Polly Leilei CHEN
The human genome encodes RNA molecules that instruct the behaviour of cancer cells. Leveraging on the next-generation sequencing technologies, well-established cancer cell lines and animal models, Dr Polly Leilei Chen’s group aims to identify the harmful changes that will occur in RNA molecules after it is made from DNA. It is critical to uncover how these changes trigger a cell to develop into cancer which can eventually lead to the unsatisfactory treatment outcomes for patients with cancers (particularly esophageal, stomach, colon and liver cancer). The long-term goal of Dr Chen’s team is to develop novel cancer therapies targeting these cancer-associated RNA changes.
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