An emerging role of PARK2 in Cancer (J Mol Med, Jan 2014)

An emerging role of PARK2 in Cancer Journal of Molecular Medicine. 2014 Jan. PARK2 (PARKIN) is an E3 ubiquitin ligase involved in multiple signaling pathways and cellular processes. Activity of PARK2 is tightly regulated through inter- and intra-molecular interactions. Dysfunction of PARK2 is associated with the progression of parkinsonism. Notably, frequent PARK2 inactivation has been

Study reveals LAMC2 as potential therapeutic target for treatment of anaplastic thyroid carcinoma

Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR J Clin Endocrinol Metab. Jan 2014. Context: Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy having no effective treatment. Laminin subunit-γ-2 (LAMC2) is an epithelial basement membrane protein involved in cell migration

Adenosine-to-inosine RNA editing mediated by ADARs in Esophageal Squamous Cell Carcinoma (Cancer Research, Dec 2013)

Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is a heterogeneous tumor displaying a complex variety of genetic and epigenetic changes. Aberrant RNA editing of adenosine-to-inosine (A-to-I) as it is catalyzed by adenosine deaminases (ADARs) represents a common post-transcriptional modification in certain human diseases. In this study, we investigated the status