Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Research Assistant – Prof H. Phillip Koeffer

The position of Research Assistant is immediately available in the laboratory of Prof H. Phillip Koeffer to identify key DNA abnormalities in cancers and translating these findings into novel classifications and diagnoses.

Duties and Responsibilities:

–       Research

  • Responsible for maintenance/management of laboratory mouse colony
  • Plan and perform different mouse breeding schemes
  • Assist in carrying out animal experiments and downstream analysis with supervisors
  • Document and present the experimental results in a logical manner
  • Analyze and troubleshoot experimental results
  • Engage in exchange of ideas with team members and collaborators
  • Mentor attachment students in experiments and project design

–       Laboratory:

  • Responsible for the cleanliness and maintenance of equipment through regular checks
  • Ensure that the lab is adequately stocked with clean glassware, minor equipment chemicals, etc. required for experiments
  • Ensure compliance with standard operating procedures and safety regulations
  • Required to prepare reagents, chemicals and media for experiments
  • Coordinate lab meetings and with various academic institutions to organize joint youth academic seminars
  • Liaise with equipment companies and initiate resolutions for equipment/sequencing issues
  • Engage and grow relationships with collaborators and industrial partners to promote academic forums

–       Any other duties as required

Requirements:

  • Degree in Life Sciences or its equivalent. Fresh graduates are welcome to apply
  • Must have prior experience in animal (mouse) handling, animal modeling build, animal genotyping, next – generation sequencing, ChIP- sequencing, RNA – sequencing, ATAC- sequencing, 3/4C, CO –IP, GST-pull down, Mass spectrometry and bioinformatics are highly preferred
  • Knowledge of IACUC regulations is an added advantage
  • Background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, PCR, IHC, IF, real-time PCR and Western blotting
  • Proficient in MS Office Applications. Familiar with different biology analysis software, such as primer premier, Photoshop, graphpad and SPSS.
  • Highly-motivated individual with an inquisitive mind and have strong analytical, technical and problem solving skills
  • Excellent command of English
  • Team-player with good communication skills

Applications should include full curriculum vitae, publication list, and 2-3 reference letters. Please also include single page cover letter summarising your research experience, programmatic expertise, and why this position is of interest to you.
Email: csilelg[at]nus.edu.sg

Research Assistant (RNA Biology in Cancer) – Yvonne Tay Lab

A research assistant position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Honours’ degree holder with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data and write papers.

The Tay lab is in the Cancer Science Institute of Singapore, a state-of-the-art research center with a multifaceted and coordinated approach to cancer research, extending from basic cancer studies all the way to experimental therapeutics. The focus of the institute is on cancers endemic to Asian populations such as gastric, liver, lung, leukemia and breast cancers. The institute houses a full spectrum of research and clinical translational facilities. This major center is led by a team of world-class scientists with significant government funding from Singapore’s National Research Foundation and Ministry of Education.

Qualifications:

  • A Bachelor’s degree in a life science-related field
  • Experience with in vivo animal models, particularly mice and/or zebrafish
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable
  • Ability to communicate in written and spoken English

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Research Assistant – Dr Jobichen Chacko

The National University of Singapore invites applications for Research Assistant in the “RNA-biology project” under the Cancer Science Institute of Singapore (CSI). The project involves the structural and functional studies on RNA-methyl transferase interactions.

This is a joint appointment with CSI Singapore and Department of Biological Sciences, National University of Singapore.

Requirements:

  • Degree in life sciences, biochemistry, molecular biology, cell biology or other fields related/relevant to the position.
  • Prior experience in protein expression and purification.
  • Be able to work independently and in a team, have an investigative nature, attention to detail;

Applications should include full curriculum vitae (including personal particulars, academic and employment history, current/expected salary), complete list of publications/oral presentations and contact information of 2 referees

Dr. Jobichen Chacko
Associate Member
Email: jobichenc[at]nus.edu.sg

Research Assistant/Research Fellow (Bioinformatics) – Takaomi Sanda Lab

A full-time Research Fellow or Research Assistant position will be available after mid-August 2018. The primary focus of our laboratory is to understand the mechanism of transformation by aberrant activation of oncogenic transcription factors in acute leukemia through combining cancer genomics with functional genetics and bioinformatics. We also study non-coding RNAs and post-transcriptional mechanisms. Our long-term goal is to develop novel therapeutics targeting oncogenic pathways in cancer.

We are seeking highly motivated graduates. The candidate will analyze large scale genomic and transcriptomic data from next generation sequencing (whole genome sequencing, ChIP-seq, RNA-seq, Hi-C, 4C, etc), to study genomic abnormalities and transcriptional regulatory mechanisms in leukemia and normal hematopoietic cells. Candidates that are interested to work with leukemia biology are highly encouraged to apply.

Candidates should have a Bachelor’s degree (for Research Assistant position) or PhD degree (for Research Fellow position) in bioinformatics, biostatistics, computational biology, computer science or related fields. Knowledge for optimization and statistical packages and programming (e.g., Python, Perl, C, C++, Java, R, or other related programming knowledge) as well as the ability to work in a Linux environment are required. Research Fellow candidates should have experience in one or more of the following areas: 1) genome sequence analysis, 2) transcriptome analysis, 3) molecular modeling and simulation of biological systems.

The ability to work independently and design and interpret experiments is essential, together with excellent organizational skills and fluency in English. We are looking for a team- and goal-oriented personality who wants to work in a young and international team. Research Assistant and Research Fellow will be encouraged to present data at internal and external meetings and publish in peer-reviewed journals.

Applications should include full curriculum vitae, publication list, information on years of experience in research work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief paragraph on why you want to join the Sanda laboratory.

Please note that only shortlisted candidates will be contacted.

Dr Takaomi Sanda
Principal Investigator
Email: csitakao[at]nus.edu.sg
Click here for more info

Research Assistant (Bioinformatics & Software Development) – Jason Pitt Lab

The position of Research Assistant is immediately available in the laboratory of Dr Jason Pitt, which integrates cutting-edge data science techniques with biological expertise to facilitate novel discoveries in cancer genomics. Working closely with Dr Pitt, the shortlisted candidate will:

1)      Develop software solutions that allow cancer researchers to perform science at scale.
2)      Coordinate the aggregation, processing, and analysis of large genomic datasets.
3)      Document code and contribute to scientific manuscript writing.

Qualifications:

  • Bachelors’ or Masters’ in bioinformatics, computer science, genetics or related fields.
  • Strong Python programming skills and proficiency with Unix-based systems.
  • Working knowledge of databases (SQL, MySQL, noSQL, etc.) is an added advantage.
  • Experience analysing high-throughput biological data, particularly DNA sequencing is preferred.
  • Familiarity with high-performance and/or cloud computing is an added advantage.
  • Basic understanding of statistical inference.
  • Excellent written and spoken English.

Applications should include full curriculum vitae, publication list, and 2-3 reference letters. Please also include single page cover letter summarising your research experience, programmatic expertise, and why this position is of interest to you.

Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg

Research Associate - Bioinformatics Analyst

The position of Research Associate – jointly mentored by Drs. NG Siok Bian (NUHS & CSI) and Jason PITT (CSI) – is available immediately. Dr. Ng’s laboratory characterizes the molecular and pathological properties of EBV-associated lymphomas while the laboratory of Dr. Pitt applies data science techniques to identify critical features of cancer genomes. Working closely with both laboratories, the short-listed candidate will:

  1. Use high-throughput genomics data (e.g., WGS, WXS & RNA-seq) to elucidate the pathogenesis EBV-associated lymphomas.
  2. Coordinate the aggregation and harmonization of publicly available genomics datasets.
  3. Independently plan, analyze and interpret computational experiments.
  4. Document code and contribute to scientific manuscript writing.

Required qualifications:

  • Masters degree (at minimum) in bioinformatics, genetics, computer science or a related field.
  • Experience analysing high-throughput biological datasets, particularly DNA/RNA sequencing and microarray data.
  • Python programming skills and proficiency with Unix-based systems.
  • Understanding of and experience with statistical inference.
  • Excellent written and spoken English.

Preferred qualifications:

  • Familiarity with distributed computing systems (cluster, high-performance, and/or cloud computing).
  • Working knowledge of databases (SQL, MySQL, etc.).

Applications should include full curriculum vitae, publication list, and 2-3 reference letters. Please also include single page cover letter summarizing your research experience, programmatic expertise, and why this position is of interest to you.

Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg

Research Fellow – Sudhakar Jha Lab

A research fellow position is available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to transformation of cells form a normal to cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.

Requirements:

  • PhD in cancer biology or related area.
    4-5 years of experience in the field of Epigenetics and Breast Cancer is preferred.
  • Applications should include curriculum vitae and bibliography, summary of past accomplishments, and the names and email addresses of three references.

Dr Sudhakar Jha
Principal Investigator
Email: csisjha[at]nus.edu.sg
Click here for more info

Research Assistant – Dr Sudhakar Jha

Two research assistant positions are available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to transformation of cells form a normal to cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.

Requirements:

  • Minimum qualification should be Bachelor of Science (B.Sc.) but Master of Science (M.Sc.) would be preferred

Applications, including curriculum vitae and bibliography, summary of past accomplishments, and the names and email addresses of three references should be sent by e-mail to:

Dr Sudhakar Jha
Principal Investigator
Email: csisjha[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow – Yvonne Tay Lab

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow / Research Assistant – Tam Wai Leong Lab

Position for a Bioinformatician at the research officer or post-doctoral level is available immediately at Dr Tam’s lab . The laboratory is broadly interested in understanding the contributions of cancer stem cells to malignant cancer progression. We focus on dissecting the distinctive properties of cancer stem cells in various carcinomas, and exploit these traits as vulnerabilities towards the development of targeted cancer therapies. The candidate will engage in bridging the gap between bioinformatics and biology. He/she will work on cancer genomics, transcriptomics, epigenomics and metabolomics in partnership with a ‘wet lab’ postdoc.

Applicants should have relevant training in the field of computational biology and biomedical sciences. Prior experience as a bioinformatician is highly desirable. Candidates are expected to be highly motivated, creative, and strongly enthusiastic in addressing challenging problems in the field of cancer.

Requirements:

  • Bachelor’s degree or Ph.D. in Computational Science, Bioinformatics, or Computational Biology
  • Must have an interest in exploring the interface between biology, bioinformatics and computing
  • Track record of scientific achievement and demonstrated creative abilities
  • Experience in some these areas: RNA-seq, ChIP-seq, microarray, exome-seq, mutation analyses, meta-analyses, motif analyses, pathway analyses, heatmap and gene clustering.

Interested candidates are invited to send a cover letter stating your research goals, curriculum vitae, and the contact details of two references to Wai Leong TAM. The lab is funded by the Singapore National Research Foundation, National Medical Research Council, A*STAR and Cancer Science Institute of Singapore.

Dr Tam Wai Leong
Principal Investigator
Email: tamwl[at]gis.a-star.edu.sg.
Click here for more information