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A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase. (J Hematol Oncol, Mar 2018)

Zhou J1,2, Toh SH1, Chan ZL1, Quah JY1, Chooi JY2, Tan TZ1,3, Chong PSY1, Zeng Q4, Chng WJ5,6,7. 1 Cancer Science Institute of Singapore, Singapore, Singapore. 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 3 Translational Centre for Development and Research, National University Health System, Singapore, Singapore.

Increased Expression of the Long Non-coding RNA LINC01503, Regulated by TP63, in Squamous Cell Carcinoma and Effects on Oncogenic Activities of Cancer Cell Lines. (Gastroenterology, Feb 2018)

Xie JJ1, Jiang YY2, Jiang Y2, Li CQ3, Chee LM2, An O2, Mayakonda A2, Ding LW2, Long L4, Sun C4, Lin LH5, Chen L5, Wu JY4, Wu ZY6, Cao Q5, Fang WK4, Yang W7, Meltzer SJ8, Yang H2, Fullwood M9, Xu LY10, Li EM11, Lin DC12, Koeffler HP13. 1 Department of Biochemistry and Molecular Biology,

Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research. (PLoS Biol, Feb 2018)

Lim WK1,2, Davila S1,3, Teo JX1, Yang C4, Pua CJ4, Blöcker C2, Lim JQ5, Ching J3, Yap JJL6, Tan SY6, Sahlén A6, Chin CW6, Teh BT1,2,7,8,9, Rozen SG1,2,10, Cook SA1,3,4,11,12, Yeo KK6, Tan P1,2,9,13. 1 SingHealth Duke-NUS Institute of Precision Medicine, Singapore. 2 Cancer and Stem Biology Program, Duke-NUS Medical School, Singapore. 3 Cardiovascular and

Lab-grown liver tumours help Singapore scientists to develop anti-cancer drugs (Straits Times, Feb 2018)

(From left) Dr Toh Tan Boon, research fellow from the Cancer Science Institute of Singapore NUS, Dr Eliza Fong, Professor Hanry Yu from the Department of Physiology and principal investigator from the Cancer Science Institute of Singapore NUS, Dr Edward Kai-Hua Chow.ST PHOTO: LEE JIA WEN SINGAPORE - A team of scientists has managed to