Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Positions Available - Melissa Fullwood Lab

1. Research Fellow

A full-time postdoctoral position is available for a Ph.D. graduate in the Fullwood Lab. The focus of the lab is on understanding chromatin interactions in cancer.

We are seeking highly motivated Ph.D. graduates with backgrounds in biological sciences, genomics, or other related fields who are interested in using a variety of methods to interrogate chromatin interactions in cancer, working with human cell lines, mouse models and clinical samples.

The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, and compete for fellowships. Candidates are required to have an understanding of imaging, mouse models, molecular biology and cell biology, a proven track record in the form of publications in top English language journals, and the ability to communicate in written and spoken English. Candidates must be willing to work with mouse models and clinical samples. Any experience in bioinformatics and epigenomics will be valued.

2.Research Assistant

A full-time Research Assistant position is available.

The focus of the lab is on understanding chromatin interactions in cancer.

We are seeking highly motivated Honours’ degree holders with intention to pursue Ph.D.  Candidates with backgrounds in biological sciences or related fields who are interested in doing research into epigenomics are invited to apply.  Candidates should be comfortable working independently and with other team members and be willing to work flexible schedules to manage workload on weekend or before/after normal working hours. Candidates are required to have an understanding of molecular biology and cell biology (any experience with bioinformatics is a plus) and the ability to communicate in written and spoken English, and present research findings in group meetings. Fresh graduates with honors/final year project experience are welcome to apply.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief paragraph on why you want to join the Fullwood lab.

Dr Melissa J. Fullwood, PhD
Principal Investigator, CSI Singapore
Email: melissa.fullwood[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow Positions Available – Daniel G Tenen Lab

1. Postdoctoral Fellow (Molecular or Cell Biology)

A postdoctoral position is available immediately for MD and/or Ph.D. fellows interested in gene regulation and epigenetics in cancer and stem cell biology. Advantages of working in the Cancer Science Institute of Singapore include grants for senior postdoctoral fellows in order to assist them in the transition to junior faculty, the availability to recruit outstanding graduate students to their projects, and the opportunity to work with some excellent bioinformaticians and genomicists.

The main focus is the role of RNA in epigenetic regulation, particularly in hematopoiesis and leukemia. Examples are regulation of key transcription factors by RNAs, including long noncoding RNAs (Ebralidze et al, Genes Dev 22:2085, 2008), RNA editing in cancer (Chen et al, Nature Medicine 19:209, 2013), how RNAs modulate and can be utilized to alter epigenetics marks (Di Ruscio et al, Nature 503:371, 2013), and the role of epigenetic changes in development of the cancer phenotype (Amabile et al, Nat Commun. 6:709, 2015). But other projects involving gene regulation and cancer are ongoing as well. Candidates must have a proven track record in research and laboratory work in the form of publications in top English language journals. Ability to communicate in written and spoken English is required.

2. Postdoctoral Fellow (Bioinformatics)

Postdoctoral positions are available immediately for PhD with experience in Bioinformatics (computational genomics). The focus of the lab is on transcription factors and gene regulation, and their relationship to normal differentiation and cancer. Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (ChIP-seq, RIP-seq, exo-seq, RNA-seq, and microarray) data sets and also utilize publically available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms. Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R, or other related programming knowledge), and excellent skills in handling genomic databases.

Applications for both positions should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees. Please also include a summary of your research experience and a brief description of intent of research in the form of two short proposals.

Please indicate clearly on your application the postdoctoral position you are applying for and send your application to:

Prof Daniel G. Tenen
Senior Principal Investigator, CSI
Email: csi_careers[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow Positions Available – Yoshiaki Ito Lab

1. Postdoctoral Fellow (Mechanism of Cancer Development)

A postdoctoral position is available immediately. The group explores the multiple layers of tumor suppressor mechanisms that defend against tumor initiation as well as progression to late malignancy. Using mouse models, organoid cultures and molecular biology techniques, we trace the pathogenesis of cancer from stem cells, to precancerous adenomas, and finally to full-blown adenocarcinoma (Gastroenterology 152: 218-231, 2017).  We investigate how oncogenic stress response mechanisms, DNA repair networks (Cell Reports 8:767-782, 2014) and mitosis (PNAS 113:6490-6495, 2016) crosstalk with master regulators of cellular transcriptional programs to protect against carcinogenic insults in gastric (Gastroenterology 140:1536-1546, 2011), lung (Cancer Cell 24:603-616, 2013), colon (Cancer Cell 14:226-237, 2008) and breast cancer cells.

The successful candidate will focus on the investigation of molecular and clinical roles of RUNX in DNA repair mechanisms including the Fanconi anemia pathway. The group found that RUNX1 and RUNX3 interact with Fanconi anemia pathway proteins FANCD2 and FANCI to recruit them to the site of repair (Cell Reports 8:767-782, 2014). These novel roles of RUNX proteins are not related to transcription regulation, and are equally important in solid tumors including gastric cancer. The absence of RUNX function is also associated with a defective Fanconi-BRCA pathway and hypersensitivity to PARP inhibitors. Moving forward, the group aims to investigate the activity of RUNX in conjunction with these inhibitors, which will provide insights into their effective drug use in RUNX-deficient cancers.

Candidates should be PhD and/or MD PhD graduates with strong background in molecular biology, biochemistry and cell biology. Candidates with significant experience in the field of transcriptional regulation, histone modification, gene expression profile and ChIP sequence analysis are highly preferred.

2. Postdoctoral Fellow (Gastric Carcinogenesis)

A postdoctoral position is available immediately for PhD. The focus of the lab is on investigation of the roles of RUNX and other genes involved in step-wise gastric carcinogenesis. One of the ongoing project is to generate genetically modified mice to test carcinogenic steps in gastric cancer development as well as to generate organoid culture from gastric cancer stem cells from mouse and human.

Candidates should be PhD and/or MD PhD graduates with backgrounds in animal experiments, molecular biology, cell biology, bioinformatics, or other related fields. The successful candidate will support the Principal Investigator in designing experiments, conducting experiments and data analysing.

 

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees. Please also include a summary of your research experience and a brief description of intent of research in the form of two short proposals.

Please indicate clearly on your application the postdoctoral position you are applying for and send your application to:

Prof Yoshiaki Ito
Senior Principal Investigator, CSI
Email: csiitoy[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow / Research Assistant – Tam Wai Leong Lab

Position for a Bioinformatician at the research officer or post-doctoral level is available immediately at Dr Tam’s lab . The laboratory is broadly interested in understanding the contributions of cancer stem cells to malignant cancer progression. We focus on dissecting the distinctive properties of cancer stem cells in various carcinomas, and exploit these traits as vulnerabilities towards the development of targeted cancer therapies. The candidate will engage in bridging the gap between bioinformatics and biology. He/she will work on cancer genomics, transcriptomics, epigenomics and metabolomics in partnership with a ‘wet lab’ postdoc.

Applicants should have relevant training in the field of computational biology and biomedical sciences. Prior experience as a bioinformatician is highly desirable. Candidates are expected to be highly motivated, creative, and strongly enthusiastic in addressing challenging problems in the field of cancer.

Requirements:

  • Bachelor’s degree or Ph.D. in Computational Science, Bioinformatics, or Computational Biology
  • Must have an interest in exploring the interface between biology, bioinformatics and computing
  • Track record of scientific achievement and demonstrated creative abilities
  • Experience in some these areas: RNA-seq, ChIP-seq, microarray, exome-seq, mutation analyses, meta-analyses, motif analyses, pathway analyses, heatmap and gene clustering.

Interested candidates are invited to send a cover letter stating your research goals, curriculum vitae, and the contact details of two references to Wai Leong TAM. The lab is funded by the Singapore National Research Foundation, National Medical Research Council, A*STAR and Cancer Science Institute of Singapore.

Dr Tam Wai Leong
Principal Investigator
Email: tamwl[at]gis.a-star.edu.sg.
Click here for more information

Postdoctoral Fellow – Peter Lobie Lab

A postdoctoral position is available immediately for highly motivated Ph.D. graduates with background in molecular or cellular biology, biochemistry or other related fields who are interested in deciphering functions of secreted proteins in the context of cancer. The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, mentor students, and compete for fellowships.

 Qualifications:

  • A Ph.D. in cancer biology or related area
  • Expertise in DNA and protein biology (including work on secreted proteins and transcription factors) is preferred
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
  • Any experience with cloning, animal modelling, analyses of human clinical samples, is highly desirable
  • A proven track record in the form of publications in international English language journals
  • Ability to communicate in written and spoken English

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience and a brief paragraph on why you want to join the Lobie lab.

Prof Peter Lobie
Senior Principal Investigator, CSI Singapore
Email: csipel[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow – Yvonne Tay Lab

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

     Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow – Edward Chow Lab

A Postdoctoral Research Fellow position is available in the laboratory which focuses on a multidisciplinary approach towards improving cancer therapy development through the combination of engineering-based platforms and molecular biology studies.

We are seeking Ph.D. graduates with backgrounds in molecular biology, cancer biology and other related fields to work with preclinical mouse models of liver cancer, including patient-derived xenografts (PDXs), to investigate molecular mechanisms of cancer stem cell-related radioresistance as well as therapeutic strategies to overcome radioresistance. Furthermore, this work also will involve using PDXs to develop and evaluate platforms for personalized optimized drug combination design.

Candidates should be highly motivated, independent researchers who are able to design, implement and troubleshoot their own research plans. They should have previous experience with mouse models of cancer, molecular biology and cancer drug response evaluation. Successful candidates will have a proven track record of publication in relevant top-tier research journals.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief paragraph on why you want to join the Chow lab.

Dr. Edward Kai-Hua Chow, PhD
Principal Investigator, CSI Singapore
Email: csikce[at]nus.edu.sg

Postdoctoral Fellow – Yong Wei Peng Lab

A postdoctoral position is available immediately for MD and/or Ph.D. fellows. This candidate must have the ability to work independently and design and interpret experiments is essential, together with excellent organizational skills and fluency in English. He/she will be encouraged to present data at internal and external meetings and publish in peer-reviewed journals.

The successful candidate is expected to work with animal models of cancer, a prior experience is desirable although not necessary. Any previous experience in mentoring of junior staff is advantageous as the candidate will be actively involved in supporting graduate students and research assistants with their projects.

Candidates must have a proven track record in research and laboratory work in the form of publications in top English language journals. Ability to communicate in written and spoken English required. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief description of intent of research in the form of two proposals of what you would do in the laboratory.

Dr Yong Wei Peng
Principal Associate, CSI Singapore
Email: wei_peng_yong[at]nuhs.edu.sg

Postdoctoral Fellow – Alan Prem Kumar Lab

A Postdoctoral Research Fellow position is available in the laboratory which focuses on a multidisciplinary approach towards improving cancer therapy development.

We are seeking Ph.D. graduates with backgrounds in molecular biology, breast cancer biology and other related fields to work with preclinical mouse models of breast cancer, including patient-derived xenografts (PDXs), to investigate molecular mechanisms of cancer and cancer stem cell-related resistance as well as therapeutic strategies to overcome resistance. Furthermore, this work also will involve using PDXs to develop and evaluate platforms for personalized optimized drug combination design.

Candidates should be highly motivated, independent researchers who are able to design, implement and troubleshoot their own research plans. They should have previous experience with mouse models of cancer, molecular biology and breast cancer biology. Successful candidates will have a proven track record of publication in top-tier research journals.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience.

Dr. Alan Prem Kumar, PhD
Principal Associate, CSI Singapore
Email: csiapk[at]nus.edu.sg

Research Fellow (Bioinformatics) – Dr Dennis Kappei

We are seeking a highly motivated candidate as a Research Fellow in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The Research Fellow will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.

Requirements:

  • PhD in life sciences, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently
  • Preference will be given to candidates with
    • Experience with data analysis of proteomics and/or genomics data sets
    • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Dennis Kappei
Special Fellow, CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Click here for more info.

Research Associate – A/Prof Lee Soo Chin

To provide pathology-related input to enhance translational research in the Experimental Therapeutics Program, focusing on solid tumors (breast cancer, nasopharyngeal cancer)

Duties & Responsibilities

  1. Research Support
  2. Analysis of morphological features of clinical samples to be used for research
  3. Scoring of histological stains (IHC, ISH, FISH) in research projects
  4. Management and provision of pathology-related technologies
  5. Development and optimization of immunohistochemistry assays
  6. Tissue arrays
  7. Laser microdissection
  8. Autostainer
  9. Slide imaging systems
  10. Advanced microscopy systems
  11. Supervision and teaching of junior staff
  12. Leadership of pathology-based projects
  13. Assistance in the compilation of manuscripts and grants

Requirements

  • MBBS or MD
  • Preference will be given to candidates with
    • Several years of experience as a diagnostic histopathologist/surgical pathologist
    • Hands-on experience in immunohistochemistry, laser capture microdissection, construction of tissue microarrays, or diagnostic molecular biology techniques and technologies
  • Possess a very good understanding of the pathological processes of disease at a tissue level
  • Ability to work independently
  • Ability to communicate in written and spoken English
  • Excellent writing and reporting ability
  • Excellent communication skills and collaborative attitude to working in a multidisciplinary environment

Applications should include full curriculum vitae and the names, addresses and contact numbers of 3 professional references. Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment[at]nus.edu.sg
Website: www.csi.nus.edu.sg

Research Assistant - Takaomi Sanda Lab

A full-time Research Assistant position will be available after June 2017.

Job Scope:

  1. Research (work with PI and Research Fellows)
    1. Drug Screening
      • to perform a high-throughput drug screening with a small-molecule library using cell culture system
      • to perform validation experiments including cell culture, qRT-PCR and Westernblot.
    2. Mouse study
      • to establish and maintain mouse knockout models
      • to establish and maintain mouse xenograft models
      • to isolate tissues from the mice and to harvest cells, protein, RNA or DNA
      • to test therapeutic drugs in mouse models
  2. Administrative duties (work with PI and other Research Assistants)
    • to liaise with the core facilities, the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies
    • to maintain a systematic and proper record of all animals
    • to assist the Principal Investigator to review and update animals protocols
    • to be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project
    • to create and review standard operating procedures
  3. Laboratory:
    • to plan and ensure the needs and requirements of the team in terms of consumables
    • to assemble reagents, chemicals and media that are needed for experiments
    • to ensure that standard operating procedures and safety regulations are followed
    • responsible for the general cleanliness of the lab and core facility

Requirements:

  • University degree (Biology, Biomedical Science, Biotechnology)
  • Ability to speak and write well in English
  • Prior experience working with drug testing and/or animal models strongly preferred
  • Knowledge of:
    1.  basic principles and practices in the fields of biology
    2. principles, techniques and terminology used in biology
    3. principles, techniques and terminology used in animal studies
  • Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint

Dr Takaomi Sanda, MD, PhD
Principal Investigator, CSI Singapore
Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine
Email: csi_recruitment[at]nus.edu.sg
Click here for more information

Research Assistant - Sudhakar Jha Lab

A research assistant position is available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to transformation of cells form a normal to cancerous state.

The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.

Experience in epigenetics is highly preferred. Committed, hard-working and motivated candidates with BSc are welcome to apply. Applications should include full curriculum vitae and bibliography, summary of past accomplishments, and the names and email addresses of three references. Please send applications to:

Dr Sudhakar JHA, PhD
Principal Investigator, CSI Singapore
Email: csisjha[at]nus.edu.sg
Click here for more info.

Research Assistant - Alan Prem Kumar Lab

A Research Assistant position is available. Candidate must have a good background in molecular or cellular biology, biochemistry or who are interested in deciphering Hippo signaling in the context of cancer and cancer stem cells. The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, mentor students, and compete for fellowships.

Candidates with expertise in Hippo signaling and RNA biology with strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR, microRNA, isolation of cancer stem cells,  western blotting, immunoprecipitation, immunohistochemistry is preferred. Any experience with animal work, analyses of human clinical samples, RNA sequencing and/or RNA immunoprecipitation is highly desirable. Applicant should have a proven track record in the form of publication(s) in top international English language journals with the ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 2-3 referees. Please also include a summary of your research experience and a brief paragraph on why you want to join Dr Alan Prem Kumar’s group.

Dr Alan Prem Kumar
Principal Associate, CSI Singapore
Email: csi_recruitment[at]nus.edu.sg

Research Assistant - Toshio Suda Lab

A research assistant position is available. Candidate must have a good background in molecular or cellular biology, biochemistry or who are interested in deciphering DNA damage response (DDR) in the context of cancer and cancer stem cells.  The successful candidate will help to design experiments, conduct experiments, analyse data, and provide support to the Principal Investigator and his team.

Candidates with expertise in DDR with strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR, isolation of cells, western blotting, immunoprecipitation, immunohistochemistry is preferred. Candidates with experience in laboratory management is also highly desirable.

Motivated and hardworking candidates with BSc and ability to communicate in written and spoken English are welcome to apply. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees.

Please send applications to:
Prof Toshio Suda
Senior Principal Investigator, CSI
Email: csits[at]nus.edu.sg