Loo Lin School of Medicine , National University of Singapore , 117600 , Singapore. 2Cancer Science Institute of Singapore , National University of Singapore , 117599 , Singapore. 3The N.1 Institute for Health , National University of Singapore , 117456 , Singapore. […]

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Dec 02, 2019 Celine Tam 0 comments
ASLAN003, a Potent Dihydroorotate Dehydrogenase Inhibitor for Differentiation of Acute Myeloid Leukemia. (Haematologica, Nov 2019)

December 2, 2019

Zhou J1, Quah JY1, Ng Y1, Chooi JY2, Toh SH1, Lin B3, Tan TZ1, Hosoi H1, Osato M4, Seet Q5, Ooi AGL5, Lindmark B5, McHale M5, Chng WJ6. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Republic of Singapore. 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore. 3Department of Hematology-Oncology, National University Cancer Institute, Republic of Singapore. 4Cancer Science Institute […]

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Dec 02, 2019 Celine Tam 0 comments
DNA Epigenetic Signature Predictive of Benefit from Neoadjuvant Chemotherapy in Oesophageal Adenocarcinoma: Results from the MRC OE02 Trial. (Eur J Cancer, Oct 2019)

December 2, 2019

Sundar R1, Ng A2, Zouridis H3, Padmanabhan N4, Sheng T4, Zhang S4, Lee MH4, Ooi WF4, Qamra A4, Inam I5, Hewitt LC6, So JB7, Koh V8, Nankivell MG9, Langley RE9, Allum WH10, Cunningham D11, Rozen SG12, Yong WP8, Grabsch HI13, Tan P14. Author Information 1Department of Haematology-Oncology, National University Health System, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2Cancer and […]

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Dec 02, 2019 Celine Tam 0 comments
CSI Research Scientist Wins ASH Abstract Achievement Award

December 2, 2019

  Congratulations to Dr. Zhou Jianbiao, Senior Research Scientist from Prof. Chng Wee Joo’s team, who has been awarded the American Society of Hematology (ASH) Abstract Achievement Award for his abstract titled “Super-Enhancer Profiling Identifies Novel Oncogenes and Therapeutic Targets in Multiple Myeloma”. He will be presenting his work at the 61st ASH Annual Meeting and […]

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Dec 02, 2019 Celine Tam 0 comments
CSI Singapore Welcomes New Director, Professor Ashok Venkitaraman

November 20, 2019

The Cancer Science Institute of Singapore (CSI Singapore) is pleased to announce the appointment of Professor Ashok Venkitaraman as the new Director of CSI Singapore. Prof Venkitaraman will take over the reins from CSI Singapore’s Founding Director, Professor Daniel G Tenen after a period of transition from his current appointments at the University of Cambridge, […]

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Nov 20, 2019 Celine Tam 0 comments
c-Met activation leads to the establishment of a TGFB-receptor regulatory network in bladder cancer progression. (Nat Commun., Sep 2019)

November 7, 2019

Sim WJ1, Iyengar PV2,3, Lama D4, Lui SKL2, Ng HC1, Haviv-Shapira L5, Domany E5, Kappei D2,6, Tan TZ2, Saie A6,7, Jaynes PW2, Verma CS4,8,9, Kumar AP2,10,11,12, Rouanne M13,14, Ha HK15, Radulescu C16, Ten Dijke P3, Eichhorn PJA17,18,19,20, Thiery JP21,22,23. Author Information 1Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 3Department of Cell and Chemical Biology and Oncode Institute, Leiden University […]

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Nov 07, 2019 Celine Tam 0 comments
RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling. (Cancer Res, Sep 2019)

November 7, 2019

Loh XY1, Sun QY1, Ding LW2, Mayakonda A1, Venkatachalam N1, Yeo MS1, Silva TC3, Xiao JF1, B Doan N4, W Said J4, Ran XB1, Zhou SQ1, Dakle P1, Shyamsunder P1, Koh AP1, Huang RY5, P Berman B3, Tan SY6, Yang H1, Lin DC7, Koeffler HP7. Author Information <sup1Cancer Science Institute of Singapore, National University of Singapore. 2Cancer Science Institute of Singapore, National University of Singapore zipy001@gmail.com. 3Cedars-Sinai Medical Center, Los Angeles, CA, USA., Center for […]

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Nov 07, 2019 Celine Tam 0 comments
A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types. (RNA Biol, Oct 2019)

November 7, 2019

Zhang B1, Babu KR1, Lim CY1, Kwok ZH1, Li J1, Zhou S1, Yang H1,2, Tay Y1,2. Author Information 1Cancer Science Institute of Singapore, National University of Singapore , Singapore , Singapore. 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore. Abstract: RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and […]

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Nov 07, 2019 Celine Tam 0 comments
CSI Graduate Recruitment 2019

October 30, 2019

On 8th October 2019, CSI Singapore hosted the Graduate Recruitment, which was attended by participants from varied backgrounds, ranging from undergraduate students and graduates from NTU and NUS to research staff from National Cancer Centre Singapore (NCCS) and National University Cancer Institute (NCIS). The event served as an excellent platform for participants to gain insights […]

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Oct 30, 2019 Celine Tam 0 comments
CSI Research Fellows Awarded at the 17th International Myeloma Workshop (IMW)

October 9, 2019

  Congratulations to Dr. Teoh Phaik Ju and Dr. Chooi Jing Yuan, research fellows from Prof. Chng Wee Joo’s group who recently won awards to attend and present their research at the 17th International Myeloma Workshop (IMW) which took place from 12-15 September 2019. Held at the Hynes Convention Center in Boston MA, USA, IMW 2019 […]

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Oct 09, 2019 Celine Tam 0 comments
c-Met activation leads to the establishment of a TGFB-receptor regulatory network in bladder cancer progression. (Nat Commun, Sep 2019)

September 30, 2019

Sim WJ1, Iyengar PV2,3, Lama D4, Lui SKL2, Ng HC1, Haviv-Shapira L5, Domany E5, Kappei D2,6, Tan TZ2, Saie A6,7, Jaynes PW2, Verma CS4,8,9, Kumar AP2,10,11,12, Rouanne M13,14, Ha HK15, Radulescu C16, Ten Dijke P3, Eichhorn PJA17,18,19,20, Thiery JP21,22,23. Author Information 1Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 3Department of Cell and Chemical Biology and Oncode Institute, Leiden […]

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Sep 30, 2019 Celine Tam 0 comments
CAV1 – GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer. (Theranostics, Aug 2019)

September 30, 2019

Ali A1, Levantini E2,3,4, Fhu CW1, Teo JT1, Clohessy JG3,5, Goggi JL6, Wu CS1, Chen L1, Chin TM1,7, Tenen DG1,2. Author Information 1Cancer Science Institute Singapore, National University of Singapore, MD6, #12-01, 14 Medical Drive, Singapore 117599. 2Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. 3Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 4Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy. […]

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Sep 30, 2019 Celine Tam 0 comments
Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/B-catenin-driven hepatocellular carcinoma. (J Hepatol, Sep 2019)

September 30, 2019

Toh TB1, Lim JJ2, Hooi L2, Rashid MBMA3, Chow EK4. Author Information 1The N.1 Institute for Health (N.1), National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address: lsittb@nus.edu.sg. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, […]

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Sep 30, 2019 Celine Tam 0 comments
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. (Gastroenterology, Aug 2019)

September 30, 2019

Tan JL1, Li F2, Yeo JZ1, Yong KJ2, Bassal MA3, Ng GH4, Lee MY4, Leong CY5, Tan HK2, Wu CS2, Liu BH2, Chan TH2, Tan ZH2, Chan YS4, Wang S4, Lim ZH4, Toh TB2, Hooi L2, Low KN5, Ma S4, Kong NR6, Stein AJ6, Wu Y7, Thangavelu MT4, Suzuki A8, Periyasamy G4, Asara JM9, Dan YY10, Bonney GK11, Chow EK12, Lu GD13, Ng HH4, Kanagasundaram Y5, Ng SB5, Tam WL14, Tenen DG15, Chai L16. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore; Genome […]

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Sep 30, 2019 Celine Tam 0 comments
CSI Deputy Director, Prof. Goh Boon Cher, Receives National Outstanding Clinician Scientist Award

September 17, 2019

  CSI extends our heartiest congratulations to our Deputy Director, Prof. Goh Boon Cher, for being awarded the National Outstanding Clinician Scientist Award at this year’s National Medical Excellence Awards (NMEA) ceremony. The NMEA is a national-level award to recognize the efforts of clinicians, clinician-scientists and other healthcare professionals for their contributions. Conferred by the […]

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Sep 17, 2019 Celine Tam 0 comments
IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma. (Haematologica, Aug 2019)

August 31, 2019

Teoh PJ1, Chung TH2, Chng PYZ2, Toh SHM2, Chng WJ3. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore; mdctpju@nus.edu.sg. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Abstract: 1q21 amplification (1q21(amp)) is an important prognostic marker in multiple myeloma. […]

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Aug 31, 2019 Celine Tam 0 comments
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. (Gut, Aug 2019)

August 31, 2019

Chen L#1, Huang M#2, Plummer J#3, Pan J#4, Jiang YY#5, Yang Q1, Silva TC3, Gull N3, Chen S3, Ding LW5, An O5, Yang H5, Cheng Y6, Said JW7, Doan N7, Dinjens WN8, Waters KM9, Tuli R10, Gayther SA3, Klempner SJ11,12, Berman BP3, Meltzer SJ6, Lin DC13, Koeffler HP1,5. Author Information 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. 2School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China dchlin11@gmail.com huangml@suda.edu.cn. 3Center for Bioinformatics and Functional […]

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Aug 31, 2019 Celine Tam 0 comments
Interleukin-6 promotes a STAT3-PRL3 feedforward loop via SHP2 repression in Multiple Myeloma. (Cancer Res, Jul 2019)

August 31, 2019

Chong PSY1, Zhou J2, Lim JSL1, Hee YT3, Chooi JY2, Chung TH2, Tan TZ4, Zeng Q5, Waller DD6, Sebag M6, Chng WJ7. Author Information 1CSI Singapore, Cancer Science Institute of Singapore. 2Cancer Science Institute of Singapore, National University of Singapore. 3Nanyang Technological University. 4CSI, Cancer Science Institute, NUS. 5Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research). 6McGill University. 7Hematology-Oncology, National […]

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Aug 31, 2019 Celine Tam 0 comments
CSI Staff and Students Bag Multiple Awards at NCAM 2019

August 29, 2019

Congratulations to our PhD graduate students and staff for receiving several awards during the 6th NCIS Annual Research Meeting (NCAM) 2019. Co-organised by the National University Cancer Institute, Singapore (NCIS) and CSI Singapore, the annual conference was held on 2nd August 2019 at National University Health System, Singapore. The meeting is a full-day program attended […]

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Aug 29, 2019 Celine Tam 0 comments