Senior Principal Investigator, Cancer Science Institute of Singapore, NUS
Executive Director, Genome Institute of Singapore
Professor, Cancer and Stem Cell Biology Programme, Duke-NUS Medical School
Director, Duke-NUS Genome Biology Facility
Director, SingHealth Duke-NUS Institute of Precision Medicine (PRISM)
Principal Investigator (Adjunct), National Cancer Centre, Singapore
Professor (Adjunct), Department of Physiology, NUS
Epigenetics is the study of chemical modifications affecting DNA that do not involve overt changes in DNA sequence, and epigenetic alterations play an important role in cancer biology. Our laboratory is interested in applying integrative (epi)genomic approaches to address biological questions in cancer. We have a specific focus on gastric cancer, a leading cause of global cancer mortality. We seek to identify the complete repertoire of oncogenic pathways regulating specific aspects of the gastric cancer phenotype, and to use this knowledge to devise rational therapeutic strategies for gastric cancer patients.