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Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer. (Biomaterials, Jan 2018)

Fong ELS1, Toh TB2, Lin QXX2, Liu Z3, Hooi L2, Mohd Abdul Rashid MB2, Benoukraf T2, Chow EK4, Huynh TH5, Yu H6. 1 Department of Biomedical Engineering, National University of Singapore, Singapore. 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3 Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research

She looks into DNA for cancer ‘switch’ (Straits Times, Feb 2018)

Dr Melissa Fullwood, Principal Investigator at CSI Singapore, was featured on the Straits Times on 19 February 2018. In the article, she describes her enthusiasm for science since she was a child, and her current research work on cancer. Read about it here!

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. (Genes Dev, Jan 2018)

Leong WZ1, Tan SH1, Ngoc PCT11, Amanda S1, Yam AWY1, Liau WS1, Gong Z2, Lawton LN1, Tenen DG1,3,4, Sanda T1,4. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore. 2 Department of Biological Sciences, National University of Singapore, 117543 Singapore. 3 Harvard Medical School, Boston, Massachusetts 02215, USA. 4 Department

CSI Welcomes Delegation from TATA Memorial Centre, Mumbai

On 15 January, CSI hosted a visit from a delegation of five distinguished guests from TATA Memorial Centre, Mumbai. The TATA Memorial Centre is a specialist cancer treatment and research centre, closely associated with the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC). Senior management from the TATA Memorial Centre were at CSI

CSI Singapore Welcomes our New Graduate Students in RNA Biology!

New year, new semester – In January 2018, CSI warmly welcomed four new PhD students who joined our graduate program in RNA Biology. The PhD program, offered by the RNA Biology Center (RBC) at CSI Singapore, supports graduate students working in the field of RNA Biology and cancer. These students will undergo a rigorous five-year

Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β. (Mol Cancer Ther, Jan 2018)

Lau WM1, Teng E1, Huang KK1,2, Tan JW1, Das K2, Zang Z2, Chia T1, Teh M1, Kono K1,4, Yong WP1,5, Shabbir A4, Tay A4, Phua NS4, Tan P2,6, Chan SL6, So JBY4. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Cancer and Stem Cell Biology Program, Duke-NUS Medical School,

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling. (Cancer Lett, Jan 2018)

Wang L1, Syn NL2, Subhash VV3, Any Y4, Thuya WL3, Cheow E3, Kong L3, Yu F5, Peethala PC3, Wong AL2, Laljibhai HJ3, Chinnathambi A6, Ong PS7, Ho PC7, Sethi G8, Yong WP9, Goh BC10. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of

A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer. (Nucleic Acids Res, Dec 2017)

Chan JJ1, Kwok ZH1, Chew XH1, Zhang B1, Liu C2, Soong TW2,3, Yang H1, Tay Y1,4. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. 3 National Neuroscience Institute, Singapore 308433, Singapore.

TGFβ Promotes Genomic Instability after Loss of RUNX3. (Cancer Res, Jan 2018)

Krishnan V1, Chong YL2, Tan TZ2, Kulkarni M2,3, Bin Rahmat MB2, Tay LS2, Sankar H2, Jokhun DS4,5, Ganesan A2, Chuang LSH2, Voon DC2, Shivashankar GV4,5, Thiery JP6,7, Ito Y1. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3 Lee