We are investigating the mechanism behind the development of leukaemia by analyses of a key leukaemia gene, RUNX1. Through these studies, we aim to develop novel diagnostic and therapeutic methods. To achieve this, we use a range of experimental platforms, such as mouse models as well as standard biological and chemical techniques. Our best known research accomplishment is the detection of RUNX1 point mutation in acute myeloid leukaemia. This genetic change is included in the World Health Organization (WHO) leukaemia classification and being examined globally whenever a leukaemia diagnosis is made.