DNMT1-interacting RNAs block gene-specific DNA methylation (Nature, Oct 2013)

DNA methylation is a process in which certain building blocks of DNA, the genetic code, are chemically modified without resulting in a change in the code itself. As such, it is considered an epigenetic modification. DNA methylation was first described almost a century ago, but the rules governing its establishment and maintenance remain elusive. DNA

Dr Yong Kol Jia awarded the Ray Wu Prize for Excellence in Life Sciences

We are happy to announce that Dr Yong Kol Jia, Research Fellow under Prof Daniel Tenen’s group, has been selected as a recipient for the 2013 Ray Wu Prize for Excellence in Life Sciences. Serving to recognise innovation, independent thinking and dedication in Life Science research, the award will be presented at the 4th Ray

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization (Nat Struc Mol Biol, Oct 2013)

Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer. Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated mutation, BRCA2D2723H, and that controls the nuclear localization of BRCA2 and its cargo, the recombination enzyme RAD51. A nuclear export signal (NES) in BRCA2 is masked by its interaction with a