Kevin WHITE

The White lab works in the fields of functional genomics and systems biology, using large-scale biological data-sets to generate biological insights and create new directions in diagnostic and therapeutic development to treat cancer and other disorders. Currently, focusing on developing new approaches for accelerating precision medicine through the development of nucleic acid based therapeutics and cellular engineering.

mdckpw[at]nus.edu.sg

Biosketch

Principal Investigator, Cancer Science Institute of Singapore, NUS
Professor, Biochemistry and Precision Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Program Director, Nucleic Acids Therapeutics, GIS A*STAR
Founder and Chairman, Provaxus Inc.

2007-2009 Pritzker Fellow, The University of Chicago Pritzker School of Medicine
2006-2009 Investigator, Searle Chicago Biomedical Consortium
2008 Crain’s Business 40 under 40
2004-2008 Arnold and Mabel Beckman Young Investigator
2003-2006 W. M. Keck Distinguished Young Investigator in Biomedical Sciences
2000-2005 NIH/NHGRI Genome Scholar Award
1998-2000 Helen Hay Whitney Foundation Fellow, Genome Technology Center, Stanford University
1993-1998 HHMI Predoctoral Fellowship, Department of Developmental Biology, Stanford University
1993 B.S., M.S. awarded magna cum laude, Phi Beta Kappa, Belknap Award for Outstanding Graduating Senior in the Natural Sciences at Yale University

Research

Prof. White has worked at the interface of technology development and application to biological problems for over 20 years. The teams that he leads are committed to using genomic and computation/analytics tools, and an iterative experimental systems biology approach, to distill explanatory or predictive models from the complexity of multi-genic and epigenetic processes that underlie development, evolution and disease. Over the years Prof White’s laboratory has developed and used experimental and computational genomics and systems biology toolkits to delineate the basic architecture of transcriptional genomic systems in the development of model systems, to uncover basic principles of gene regulatory evolution in model organisms and humans, to identify conserved oncogenes and tumor suppressors, and to shed light on the transcriptional networks that go awry in cancers and discover novel drug targets in those same cancers as a result. Prof White’s lab has also contributed significantly to the mapping and functional characterization of the human genome in general through the NIH Encyclopedia of DNA Elements (ENCODE) project, and to mapping the genomic architecture of the human brain in neuropsychiatric disorders through the NIH PsychENCODE project, including the systematic identification and characterization of non-coding regions of the human genome predicted to be enhancers that contribute to the development of neuropsychiatric diseases. In the last few years Prof. White’s team has also developed tools and systems for managing and mining massive genomic datasets. They have thus discovered and characterized in model cell systems dozens of novel recurrent fusion genes in human cancers, identified previously unrecognized risk factors for human diseases including cancers, and they have developed predictive algorithms that match specific cancer patients to specific treatments. Prof White is also actively engaged in commercialization of genomic and systems biology approaches for developing novel diagnostics and therapeutics.  He has had founder and executive roles at companies such as Tempus Labs, HealthSeq Asia, and Provaxus.

Selected Publications

1. Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science. 2009 Feb 27;323(5918):1218-22. doi: 10.1126/science.1157669. Epub 2009 Jan 22. PMID: 19164706; PMCID: PMC2756524.

2. Hua S, Kittler R, White KP. Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell. 2009 Jun 26;137(7):1259-71. doi: 10.1016/j.cell.2009.04.043. PMID: 19563758; PMCID: PMC3374131.

3. Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24;471(7339):527-31. doi: 10.1038/nature09990. PMID: 21430782; PMCID: PMC3179250.

4. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 6;489(7414):57-74. doi: 10.1038/nature11247. PMID: 22955616; PMCID: PMC3439153.

5. Kittler R, Zhou J, Hua S, Ma L, Liu Y, Pendleton E, Cheng C, Gerstein M, White KP. A comprehensive nuclear receptor network for breast cancer cells. Cell Rep. 2013 Feb 21;3(2):538-51. doi: 10.1016/j.celrep.2013.01.004. Epub 2013 Jan 31. PMID: 23375374.

6. Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümü? ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB. Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018 Dec 14;362(6420):eaat8464. doi: 10.1126/science.aat8464. PMID: 30545857; PMCID: PMC6413328.

7. Beaubier N, Tell R, Lau D, Parsons JR, Bush S, Perera J, Sorrells S, Baker T, Chang A, Michuda J, Iguartua C, MacNeil S, Shah K, Ellis P, Yeatts K, Mahon B, Taxter T, Bontrager M, Khan A, Huether R, Lefkofsky E, White KP. Clinical validation of the tempus xT next-generation targeted oncology sequencing assay. Oncotarget. 2019 Mar 22;10(24):2384-2396. doi: 10.18632/oncotarget.26797. PMID: 31040929; PMCID: PMC6481324.

8. Beaubier N, Bontrager M, Huether R, Igartua C, Lau D, Tell R, Bobe AM, Bush S, Chang AL, Hoskinson DC, Khan AA, Kudalkar E, Leibowitz BD, Lozachmeur A, Michuda J, Parsons J, Perera JF, Salahudeen A, Shah KP, Taxter T, Zhu W, White KP. Integrated genomic profiling expands clinical options for patients with cancer. Nat Biotechnol. 2019 Nov;37(11):1351-1360. doi: 10.1038/s41587-019-0259-z. Epub 2019 Sep 30. PMID: 31570899.

9. ENCODE Project Consortium, Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Van Nostrand EL, Freese P, Gorkin DU, Shen Y, He Y, Mackiewicz M, Pauli-Behn F, Williams BA, Mortazavi A, Keller CA, Zhang XO, Elhajjajy SI, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM, Myers RM, Ren B, Graveley BR, Gerstein MB, Pennacchio LA, Snyder MP, Bernstein BE, Wold B, Hardison RC, Gingeras TR, Stamatoyannopoulos JA, Weng Z. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020 Jul;583(7818):699-710. doi: 10.1038/s41586-020-2493-4. Epub 2020 Jul 29. PMID: 32728249; PMCID: PMC7410828.

10. Zhang J, Lee D, Dhiman V, Jiang P, Xu J, McGillivray P, Yang H, Liu J, Meyerson W, Clarke D, Gu M, Li S, Lou S, Xu J, Lochovsky L, Ung M, Ma L, Yu S, Cao Q, Harmanci A, Yan KK, Sethi A, Gürsoy G, Schoenberg MR, Rozowsky J, Warrell J, Emani P, Yang YT, Galeev T, Kong X, Liu S, Li X, Krishnan J, Feng Y, Rivera-Mulia JC, Adrian J, Broach JR, Bolt M, Moran J, Fitzgerald D, Dileep V, Liu T, Mei S, Sasaki T, Trevilla-Garcia C, Wang S, Wang Y, Zang C, Wang D, Klein RJ, Snyder M, Gilbert DM, Yip K, Cheng C, Yue F, Liu XS, White KP, Gerstein M. An integrative ENCODE resource for cancer genomics. Nat Commun. 2020 Jul 29;11(1):3696. doi: 10.1038/s41467-020-14743-w. PMID: 32728046; PMCID: PMC7391744.