Dennis KAPPEI

About 98% of the human genome consists of non-coding DNA and more than half harbors repetitive sequences. At the moment, the function of most of these non-coding elements remains elusive despite an association of several of these elements with diseases such as cancer, diabetes and aging-related disorders. This is partly due to the fact that the modern molecular biology toolbox is adapted to research protein-coding genes. The study of protein binders to non-coding DNA sequences and RNA structures is an attractive entry point to examine the function of non-coding elements. To that end, we have established a quantitative mass spectrometry approach to identify proteins binding to nucleic acids. Applying this technique to telomeres, repetitive DNA at the extremity of chromosomes, we identified previously unreported telomeric DNA- and telomeric RNA-binders. Our work serves as a blueprint to functionally dissect additional repetitive elements as well as other important non-coding loci.

Principal Investigator, Cancer Science Institute of Singapore, NUS
Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS

Year(s) Degree (if applicable) Institute
2013 Ph.D. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
2007 M.S. Ecole Normale Supérieure, Paris
2005 B.S. University of Leipzig
2019-present Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
2018-present Principal Investigator, Cancer Science Institute of Singapore, NUS
2015-present Head, Quantitative Proteomics Core, Cancer Science Institute of Singapore, NUS
2015-2018 Special Fellow, Cancer Science Institute of Singapore, NUS
2013-2014 Postdoctoral Fellow, TU Dresden
2013 Georg Helm Prize, TU Dresden
2005-2007 Rotary Foundation Multi-Year Ambassadorial Scholarship
2003-2007 German National Merit Foundation Undergraduate Fellowship