Research

Research Positions Available 

Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.

Research Assistant – Dr. Sudhakar Jha Lab

Two research assistant positions are available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to the transformation of cells from a normal to a cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.

Requirements:
Candidates should have a BSc Degree with experience in the epigenetics and chromatin biology.

Applications, including curriculum vitae and bibliography, a summary of past accomplishments, and the names and email addresses of three references should be sent by e-mail to:

Dr Sudhakar Jha
Principal Investigator
Email: csisjha[at]nus.edu.sg
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Research Assistant (Bioinformatics/Quantitative Proteomics)

We are seeking a highly motivated candidate as a research assistant in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The research assistant will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.

Requirements:

  • Degree in life sciences, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently

Preference will be given to candidates with:

  • Experience with data analysis of proteomics and/or genomics data sets
  • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Dennis Kappei
Principal Investigator
Email: dennis.kappei[at]nus.edu.sg
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Research Fellow (Bioinformatics/Quantitative Proteomics)

We are seeking a highly motivated candidate as a research fellow in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The research fellow will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.

Requirements:

  • PhD in life sciences, biostatistics, computer science or related fields
  • Programming skills in Python, R or equivalent language
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English
  • Ability to solve problems independently

Preference will be given to candidates with:

  • Experience with data analysis of proteomics and/or genomics data sets
  • Working knowledge of basic molecular biology techniques

Applications should include in a single PDF a cover letter, curriculum vitae and the names and contact information of at least 2 professional references. Please send applications with the reference “Bioinformatics MS” to:

Dr. Dennis Kappei
Principal Investigator
Email: dennis.kappei[at]nus.edu.sg
Click here for more info

Deputy Head – Transgenic Core Facility

The Transgenic and Gene Targeting Facility (TGTF) is a joint operation between CSI and the Comparative Medicine (CM) animal facility at NUS. The Facility operates as a “business” where customer-service and project-management skills are paramount.

The Deputy Head of the Facility is responsible for oversight and to provide day to day management of the TCF on routine technologies such as embryo rederivation or cryo-conservation (embryo- and sperm freezing) as well as, on established and novel technologies enabling generation of new mouse models, including ES-cell injection, pronucleus injection (transgenic mouse models) and gene-editing via CRISPR/Cas9 (both on ES-cells and via electroporation into embryos).

Duties & Responsibilities:

  • Assist Facility Head in the day to day operations, pricing for services and budgeting of the Facility
  • Supervise the specialized and trained technicians, already working there, ensuring effective customer service and project management
  • Keep up to date with the latest technologies and advances relevant to the Facility
  • Responsible for effective marketing, advertising, and training to keep abreast of the research needs in order to encourage scientists to use the Facility
  • Oversee all routine and complex breeding of rodent colonies for the Facility
  • Partner with Principal Investigators to establish cohort needs, measuring progress and addressing all issues that arise
  • Guide scientists in designing new mouse models
  • Responsible to maintain an adequate number of animals by setting up breeding pairs, manage breeding rotations and setting up timed pregnancies.
  • Responsible for Facility’s weaning and identification of pups, and genotyping of each animal in order to generate homozygous or transgenic lines, and maintaining appropriate breeding schemes per strain
  • Observe rodents for obvious phenotype and perform a natural history analysis when necessary
  • Maintain detailed and accurate records (GLP and non-GLP) for all colonies and perform record audits as needed to ensure accuracy and maintain compliance
  • Perform as well as supervise Facility team in other technical research procedures (dosing, injections, sample collections, etc.) and husbandry activities as needed.
  • Participate in an occupational safety and health programs which may require tuberculin testing and potentially immunization
  • Weekend work, holiday work and overtime hours are a requirement of this position
  • Any other duties as assigned with respect to Facility needs

Requirements:

Applicants should be motivated, team-oriented and open-minded with a Ph.D. in life/biological sciences. In addition, the following qualifications are required:

  • Good skills and in-depth hands-on experience in molecular techniques related to cloning and genome editing via CRISPR/Cas9.
  • 3 to 5 years of relevant experience working with transgenic animal models or equivalent combination of education and experience required.
  • Must have experience handling rodents and other lab animals
  • Must have experience with rodent breeding programs and have a working knowledge of breeding, weaning, and record-keeping
  • GLP experience preferred
  • Excellent demonstrated accuracy, attention to detail and work ethic is a must!
  • Excellent oral and written communication skills, including demonstrated ability to communicate effectively with all levels of staff
  • Must have a demonstrated ability to foster positive relationships with co-workers and researchers
  • Must have a demonstrated ability to work independently, with minimal supervision.

Please send your CVs (including the names and email contacts of two or more references) to:

Cancer Science Institute of Singapore
National University of Singapore
Centre for Translational Medicine
14 Medical Drive #12-01
Singapore 117599

Email: csi_recruitment[at]nus.edu.sg

Research Fellow – Dr. Sudhakar Jha Lab

A postdoctoral position is available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to the transformation of cells from a normal to cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.

Requirements:
Candidates should have a PhD in cancer biology or related area and prior experience working with mouse.

Applications, including curriculum vitae and bibliography, summary of past accomplishments, and the names and email addresses of three references should be sent by e-mail to:

Dr Sudhakar Jha
Principal Investigator
Email: csisjha[at]nus.edu.sg
Click here for more info

Research Assistant/Associate (Software Engineer) – Dr. Jason Pitt Lab

The position of Research Assistant/Associate (software engineer) is immediately available in the laboratory of Dr. Jason Pitt, which integrates data science and biological expertize to facilitate novel discoveries in cancer genomics. The Pitt Laboratory achieves this by developing cutting-edge software that allows cost-effective identification, harmonization, and interrogation of large genomic datasets. Collectively, we refer to this domain as genome economics. Successful candidates will interact closely with the Data Science and Learning Division of Argonne National Laboratory (USA) as well as our industrial partners. This position provides a rare opportunity to utilize Amazon Web Services, Amazon Alexa, data-intensive computing, natural language processing, and artificial intelligence.

Responsibilities

Participate in the development of:

1) Melvin, a virtual genome analysis assistant using Amazon’s Alexa technology

  • Build upon a functional prototype
  • Design and implement optimal client/server solutions
  • Contribute to all stages of the software development life cycle

2) The Scalable Workflows for the Analysis of Genomes (Swag) framework

  • Optimize of bioinformatic tools for cost and accuracy
  • Facilitate large-scale analytics on HPC and commercial clouds

Requirements

  • Bachelors or Masters degree (minimally) in computer science, information systems, bioinformatics, engineering, mathematics, or related fields
  • Strong Python programming skills and proficiency with Unix-based systems
  • Working knowledge of databases (SQL, NoSQL, Elasticsearch, etc.)
  • Record of problem-solving and robust design skills
  • Excellent written and spoken English

Preferences

  • Basic knowledge of biology and genetics
  • Familiarity with Amazon Web Services
  • Interest in computational linguistics
  • Analytical and/or visualization experience with R

Applications should include full curriculum vitae, publication list (if applicable), and contact information for 2-3 referees. Please also include single page cover letter summarizing your experience, programmatic expertise, and why this position is of interest to you.

Dr. Jason J. Pitt
Special Fellow
Email: jason.j.pitt[at]nus.edu.sg
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Research Assistant – Prof. Toshio Suda Lab

A Research Assistant position is available immediately in Prof Toshio Suda’s lab at the Cancer Science Institute of Singapore, for a motivated scientist.

Duties and Responsibilities:

  • Assist primarily with cell culture and possibly, FACS experiments in the lab.
  • Genome analyses.

Requirements:

  • A Bachelor’s degree in Biology (Cellular/Molecular biology/ Genetics/ Biochemistry).
  • Prior experience in immunohistochemistry (IHC) staining is essential.
  • Proficiency in basic molecular and cellular biology techniques including cell culture, real-time PCR and western blotting.
  • Highly motivated individual with an inquisitive mind and have strong analytical, technical and problem-solving skills.
  • Excellent command of English.
  • Team player with good communication skills.

Applications should include full curriculum vitae (including personal particulars, academic and employment history, and current/expected salary), a complete list of publications/oral presentations and contact information of 2 referees.

Prof Toshio Suda
Principal Investigator
Email: csi_recruitment[at]nus.edu.sg
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Research Assistant/Laboratory Executive (Animal work) – Dr. Takaomi Sanda lab

A full-time Research Assistant/Laboratory Executive position will be available after February 2019. An applicant can choose either research track (Research Assistant) or executive track (Laboratory Executive).

Requirements:

  • University degree (biology, biomedical science, biotechnology or related area).
  • Ability to speak and write well in English.
  • Prior experience working with mouse or/and zebrafish model.
  • Knowledge of: 1) basic principles and practices in the fields of biology, 2) principles, techniques and terminology used in biology, 3) principles, techniques and terminology used in animal studies.
  • Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint.

Job scope:

a) Research: 40%

a.i) Animal study (mouse or zebrafish)

  • To maintain animal colonies including breeding.
  • To perform genotyping.
  • To create transgenic and knockout animal models, and perform xenograft studies.
  • To isolate tissues from the animal and analyze by flowcytometry.
  • To harvest cells, protein, RNA or DNA.

a.ii) Preparation of biological materials and perform experiments

  • To purify DNA, RNA or protein from cell lines or bacteria.
  • To perform experiments including cell culture, PCR, immunoprecipitation and Western blot.

b) Administrative duties: 40%

  • To maintain a systematic and proper record of animals, including annual reports.
  • To liaise with the core facilities, committees and the administrative office to assist in research.
  • To liaise with the vendors to ensure proper purchase requisitions, goods delivery and prompt payment of supplies.
  • To be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project.
  • To create and review standard operating procedures and risk assessments.

c) Laboratory: 20%

  • Responsible for the general cleanliness of the lab and core facility.
  • To assemble reagents, chemicals and media that are needed for experiments.
  • To ensure that standard operating procedures and safety regulations are followed.

Applications should include full curriculum vitae and 2-3 reference letters. Please note that only shortlisted candidates will be contacted.

Dr Takaomi Sanda
Principal Investigator
Email: csi_recruitment[at]nus.edu.sg
Click here for more info

Research Assistant (Bioinformatics) – Dr. Melissa Fullwood Lab

We are seeking a highly motivated candidate with intention to pursue a PhD as a Research Assistant (Bioinformatics) in the Fullwood Lab. Our research interest is to better understand the role of 3D genome organization in the control of RNA Biology in Cancer. Specifically, we are looking for a candidate who will analyse chromatin interaction data (e.g. Hi-C, ChIA-PET, 4C, etc), related data (e.g. ChIP-Seq, RNA-Seq), present data and write manuscripts. The candidate will also assist in routine data management e.g. management of servers, as required. Candidates should be comfortable in working independently and with other team members, learning new things on their own and be willing to work in flexible schedules to manage workload on weekend or before/after normal working hours.

Requirements:

  • Degree in computational biology or bioinformatics or related fields
  • Strong mathematical & statistics analytics background and strong programming skills (e.g. Python, R) and the ability to work in a Linux environment
  • Experience in chromatin interaction data analysis and/or genomic and epigenomic data analysis is not required but is a plus.
  • Excellent communication skills and good team spirit
  • Fluent in spoken and written English

Applications should include in a single PDF a cover letter, curriculum vitae, certificates of qualifications and the names and contact information of at least 3 professional references.

Dr Melissa Fullwood
Principal Investigator
Email: csimjf[at]nus.edu.sg
Click here for more info

Research Assistant - A/Prof Henry Yang

A full-time Research Assistant position is immediately available at the Bioinformatics Core, Cancer Science Institute of Singapore. The primary focus of our group is to analyze and integrate various genomic data for novel discoveries in cancer genomics. For this particular position, we are seeking highly motivated graduates who are interested in integration of human genomic data with microbiome data. The candidate will develop an integrative computational analysis platform for profiling interactions between human host and microbiome based on different genomics data.

Requirement:

Candidates should have a Bachelor’s degree in bioinformatics, computational biology or related fields. Knowledge and experience in genomics, genome sequence analysis, and transcriptome data analysis are required. Candidates should also have solid programming skills (e.g., Python, Perl, Java, R) as well as strong mathematical analytics background.

Applications should include full curriculum vitae and 2-3 reference letters. Please note that only shortlisted candidates will be contacted.

A/Prof Henry Yang
Head of Bioinformatics Core
Email: csiyangh[at]nus.edu.sg
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Postdoctoral Fellow – Dr. Yvonne Tay Lab

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

Qualifications:

  • A Ph.D. in cancer biology or related area.
  • Experience with in vivo animal models, particularly mice and/or zebrafish.
  • Expertise in RNA biology (including but not limited to microRNAs) is preferred.
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
  • Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
  • Ability to independently lead research projects and critically analyse data.
  • A proven track record in the form of publications in top international English language journals.
  • Ability to communicate in written and spoken English.

Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

Dr Yvonne Tay
Principal Investigator
Email: yvonnetay[at]nus.edu.sg
Click here for more info