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CSI Singapore Won Three Awards at the Scientific Frontiers in Natural Product Based Drugs 2017

Congratulations to our CSI Research Assistants, Ms Madhu Mathi Kanchi and Ms Eve Wang Chao, and PhD student, Ms Shreya Kar, from Dr Alan Prem Kumar’s group for winning awards at the International Conference on Scientific Frontiers in Natural Product Based Drugs (SFNPBD) 2017! This conference was co-organized by the Department of Pharmacology, Yong Loo

PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple Negative Breast Cancers. (Mol Cancer Ther, Aug 2017)

Luxi Chen1,2,3, Yi Yuan1, Shreya Kar1,2, Madhu M. Kanchi1, Suruchi Arora4, Ji E. Kim1, Pei F. Koh1,2, Einas Yousef5,6, Ramar P. Samy4, Muthu K. Shanmugam2, Tuan Z. Tan1, Sung W. Shin7, Frank Arfuso8, Han M. Shen4,9, Henry Yang1, Boon C. Goh1,2,10,11, Joo I. Park7, Louis Gaboury5, Peter E. Lobie1,2,11,12, Gautam Sethi2,13, Lina HK. Lim4,9,14,*, Alan

Tocotrienols: The unsaturated sidekick shifting new paradigms in vitamin E therapeutics. (Drug Discov Today, Aug 2017)

Kanchi MM1, Shanmugam MK2, Rane G3, Sethi G4, Kumar AP5. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore. 2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. 3 Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Department of Pharmacology,

CSI Staff Awarded at NUSMed Awards Ceremony 2017

Prof. Chng Wee Joo - Researcher of the Year, Dr. Polly Chen - Young Researcher of the Year, Dr. Alan Prem Kumar - Graduate Student Mentor of the Year Congratulations to Professor Chng Wee Joo, Dr. Polly Chen and Dr. Alan Prem Kumar, who were awarded for their research achievements at the NUS Medicine (NUSMed)

Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function. (Antioxid Redox Signal, July 2017)

Tan DQ1, Suda T2,3. Author information 1 National University of Singapore, Cancer Science Institute of Singapore, Singapore, Singapore; A0074009@u.nus.edu. 2 National University of Singapore, Cancer Science Institute of Singapore, Singapore, Singapore. 3 Kumamoto University, International Research Center for Medical Science, Kumamoto, Japan; sudato@z3.keio.jp. Abstract SIGNIFICANCE: The precise role and impact of reactive oxygen species (ROS)

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia. (J Hematol Oncol, July 2017)

Zhou J1,2, Bi C1, Ching YQ1, Chooi JY2, Lu X1, Quah JY1, Toh SH1, Chan ZL1, Tan TZ1, Chong PS1, Chng WJ3,4,5. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Republic of Singapore. 2 Department of Medicine, Yong Loo Lin School of

Release of HER2 repression of trefoil factor 3 (TFF3) expression mediates trastuzumab resistance in HER2+/ER+ mammary carcinoma. (Oncotarget, June 2017)

Chong QY1, You ML1,2, Pandey V1, Banerjee A1, Chen YJ1,2, Poh HM1,2, Zhang M1,2, Ma L3, Zhu T4,5, Basappa6, Liu L7,8, Lobie PE1,2,3,9. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3 Tsinghua Berkeley Shenzhen

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. (J Biol Chem, June 2017)

Xu L1, Liu X1, Sheng N2, Oo KS1, Liang J3, Chionh YH4, Xu J2, Ye F5, Gao YG5, Dedon PC6, Fu XY7. Author information 1 Cancer Science Institute of Singapore, Singapore. 2 Model Animal Research Center of Nanjing University, China. 3 National University of Singapore, Singapore. 4 Singapore-MIT Alliance for Research and Technology, Singapore. 5

Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression. (Int J Mol Sci, June 2017)

Chen YJ1, You ML2, Chong QY3, Pandey V4, Zhuang QS5, Liu DX6, Ma L7, Zhu T8,9, Lobie PE10,11. Author information 1 Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore 119077, Singapore. yjchen011@gmail.com. 2 Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore 119077, Singapore.

“Lnc”-ing Wnt in Female Reproductive Cancers: Therapeutic Potential of Long Non-Coding RNAs in Wnt Signaling. (Br J Pharmacol, July 2017)

Ong MS1, Cai W2,3, Yuan Y3, Leong HC2,3, Tan TZ3, Mohammad A3, You ML3, Arfuso F4, Goh BC2,3,5,6, Warrier S7,8, Sethi G2,8, Tolwinski NS9,10, Lobie PE2,11,12, Yap CT1,5, Hooi SC1, Huang RY11,3,5,13, Kumar AP2,3,5,7,14,15. Author information 1 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2 Department of Pharmacology,