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Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin. (Sci Rep, Aug 2017)

Garg M1,2, Kanojia D3, Mayakonda A3, Ganesan TS4, Sadhanandhan B4, Suresh S4, S S4, Nagare RP4, Said JW5, Doan NB5, Ding LW3, Baloglu E6, Shacham S6, Kauffman M6, Koeffler HP3,7. Author information 1 Cancer Science Institute (CSI) of Singapore, National University of Singapore, Singapore, Singapore. manoj.garg@cancerinstitutewia.org. 2 Department of Medical Oncology and Clinical Research, Cancer

Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer. (Nat Genet, Aug 2017)

Babu D1, Fullwood MJ1,2. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 School of Biological Sciences, Nanyang Technological University, Singapore, and the Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. Abstract ERG overexpression in prostate cancers promotes the development of widespread changes in

CSI Singapore Won Three Awards at the Scientific Frontiers in Natural Product Based Drugs 2017

Congratulations to our CSI Research Assistants, Ms Madhu Mathi Kanchi and Ms Eve Wang Chao, and PhD student, Ms Shreya Kar, from Dr Alan Prem Kumar’s group for winning awards at the International Conference on Scientific Frontiers in Natural Product Based Drugs (SFNPBD) 2017! This conference was co-organized by the Department of Pharmacology, Yong Loo