Translating Metastasis-related Biomarkers to the Clinic – Progress and Pitfalls (Nat Rev Clin Oncol, Feb 2013)

The risk of metastasis, or “tumor spread”, is estimated based on clinical and pathological criteria referring to the primary tumor. However, this risk does not consider the potential expansion of micrometastatic cancer cells, which are too small to be detected. Therefore, current prognosis estimates are likely to be partly incorrect, which poses a challenging issue.

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells (Mol Cell, Feb 2013)

To guarantee blood supply throughout adult life hematopoietic stem cells (HSCs) need to carefully balance between self-renewing cell divisions and quiescence. Identification of genes controlling HSC self-renewal is of utmost importance given that HSCs are the only stem cells with broad clinical applications. While several regulators have been identified which control this mechanism, we here

Recoding RNA Editing of AZIN1 Predisposes to Hepatocellular Carcinoma (Nat Med., Feb 2013)

Liver cancer, also known as hepatocellular carcinoma (HCC), is the major malignancy of the liver and the third leading cause of cancer-related deaths globally. Prognosis remains bleak, with most patients dying within 6 to 20 months, and treatment, especially if surgery is not curative, has been largely ineffective. Associated with hepatitis viruses and other causes

Congratulations to winners of the YLLSoM 3rd Annual Graduate Scientific Congress 2013!

Congratulations to 5 of our PhD students for their achievements at the Annual Graduate Scientific Congress 2013! The Yong Loo Lin School of Medicine 3rd AGSC offers graduate students the opportunity to interact, share and showcase their scientific discoveries through oral and poster presentations. Held on 30th January 2013, the theme for this year’s congress