Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3 (Blood, Oct 2012)

Acute myeloid leukemia (AML) is the most common type of leukemia in adults with improving but still limited treatment possibilities. It arises as a result of malignant transformation of myeloid progenitor cells. Among the contributing genetic lesions, mutations in FMS-like tyrosine kinase 3 (FLT3) occur in approximately 30% of patients, mostly in the form of