Down-regulation of tumor suppressors or expression of oncogenes is a hallmark feature of cancers. These alterations in the transcriptome arise as a consequence of a malfunction in the chromatin organization. Chromatin remodeling complexes play an important role in maintaining this organization as they create a histone code that is read by specific readers resulting in an active or repressed chromatin. Dr Jha is interested in studying the regulation of chromatin remodeling complexes and their role in cancer prevention. His research focuses on understanding the function of TIP60 (a histone acetyltransferase) as a tumor suppressor. Dr Jha has discovered TIP60 to be down-regulated by E6, a viral oncogene expressed by human papillomavirus (HPV). Interestingly, TIP60 is down-regulated in multiple cancers. Using TIP60 as a candidate molecule, he plans to investigate how deregulation of this chromatin remodeling complex can lead to cancer.