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Prestigious STaR Award Renewed for Prof Toshio Suda

Find out more about Prof. Suda's first STaR award in 2014 here: https://www.csi.nus.edu.sg/ws/awards-achievements/prestigious-star-award-for-translational-research-awarded-to-two-csi-pis Find out more about the NMRC awards here: http://www.nmrc.gov.sg/grants/talent-development/stria

11th Hope Meeting with Nobel Laureates Inspires CSI PhD Student

Organized by the Japan Society for the Promotion of Science (JSPS), the 11th Hope Meeting with Nobel Laureates was held in Okinawa, Japan from 4-8 March 2019. Shreya Kar, Presidents’ Scholar PhD student from Dr. Alan Prem Kumar’s group, was privileged to be selected to attend this meeting. At the Hope Meetings each year, outstanding

Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice. (Leukemia, Mar 2019)

Han L1,2, Madan V3, Mayakonda A1, Dakle P1, Woon TW1, Shyamsunder P1, Nordin HBM1, Cao Z1, Sundaresan J1, Lei I4, Wang Z4, Koeffler HP1,5,6. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. csivm@nus.edu.sg. 4Department of

Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC “Niche Herein”. (Cell Stem Cell, Mar 2019)

Nakamura-Ishizu A1, Suda T2. Author Information 1Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. 2Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University,

PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. (Cell Rep, Feb 2019)

Tan DQ1, Li Y1, Yang C1, Li J1, Tan SH1, Chin DWL2, Nakamura-Ishizu A1, Yang H1, Suda T3. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Department of Medicine, Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden. 3Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Electronic address: csits@nus.edu.sg. Abstract Protein arginine methyltransferase

CSI Research Fellow Nominated to Attend Global Young Scientists’ Summit

Congratulations to Dr Xianning Lai, a research fellow in Dr Alan Prem Kumar’s group for being successfully nominated to attend the Global Young Scientists’ Summit (GYSS) @one-north from 20 to 25 January. She was one of the highly motivated and passionate PhD students and postdoctoral associates under 35 chosen from all over the world to participate

2018 Year in Review: Research Highlights

From identifying candidate targets for treatments of Glioblastoma (GBM) to developing a computational platform to facilitate drug combination design, 2018 has been an exciting year for the cancer research field. Here is a look back on some of our research highlights in 2018: 1. ARID5B as a critical downstream target of the TAL1 complex that

[Review] Understanding the cancer stem cell phenotype: A step forward in the therapeutic management of cancer. (Biochem Pharmacol, Jan 2019)

Wong ALA1, Bellot GL2, Hirpara JL3, Pervaiz S4 Author information 1Cancer Science Institute, National University of Singapore, Singapore; Department of Hematology-Oncology, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2Department of Hand & Reconstructive Microsurgery, University Orthopedic, Hand & Reconstructive Microsurgery Cluster, National University Health System, Singapore;

[Review] ROS and the DNA damage response in cancer. (Redox Biol, Dec 2018)

Srinivas US1, Tan BWQ1, Vellayappan BA2, Jeyasekharan AD3. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Radiation Oncology, National University Hospital, Singapore. 3Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Hospital, Singapore. Electronic address: csiadj@nus.edu.sg. Abstract Reactive oxygen species (ROS) are a group of short-lived,

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance. (Redox Biol, Dec 2018)

Hirpara J1, Eu JQ1, Tan JKM2, Wong AL3, Clement MV4, Kong LR1, Ohi N5, Tsunoda T6, Qu J7, Goh BC8, Pervaiz S9. Author information 1Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore. 2Genome Institute of Singapore, Singapore 138672, Singapore; Department of Physiology and Medical Science Cluster Cancer ProgramYong Loo Lin School of Medicine, National University of Singapore, Singapore 119753, Singapore. 3Cancer Science Institute, National University of Singapore,