Wai Leong TAM
Cancer progression is orchestrated by complex alterations in cellular behaviors that enable the survival of, and colonization by, cancer cells in the human body. Disturbances in cell states underlie disease progression and clinical outcomes. Underpinning the control of cancer cell states are metabolic reprogramming events, i.e., why are the nutritional needs of cancer cells unique or different? Many fundamental cancer pathways are now known to impinge on cell metabolism, and strategies focusing on disrupting specific metabolic processes to control disease progression have gained considerable interests. Leveraging on functional genomic approaches, and in close collaboration with clinician partners, Dr Wai Leong Tam’s group seeks to gain insights into the precise control of cancer cell states, and specific targeting of metabolic pathways, for the development of selective therapeutics against cancer resistance and metastasis.