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Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma (N Engl J Med, Jun 2013)

Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. In the heterogeneous group of HCC, those with embryonic stem cell (ESC)/ progenitor cell gene expression characteristics have the worst prognosis. We report an oncogene in HCC, SALL4, which allows identification of a progenitor HCC subset with worse prognosis, and offers a potential

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma (Gut, June 2013)

Objective Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. Design By utilizing large scale transcriptome sequencing of three paired HCC clinical specimens and their adjacent non-tumour (NT)