Jean-Paul THIERY

Prof Jean-Paul Thiery’s focus of research is to unravel the mechanisms of invasion and metastasis of carcinoma cells. His seminal contributions in the study of bladder carcinoma have led to the discovery of molecular mechanisms governing the formation of superficial or invasive tumors.

Biosketch

Prof Jean-Paul Thiery’s focus of research is to unravel the mechanisms of invasion and metastasis of carcinoma cells. His seminal contributions in the study of bladder carcinoma have led to the discovery of molecular mechanisms governing the formation of superficial or invasive tumors. His current studies involve oncogenomics and functional approaches to characterise breast carcinoma basal subtypes and ovarian carcinoma. Prof Thiery is also known for his studies on mechanochemistry of cell adhesion and migration and for his work on the ontogeny of neural crest.

Senior Principal Investigator, Cancer Science Institute of Singapore, NUS
Principal Investigator, Institute of Molecular and Cell Biology, A*STAR

Year(s) Degree (if applicable)
1964 – 1970 University Louis Pasteur, Strasbourg (France)
1965 Mathematics-Physics-Chemistry Competitive examination, Ecole Nationale Supérieure de Chimie de Strasbourg
1966 Crystallography, General Chemistry, Mineral Chemistry, Experimental Physics
1967 Organic Chemistry, Industrial Chemistry, General Chemistry
1968 Masters in Physical Chemistry Engineering Diploma in Chemistry (Ecole Nationale Supérieure Chimie Strasbourg), placed first in the year.
1968 Diploma Organic Chemistry of Natural Substances
1974 Doctorat d’Etat Thesis, Institut Jacques Monod, Paris
2008 – Present Senior Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore
2007 – Present Principal Investigator , Institute of Molecular Cell Biology (IMCB), A*STAR
2007 – Present Chief Scientific Officer, Experimental Therapeutic Centre, A*STAR
2007 – Present Adjunct Professor of Pathology, National University of Singapore
2007 – 2011 Deputy Director, Institute of Molecular Cell Biology (IMCB), A*STAR
2003 – 2006 Director Department of Translational Research – Medical division Institut Curie
2003 – 2006 Scientific Officer Ministry of Research and Technology
1999 Director of Research CNRS Exceptional Class
1995 – 2003 Director of the laboratory of ‘Subcellular Structure and Cellular Dynamics’ of the CNRS and the Institut Curie, Paris
1989 Director of Research CNRS First Class
1987 – 1994 Director of the Laboratory of Physiopathology of Development of the CNRS and Ecole Normale Supérieure, Paris
1982 – 1987 Director of Research CNRS, Institute of Embryology, Nogent sur Marne, France
1978 – 1982 Senior Research Associate CNRS, Institute of Embryology, CNRS and the Collège de France, Nogent sur Marne, France
1977 Research Associate, The Rockefeller University, New York
1976 Fogarty Postdoctoral Fellowship (NIH)
1975 Fellow of the International Center for Cancer Research, Lyon, France
1975 – 1977 Postdoctoral fellow, laboratory of Professor Gerald M. Edelman, The Rockefeller University, New York
1970 – 1974 Research position, CNRS, Institut Jacques Monod, Paris
1968 – 1970 Research position at the Centre National de la Recherche Scientifique (CNRS) in the laboratory of Dr. Bernardi, Institute of Macromolecular Substances, Strasbourg, France

Research

The Ovarian Cancer Research Programme is aimed to utilize systems approaches in both in vitro and in vivo preclinical models to achieve translational needs for novel diagnostic and therapeutic strategies. This Programme is jointly led by Jean Paul Thiery and Ruby Yun-Ju Huang. The current area of investigation in our laboratory is to understand the contribution of epithelial plasticity in cancer “stemness”, tumour progression and therapeutic responses and to decipher the regulatory mechanisms behind it. The ultimate goal is to achieve personalized medicine in the diagnosis and treatment for ovarian cancer patients.

Selected Publications

1. Tan T.Z., Huang R.Y.H , Miow Q.H., Wong M.K.,Ye J., Lau J.A., Wu M.C., Bin Abdul Hadi L.H., Soong R., Choolani M , Ben Davidson B., Nesland J., Matsumura N., Mandai M., Konishi I., Chang J.T., Thiery J.P*., S. Mori (2012) A Molecular Classification Scheme of Ovarian Serous Adenocarcinoma To Explore Novel Therapeutic Strategies. EMBO Mol Med in press *CoPI

2. Bidard, FC, Pierga, JY, Soria, JC and Thiery, JP(2013) A clinical perspective on the metastatic process. Nat Rev Clin Onc. Epub

3. Laiyi L, Chu YS Thiery JP Lim CT and I Rodriguez (2013) Microfluidic cell trap array for controlled positioning of single cells on adhesive micropatterns. Lab On Chip Epub.

4. Chua KN, Sim WJ, Racine V, Shi Yl, Goh BC and JP Thiery (2012) A Cell-Based Small Molecule Screening Method for Identifying Inhibitors of Epithelial-Mesenchymal Transition in Carcinoma..PLoS One Epub

5. Voon DC, Wang H, Koo JKW, NguyenTAP, Hor YT, Chu YS, Ito K, Fukamachi H, Shing Chan SK, Thiery JP* and Y Ito. (2012) Runx3 protects gastric epthelium against epithelial-mesenchymal transition induced cellular plasticity and tumorigenicity. Stem Cells Epub *CopI

6. Toh B., X. Wang, J. Keeble, W. J. Sim ,K. Khoo,M. Kato, A. Prevost-Blondel J.P. Thiery* and J.P. Abastado.(2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PloS Biology Epub *CoPI

7. Martinez-Rico C, Pincet F., Thiery JP*. and Dufour S.(2010). Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src kinase activation and actomyosin contractility. J.Cell. Science 123: 712-722.*CoPI

8. Thiery JP, Acloque H, Huang YJH and Nieto A. (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.

9. Taddei I, Deugnier MA, Faraldo MM, Petit V, Bouvard D, Medina D, Fässler R, Thiery JP and Glukhova MA.(2008) beta1integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol 10: 716-722.*CoPI

10. Bollet MA, Servant N., Neuvial P., Decraene C., Lebigot I., Meyniel JP., De Rycke Y., Savignoni A., Rigaill G., Fourquet A., Sigal-Safrani B.,Barillot E., Thiery JP (2008) High resolution mapping of DNA breakpoints to define true recurrences among ipsilateral breast cancers. J. Natl. Cancer. Inst. 100:48-58.