Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Positions Available – Yvonne Tay Lab

1.Postdoctoral Fellow

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

2. Research Assistant (RNA Biology in Cancer)

A research assistant position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Honours’ degree holder with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data and write papers.

The Tay lab is in the Cancer Science Institute of Singapore, a state-of-the-art research center with a multifaceted and coordinated approach to cancer research, extending from basic cancer studies all the way to experimental therapeutics. The focus of the institute is on cancers endemic to Asian populations such as gastric, liver, lung, leukemia and breast cancers. The institute houses a full spectrum of research and clinical translational facilities. This major center is led by a team of world-class scientists with significant government funding from Singapore’s National Research Foundation and Ministry of Education.

Qualifications:

  • A Bachelor’s degree in a life science-related field
  • Experience with in vivo animal models, particularly mice and/or zebrafish
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable
  • Ability to communicate in written and spoken English

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info

Postdoctoral Fellow (Molecular or Cell Biology) – Daniel G Tenen Lab

A postdoctoral position is available immediately for MD and/or Ph.D. fellows interested in gene regulation and epigenetics in cancer and stem cell biology. Advantages of working in the Cancer Science Institute of Singapore include grants for senior postdoctoral fellows in order to assist them in the transition to junior faculty, the availability to recruit outstanding graduate students to their projects, and the opportunity to work with some excellent bioinformaticians and genomicists.

The main focus is the role of RNA in epigenetic regulation, particularly in hematopoiesis and leukemia. Examples are regulation of key transcription factors by RNAs, including long noncoding RNAs (Ebralidze et al, Genes Dev 22:2085, 2008), RNA editing in cancer (Chen et al, Nature Medicine 19:209, 2013), how RNAs modulate and can be utilized to alter epigenetics marks (Di Ruscio et al, Nature 503:371, 2013), and the role of epigenetic changes in development of the cancer phenotype (Amabile et al, Nat Commun. 6:709, 2015). But other projects involving gene regulation and cancer are ongoing as well. Candidates must have a proven track record in research and laboratory work in the form of publications in top English language journals. Ability to communicate in written and spoken English is required.

Applications for both positions should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees. Please also include a summary of your research experience and a brief description of intent of research in the form of two short proposals.

Please indicate clearly on your application the postdoctoral position you are applying for and send your application to:

Prof Daniel G. Tenen
Senior Principal Investigator, CSI
Email: csi_careers[at]nus.edu.sg
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Postdoctoral Fellow / Research Assistant – Tam Wai Leong Lab

Position for a Bioinformatician at the research officer or post-doctoral level is available immediately at Dr Tam’s lab . The laboratory is broadly interested in understanding the contributions of cancer stem cells to malignant cancer progression. We focus on dissecting the distinctive properties of cancer stem cells in various carcinomas, and exploit these traits as vulnerabilities towards the development of targeted cancer therapies. The candidate will engage in bridging the gap between bioinformatics and biology. He/she will work on cancer genomics, transcriptomics, epigenomics and metabolomics in partnership with a ‘wet lab’ postdoc.

Applicants should have relevant training in the field of computational biology and biomedical sciences. Prior experience as a bioinformatician is highly desirable. Candidates are expected to be highly motivated, creative, and strongly enthusiastic in addressing challenging problems in the field of cancer.

Requirements:

  • Bachelor’s degree or Ph.D. in Computational Science, Bioinformatics, or Computational Biology
  • Must have an interest in exploring the interface between biology, bioinformatics and computing
  • Track record of scientific achievement and demonstrated creative abilities
  • Experience in some these areas: RNA-seq, ChIP-seq, microarray, exome-seq, mutation analyses, meta-analyses, motif analyses, pathway analyses, heatmap and gene clustering.

Interested candidates are invited to send a cover letter stating your research goals, curriculum vitae, and the contact details of two references to Wai Leong TAM. The lab is funded by the Singapore National Research Foundation, National Medical Research Council, A*STAR and Cancer Science Institute of Singapore.

Dr Tam Wai Leong
Principal Investigator
Email: tamwl[at]gis.a-star.edu.sg.
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Postdoctoral Fellow – Yong Wei Peng Lab

A postdoctoral position is available immediately for MD and/or Ph.D. fellows. This candidate must have the ability to work independently and design and interpret experiments is essential, together with excellent organizational skills and fluency in English. He/she will be encouraged to present data at internal and external meetings and publish in peer-reviewed journals.

The successful candidate is expected to work with animal models of cancer, a prior experience is desirable although not necessary. Any previous experience in mentoring of junior staff is advantageous as the candidate will be actively involved in supporting graduate students and research assistants with their projects.

Candidates must have a proven track record in research and laboratory work in the form of publications in top English language journals. Ability to communicate in written and spoken English required. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 references. Please also include a summary of your research experience and a brief description of intent of research in the form of two proposals of what you would do in the laboratory.

Dr Yong Wei Peng
Principal Associate, CSI Singapore
Email: wei_peng_yong[at]nuhs.edu.sg

Postdoctoral Fellow – Alan Prem Kumar Lab

A Postdoctoral Research Fellow position is available in the laboratory which focuses on a multidisciplinary approach towards improving cancer therapy development.

We are seeking Ph.D. graduates with backgrounds in molecular biology, breast cancer biology and other related fields to work with preclinical mouse models of breast cancer, including patient-derived xenografts (PDXs), to investigate molecular mechanisms of cancer and cancer stem cell-related resistance as well as therapeutic strategies to overcome resistance. Furthermore, this work also will involve using PDXs to develop and evaluate platforms for personalized optimized drug combination design.

Candidates should be highly motivated, independent researchers who are able to design, implement and troubleshoot their own research plans. They should have previous experience with mouse models of cancer, molecular biology and breast cancer biology. Successful candidates will have a proven track record of publication in top-tier research journals.

Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (e-mail and telephone numbers) of 3 references. Please also include a summary of your research experience.

Dr. Alan Prem Kumar, PhD
Principal Associate, CSI Singapore
Email: csiapk[at]nus.edu.sg

Research Fellow (Bioinformatics) – Dr Dennis Kappei

We are seeking a highly motivated candidate as a Research Fellow in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The Research Fellow will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.

Requirements:

  • PhD in life sciences, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently
  • Preference will be given to candidates with
    • Experience with data analysis of proteomics and/or genomics data sets
    • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Dennis Kappei
Special Fellow, CSI Singapore
Email: dennis.kappei[at]nus.edu.sg
Click here for more info.

Research Associate – A/Prof Lee Soo Chin

To provide pathology-related input to enhance translational research in the Experimental Therapeutics Program, focusing on solid tumors (breast cancer, nasopharyngeal cancer)

Duties & Responsibilities

  1. Research Support
  2. Analysis of morphological features of clinical samples to be used for research
  3. Scoring of histological stains (IHC, ISH, FISH) in research projects
  4. Management and provision of pathology-related technologies
  5. Development and optimization of immunohistochemistry assays
  6. Tissue arrays
  7. Laser microdissection
  8. Autostainer
  9. Slide imaging systems
  10. Advanced microscopy systems
  11. Supervision and teaching of junior staff
  12. Leadership of pathology-based projects
  13. Assistance in the compilation of manuscripts and grants

Requirements

  • MBBS or MD
  • Preference will be given to candidates with
    • Several years of experience as a diagnostic histopathologist/surgical pathologist
    • Hands-on experience in immunohistochemistry, laser capture microdissection, construction of tissue microarrays, or diagnostic molecular biology techniques and technologies
  • Possess a very good understanding of the pathological processes of disease at a tissue level
  • Ability to work independently
  • Ability to communicate in written and spoken English
  • Excellent writing and reporting ability
  • Excellent communication skills and collaborative attitude to working in a multidisciplinary environment

Applications should include full curriculum vitae and the names, addresses and contact numbers of 3 professional references. Please send applications to:

Cancer Science Institute of Singapore
National University of Singapore Centre for Translational Medicine,
14 Medical Drive, #12-01,
Singapore 117599
Email: csi_recruitment[at]nus.edu.sg
Website: www.csi.nus.edu.sg

Research Assistant - Toshio Suda Lab

A research assistant position is available. Candidate must have a good background in molecular or cellular biology, biochemistry or who are interested in deciphering DNA damage response (DDR) in the context of cancer and cancer stem cells.  The successful candidate will help to design experiments, conduct experiments, analyse data, and provide support to the Principal Investigator and his team.

Candidates with expertise in DDR with strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR, isolation of cells, western blotting, immunoprecipitation, immunohistochemistry is preferred. Candidates with experience in laboratory management is also highly desirable.

Motivated and hardworking candidates with BSc and ability to communicate in written and spoken English are welcome to apply. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 3 referees.

Please send applications to:
Prof Toshio Suda
Senior Principal Investigator, CSI
Email: csits[at]nus.edu.sg

Research Assistant (Bioinformatician) - Phillip Koeffler Lab

We are seeking a bright, energetic individual with superior bioinformatics skill in order to interact with approximately 10-15 post-docs/Ph.D. students, each of them are doing massively parallel sequencing of various tumors, RNA-Seq, ChIP-Seq, RNA array as well as combing the bioinformatics literature for hot leads.

Requirements:

  • MSc/PhD in life sciences, bioinformatics, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently
  • Preference will be given to candidates with
    • Experience with data analysis of genomics and/or proteomics data sets
    • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Vikas Madan
Senior Research Scientist
Email: csivm[at]nus.edu.sg
Click here for more info.

Research Pathologist - A/Prof Ng Siok Bian

A/Prof Ng’s laboratory is involved in disease-based research on haematolymphoid malignancies particularly lymphoma. In this tumour, she is mainly interested in 2 areas: Genomics and pre-clinical testing of novel therapeutic agents and biomarkers. A/Prof Ng uses global genomics as a tool to understand disease biology, clinical prognosis, biomarkers and therapeutic targets identification.

The candidate for the current position will mainly work on the following projects:

  1. Paraffin tissue sectioning and staining
  2. Optimizing and performing immunohistochemistry (IHC) for novel biomarkers for validation of genomics data, including double IHC/In situ hybridization staining.
  3. Reading H&E histology slide and scoring of IHC protein expression in tissue sections.
  4. Construction of tissue microarrays
  5. Performing fluorescence in situ hybridization (FISH) on paraffin tissue sections

Applicants must be a certified anatomic pathologist or an M.D. with a background in anatomic pathology. Applicants must also have experience in performing and evaluating immunohistochemistry. Previous work experience in a clinical histopathology laboratory or paraffin tissue based related research work is preferred. PhD qualification is not necessary.

Opportunities to learn other basic and advance molecular biology techniques such as cell culture, western blot, qPCR, functional assays and/or gene expression profiling will be available if interest is shown.

Applicants should submit a cover letter, supported with a detailed resume, areas of strengths and experiences, and names and addresses of at least THREE referees immediately to: 

A/Prof S.B. Ng
Principal Associate, CSI Singapore
Email: patnsb[at]nus.edu.sg