Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Positions Available – Touati Benoukraf Lab

1. Postdoctoral Fellow

A postdoctoral position is available immediately for Ph.D and/or M.D graduates with strong backgrounds in cancer biology.

The successful candidate will be expected to design experiments, conduct experiments, analyse data, write papers and grants, mentor students and compete for fellowships. Candidates are required to have an understanding of molecular biology and cell biology and years of experience in research and laboratory work.

2. Research Assistant

A Research Assistant position is available immediately for Master degree holder in computational biology with experience in epigenomics studies (particularly in DNA methylation). The focus of the lab is on the role of transcription factors in epigenetic modulations and their effect in cell differentiation and cancer development. Candidates should have a solid background in bioinformatics, (epi)genomics, computer science and statistics.

The successful candidate will analyze and integrate in-house and publicly available (epi)genomic data sets (ChIP-seq, BS-seq, 450k illumina microarrays, RIP-seq and RNA-seq). The candidate is required to have a strong quantitative and statistics background, as well as strong programming skills in Python and R along with excellent skills in handling and understanding large (epi)genomic databases.

Applicants should have a proven track record in the form of publications in top international English language journals with the ability to communicate in written and spoken English. Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience and a brief paragraph on why you want to join the Benoukraf lab.

Dr Touati Benoukraf
Research Assistant Professor
CSI Singapore
Email: benoukraf[at]nus.edu.sg
Click here for more info

Positions Available - Melissa Fullwood Lab

1. Research Fellow

A full-time postdoctoral position is available for a Ph.D. graduate in the Fullwood Lab. The focus of the lab is on understanding chromatin interactions in cancer.

We are seeking highly motivated Ph.D. graduates with backgrounds in biological sciences, genomics, or other related fields who are interested in using a variety of methods to interrogate chromatin interactions in cancer, working with human cell lines, mouse models and clinical samples.

The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, and compete for fellowships. Candidates are required to have an understanding of imaging, mouse models, molecular biology and cell biology, a proven track record in the form of publications in top English language journals, and the ability to communicate in written and spoken English. Candidates must be willing to work with mouse models and clinical samples. Any experience in bioinformatics and epigenomics will be valued.

2.Research Assistant

A full-time Research Assistant position is available.

The focus of the lab is on understanding chromatin interactions in cancer.

We are seeking highly motivated Honours’ degree holders with intention to pursue Ph.D.  Candidates with backgrounds in biological sciences or related fields who are interested in doing research into epigenomics are invited to apply.  Candidates should be comfortable working independently and with other team members and be willing to work flexible schedules to manage workload on weekend or before/after normal working hours. Candidates are required to have an understanding of molecular biology and cell biology (any experience with bioinformatics is a plus) and the ability to communicate in written and spoken English, and present research findings in group meetings. Fresh graduates with honors/final year project experience are welcome to apply.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief paragraph on why you want to join the Fullwood lab.

Dr Melissa J. Fullwood, PhD
Principal Investigator, CSI Singapore
Email: melissa.fullwood[at]nus.edu.sg
Click here for more info.

Positions Available – Yoshiaki Ito Lab

1. Postdoctoral Fellow (Mechanism of Cancer Development)

A postdoctoral position is available immediately in Prof. Yoshiaki Ito’s lab. The group explores the multiple layers of tumor suppressor mechanisms that defend against tumor initiation as well as progression to late malignancy. Using mouse models, organoid cultures and molecular biology techniques, we trace the pathogenesis of cancer from stem cells, to precancerous adenomas, and finally to full-blown adenocarcinoma (Gastroenterology 152: 218-231, 2017).  We investigate how oncogenic stress response mechanisms, DNA repair networks (Cell Reports 8:767-782, 2014) and mitosis (PNAS 113:6490-6495, 2016) crosstalk with master regulators of cellular transcriptional programs to protect against carcinogenic insults in gastric (Gastroenterology 140:1536-1546, 2011), lung (Cancer Cell 24:603-616, 2013), colon (Cancer Cell 14:226-237, 2008) and breast cancer cells.

The successful candidate will focus on the investigation of molecular and clinical roles of RUNX in DNA repair mechanisms including the Fanconi anemia pathway. The group found that RUNX1 and RUNX3 interact with Fanconi anemia pathway proteins FANCD2 and FANCI to recruit them to the site of repair (Cell Reports 8:767-782, 2014). These novel roles of RUNX proteins are not related to transcription regulation, and are equally important in solid tumors including gastric cancer. The absence of RUNX function is also associated with a defective Fanconi-BRCA pathway and hypersensitivity to PARP inhibitors. Moving forward, the group aims to investigate the activity of RUNX in conjunction with these inhibitors, which will provide insights into their effective drug use in RUNX-deficient cancers.

Candidates should be PhD and/or MD PhD graduates with strong background in molecular biology, biochemistry and cell biology. Candidates with significant experience in the field of DNA damage repair, particularly on BRCA1, BRCA2, PARP inhibitors and Fanconi anemia, are highly preferred.

2. Postdoctoral Fellow (Gastric Cancer Immunity)
A postdoctoral position is available immediately in Prof. Yoshiaki Ito’s lab. The focus of the project is to investigate the molecular and clinical roles of newly identified cytokine compound driven by RUNX in gastric immunity.

Candidates should be PhD and/or MD PhD graduates with strong background in molecular biology, cell biology and immunology. Candidates with significant experience in the field of mucosal immunity, especially on T-cell polarization and flow cytometry experience are highly preferred

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees. Please also include a summary of your research experience and a brief description of intent of research in the form of two short proposals.

Please indicate clearly on your application the postdoctoral position you are applying for and send your application to:

Prof Yoshiaki Ito
Senior Principal Investigator, CSI
Email: csiccaq[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow Positions Available – Daniel G Tenen Lab

1. Postdoctoral Fellow (Molecular or Cell Biology)

A postdoctoral position is available immediately for MD and/or Ph.D. fellows interested in gene regulation and epigenetics in cancer and stem cell biology. Advantages of working in the Cancer Science Institute of Singapore include grants for senior postdoctoral fellows in order to assist them in the transition to junior faculty, the availability to recruit outstanding graduate students to their projects, and the opportunity to work with some excellent bioinformaticians and genomicists.

The main focus is the role of RNA in epigenetic regulation, particularly in hematopoiesis and leukemia. Examples are regulation of key transcription factors by RNAs, including long noncoding RNAs (Ebralidze et al, Genes Dev 22:2085, 2008), RNA editing in cancer (Chen et al, Nature Medicine 19:209, 2013), how RNAs modulate and can be utilized to alter epigenetics marks (Di Ruscio et al, Nature 503:371, 2013), and the role of epigenetic changes in development of the cancer phenotype (Amabile et al, Nat Commun. 6:709, 2015). But other projects involving gene regulation and cancer are ongoing as well. Candidates must have a proven track record in research and laboratory work in the form of publications in top English language journals. Ability to communicate in written and spoken English is required.

2. Postdoctoral Fellow (Bioinformatics)

Postdoctoral positions are available immediately for PhD with experience in Bioinformatics (computational genomics). The focus of the lab is on transcription factors and gene regulation, and their relationship to normal differentiation and cancer. Candidates should have backgrounds in bioinformatics, genomics, computer science, statistics, or other related fields. Those who are interested in computational genomics, particularly in analysis and integration of various genomics data, are encouraged to apply. The successful candidate will analyse and integrate in-house genomic (ChIP-seq, RIP-seq, exo-seq, RNA-seq, and microarray) data sets and also utilize publically available genomic/clinical data sets to identify novel biological patterns and regulatory mechanisms. Candidates are required to have a strong quantitative and statistics background, as well as strong programming skills (e.g. Python, Perl, C, C++, Java, R, or other related programming knowledge), and excellent skills in handling genomic databases.

Applications for both positions should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees. Please also include a summary of your research experience and a brief description of intent of research in the form of two short proposals.

Please indicate clearly on your application the postdoctoral position you are applying for and send your application to:

Prof Daniel G. Tenen
Senior Principal Investigator, CSI
Email: csi_careers[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow / Research Assistant – Tam Wai Leong Lab

Position for a Bioinformatician at the research officer or post-doctoral level is available immediately at Dr Tam’s lab . The laboratory is broadly interested in understanding the contributions of cancer stem cells to malignant cancer progression. We focus on dissecting the distinctive properties of cancer stem cells in various carcinomas, and exploit these traits as vulnerabilities towards the development of targeted cancer therapies. The candidate will engage in bridging the gap between bioinformatics and biology. He/she will work on cancer genomics, transcriptomics, epigenomics and metabolomics in partnership with a ‘wet lab’ postdoc.

Applicants should have relevant training in the field of computational biology and biomedical sciences. Prior experience as a bioinformatician is highly desirable. Candidates are expected to be highly motivated, creative, and strongly enthusiastic in addressing challenging problems in the field of cancer.

Requirements:

  • Bachelor’s degree or Ph.D. in Computational Science, Bioinformatics, or Computational Biology
  • Must have an interest in exploring the interface between biology, bioinformatics and computing
  • Track record of scientific achievement and demonstrated creative abilities
  • Experience in some these areas: RNA-seq, ChIP-seq, microarray, exome-seq, mutation analyses, meta-analyses, motif analyses, pathway analyses, heatmap and gene clustering.

Interested candidates are invited to send a cover letter stating your research goals, curriculum vitae, and the contact details of two references to Wai Leong TAM. The lab is funded by the Singapore National Research Foundation, National Medical Research Council, A*STAR and Cancer Science Institute of Singapore.

Dr Tam Wai Leong
Principal Investigator
Email: tamwl[at]gis.a-star.edu.sg.
Click here for more information

Postdoctoral Fellow – Peter Lobie Lab

A postdoctoral position is available immediately for highly motivated Ph.D. graduates with background in molecular or cellular biology, biochemistry or other related fields who are interested in deciphering functions of secreted proteins in the context of cancer. The successful candidate will help to design experiments, conduct experiments, analyse data, write papers, write grants, mentor students, and compete for fellowships.

 Qualifications:

  • A Ph.D. in cancer biology or related area
  • Expertise in DNA and protein biology (including work on secreted proteins and transcription factors) is preferred
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
  • Any experience with cloning, animal modelling, analyses of human clinical samples, is highly desirable
  • A proven track record in the form of publications in international English language journals
  • Ability to communicate in written and spoken English

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience and a brief paragraph on why you want to join the Lobie lab.

Prof Peter Lobie
Senior Principal Investigator, CSI Singapore
Email: csipel[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow – Teh Bin Tean Lab

A post-doctoral Research Fellow position is available in Cancer Science Institute of Singapore, Prof Teh Bin Tean’s lab.

Responsibilities

  • Elucidate the molecular mechanisms of cancer-related proteins
  • Translate the mechanistic findings into clinical applications, such as drug design

Job requirements

  • PhD in Biological Sciences or related discipline
  • Experience in protein biochemical and biophysical assays
  • Experience in cell biology techniques
  • Experience in animal work is a plus
  • Excellent in spoken and written English
  • Excellent publications track record

We welcome interested applicants to submit a full CV including a list of publications, a letter of motivation addressing the above criteria and contact details of two referees to:

Prof Teh Bin Tean
Senior Principal Investigator, CSI
Email: csinlml[at]nus.edu.sg
Click here for more info.

Postdoctoral Fellow – Yvonne Tay Lab

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

     Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Research Fellow (Bioinformatics) – Dr Dennis Kappei

We are seeking a highly motivated candidate as a Research Fellow in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The Research Fellow will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.

Requirements:

  • PhD in life sciences, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently
  • Preference will be given to candidates with
    • Experience with data analysis of proteomics and/or genomics data sets
    • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Dennis Kappei
Special Fellow, CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Click here for more info.

Research Assistant - Chng Wee Joo Lab

Our laboratory is involved in disease-based research on haematological malignancies particularly leukemia and multiple myeloma. In these disease, we are mainly interested in 2 areas: Genomics and pre-clinical testing of novel therapeutic agents. We use global genomics as a tool to understand disease biology, clinical prognosis, and biomarkers and therapeutic targets identification.

The candidate for the position will assist post-docs in their work and maintain the laboratory’s inventory of reagents, cell lines and clinical samples. In particular, the candidate will take charge of microarray workflow using the Affymetrix platform as well as miRNA profiling either using microarray or RT-PCR. In addition, the candidate will be in charge of processing and preparing patient’s bone marrow and blood samples for banking.

Background in genomics, molecular biology and flow cytometry is preferred. Committed, hard-working and motivated candidates with BSc are welcome to apply.

Interested applicants should submit a cover letter, supported with a detailed resume, areas of strengths and experiences, and names and addresses of at least THREE referees immediately to:

Prof Wee Joo Chng
Senior Principal Investigator
Email: mdccwj[at]nus.edu.sg
Click here for more info.

Research Assistant - Takaomi Sanda Lab

A full-time Research Assistant position will be available after June 2017.

Job Scope:

  1. Research (work with PI and Research Fellows)
    1. Drug Screening
      • to perform a high-throughput drug screening with a small-molecule library using cell culture system
      • to perform validation experiments including cell culture, qRT-PCR and Westernblot.
    2. Mouse study
      • to establish and maintain mouse knockout models
      • to establish and maintain mouse xenograft models
      • to isolate tissues from the mice and to harvest cells, protein, RNA or DNA
      • to test therapeutic drugs in mouse models
  2. Administrative duties (work with PI and other Research Assistants)
    • to liaise with the core facilities, the vendors and the administrative office to ensure proper purchase requisitions, goods delivery and prompt payment of supplies
    • to maintain a systematic and proper record of all animals
    • to assist the Principal Investigator to review and update animals protocols
    • to be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project
    • to create and review standard operating procedures
  3. Laboratory:
    • to plan and ensure the needs and requirements of the team in terms of consumables
    • to assemble reagents, chemicals and media that are needed for experiments
    • to ensure that standard operating procedures and safety regulations are followed
    • responsible for the general cleanliness of the lab and core facility

Requirements:

  • University degree (Biology, Biomedical Science, Biotechnology)
  • Ability to speak and write well in English
  • Prior experience working with drug testing and/or animal models strongly preferred
  • Knowledge of:
    1.  basic principles and practices in the fields of biology
    2. principles, techniques and terminology used in biology
    3. principles, techniques and terminology used in animal studies
  • Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint

Dr Takaomi Sanda, MD, PhD
Principal Investigator, CSI Singapore
Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine
Email: csitakao[at]nus.edu.sg
Click here for more information