Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Research Assistant – Prof H. Phillip Koeffer

The position of Research Assistant is immediately available in the laboratory of Prof H. Phillip Koeffer to identify key DNA abnormalities in cancers and translating these findings into novel classifications and diagnoses.

Duties and Responsibilities:

–       Research

  • Responsible for maintenance/management of laboratory mouse colony
  • Plan and perform different mouse breeding schemes
  • Assist in carrying out animal experiments and downstream analysis with supervisors
  • Document and present the experimental results in a logical manner
  • Analyze and troubleshoot experimental results
  • Engage in exchange of ideas with team members and collaborators
  • Mentor attachment students in experiments and project design

–       Laboratory:

  • Responsible for the cleanliness and maintenance of equipment through regular checks
  • Ensure that the lab is adequately stocked with clean glassware, minor equipment chemicals, etc. required for experiments
  • Ensure compliance with standard operating procedures and safety regulations
  • Required to prepare reagents, chemicals and media for experiments
  • Coordinate lab meetings and with various academic institutions to organize joint youth academic seminars
  • Liaise with equipment companies and initiate resolutions for equipment/sequencing issues
  • Engage and grow relationships with collaborators and industrial partners to promote academic forums

–       Any other duties as required

Requirements:

  • Degree in Life Sciences or its equivalent. Fresh graduates are welcome to apply
  • Must have prior experience in animal (mouse) handling, animal modeling build, animal genotyping, next – generation sequencing, ChIP- sequencing, RNA – sequencing, ATAC- sequencing, 3/4C, CO –IP, GST-pull down, Mass spectrometry and bioinformatics are highly preferred
  • Knowledge of IACUC regulations is an added advantage
  • Background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, PCR, IHC, IF, real-time PCR and Western blotting
  • Proficient in MS Office Applications. Familiar with different biology analysis software, such as primer premier, Photoshop, graphpad and SPSS.
  • Highly-motivated individual with an inquisitive mind and have strong analytical, technical and problem solving skills
  • Excellent command of English
  • Team-player with good communication skills

Applications should include full curriculum vitae, publication list, and 2-3 reference letters. Please also include single page cover letter summarising your research experience, programmatic expertise, and why this position is of interest to you.
Email: csilelg[at]nus.edu.sg

Research Assistant (Bioinformatics & Software Development) – Jason Pitt Lab

The position of Research Assistant is immediately available in the laboratory of Dr Jason Pitt, which integrates cutting-edge data science techniques with biological expertise to facilitate novel discoveries in cancer genomics. Working closely with Dr Pitt, the shortlisted candidate will:

1)      Develop software solutions that allow cancer researchers to perform science at scale.
2)      Coordinate the aggregation, processing, and analysis of large genomic datasets.
3)      Document code and contribute to scientific manuscript writing.

Qualifications:

  • Bachelors’ or Masters’ in bioinformatics, computer science, genetics or related fields.
  • Strong Python programming skills and proficiency with Unix-based systems.
  • Working knowledge of databases (SQL, MySQL, noSQL, etc.) is an added advantage.
  • Experience analysing high-throughput biological data, particularly DNA sequencing is preferred.
  • Familiarity with high-performance and/or cloud computing is an added advantage.
  • Basic understanding of statistical inference.
  • Excellent written and spoken English.

Applications should include full curriculum vitae, publication list, and 2-3 reference letters. Please also include single page cover letter summarising your research experience, programmatic expertise, and why this position is of interest to you.

Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg

Postdoctoral Fellow – Yvonne Tay Lab

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow / Research Assistant – Tam Wai Leong Lab

Position for a Bioinformatician at the research officer or post-doctoral level is available immediately at Dr Tam’s lab . The laboratory is broadly interested in understanding the contributions of cancer stem cells to malignant cancer progression. We focus on dissecting the distinctive properties of cancer stem cells in various carcinomas, and exploit these traits as vulnerabilities towards the development of targeted cancer therapies. The candidate will engage in bridging the gap between bioinformatics and biology. He/she will work on cancer genomics, transcriptomics, epigenomics and metabolomics in partnership with a ‘wet lab’ postdoc.

Applicants should have relevant training in the field of computational biology and biomedical sciences. Prior experience as a bioinformatician is highly desirable. Candidates are expected to be highly motivated, creative, and strongly enthusiastic in addressing challenging problems in the field of cancer.

Requirements:

  • Bachelor’s degree or Ph.D. in Computational Science, Bioinformatics, or Computational Biology
  • Must have an interest in exploring the interface between biology, bioinformatics and computing
  • Track record of scientific achievement and demonstrated creative abilities
  • Experience in some these areas: RNA-seq, ChIP-seq, microarray, exome-seq, mutation analyses, meta-analyses, motif analyses, pathway analyses, heatmap and gene clustering.

Interested candidates are invited to send a cover letter stating your research goals, curriculum vitae, and the contact details of two references to Wai Leong TAM. The lab is funded by the Singapore National Research Foundation, National Medical Research Council, A*STAR and Cancer Science Institute of Singapore.

Dr Tam Wai Leong
Principal Investigator
Email: tamwl[at]gis.a-star.edu.sg.
Click here for more information

Research Assistant - Dr Anand D Jeyasekharan

A research assistant position is available immediately in Dr Anand Jeyasekharan’s lab at the Cancer Science Institute of Singapore, for a motivated scientist interested in developing novel biomarkers to guide the choice of chemotherapy and immunotherapy in cancer.

The successful candidate will be expected to plan and conduct experiments, contribute to lab upkeep/ management, and engage in multidisciplinary collaborative work.

Requirements:

  • Degree in Biology (Cellular/Molecular biology/ Genetics/ Biochemistry)
  • Candidates with knowledge and proficiency in immunohistochemistry and microscopy will be favoured.
  • Proficiency in basic molecular and cellular biology techniques such as cell culture, viability assays, cloning, real-time PCR and western blotting is required.
  • Ability to communicate fluently in written and spoken English is essential.

Applications should include full curriculum vitae, publication list, and 2 reference letters. Please also include single page summary of your research experience and why this position is of interest to you.

Dr. Anand D Jeyasekharan
Principal Investigator, CSI
Email: adj.recruitment[at]gmail.com
Click here for more info.