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[Review] ROS and the DNA damage response in cancer. (Redox Biol, Dec 2018)

Srinivas US1, Tan BWQ1, Vellayappan BA2, Jeyasekharan AD3. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Radiation Oncology, National University Hospital, Singapore. 3Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Hospital, Singapore. Electronic address: csiadj@nus.edu.sg. Abstract Reactive oxygen species (ROS) are a group of short-lived,

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance. (Redox Biol, Dec 2018)

Hirpara J1, Eu JQ1, Tan JKM2, Wong AL3, Clement MV4, Kong LR1, Ohi N5, Tsunoda T6, Qu J7, Goh BC8, Pervaiz S9. Author information 1Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore. 2Genome Institute of Singapore, Singapore 138672, Singapore; Department of Physiology and Medical Science Cluster Cancer ProgramYong Loo Lin School of Medicine, National University of Singapore, Singapore 119753, Singapore. 3Cancer Science Institute, National University of Singapore,

[Review] Chromatin Interactions and Regulatory Elements in Cancer: From Bench to Bedside. (Trends Genet, Dec 2018)

See YX1, Wang BZ1, Fullwood MJ2. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore; These authors made equal and critical contributions. 2Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.

Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. (Haematologica, Dec 2018)

Lao ZT1, Ding LW2, An O3, Hattori N4, Sun QY3, Tan KT5, Mayakonda A3, Chuan WG6, Madan V3, Lin DC7, Yang H3, Koeffler HP3. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Cancer Science Institute of Singapore; csidlw@nus.edu.sg. 3Cancer Science Institute of Singapore. 4Division of Hematology, Department of Medicine, Showa University, Tokyo, Japan. 5Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts.

MMSET I acts as an oncoprotein and regulates GLO1 expression in t(4;14) multiple myeloma cells. (Leukemia, Nov 18)

Xie Z1, Chooi JY2, Toh SHM1, Yang D3, Basri NB3, Ho YS3, Chng WJ4,5,6. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. 3Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore. 4Cancer Science Institute of

Frontiers in Cancer Science 2018

   The annual Frontiers in Cancer Science (FCS) conference marked its 10th Anniversary this year with the successful conclusion of its 10th meeting this year, held from 12-14 November at the University Cultural Centre, NUS. Proudly and jointly organized by the Cancer Science Institute of Singapore (CSI Singapore), Duke-NUS Medical School (Duke-NUS), Genome Institute of

MethMotif: an integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles. (Nucleic Acids Res, Oct 2018)

Xuan Lin QX1, Sian S1, An O1, Thieffry D2, Jha S1,3, Benoukraf T1,4. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Computational Systems Biology Team, Institut de Biologie de l'École Normale Supérieure (IBENS), INSERM, École Normale Supérieure, PSL Research University, Paris, France. 3Department of Biochemistry, National University of Singapore, Singapore, Singapore. 4Discipline of Genetics, Faculty of

Maftools: efficient and comprehensive analysis of somatic variants in cancer. (Genome Res, Nov 2018)

Mayakonda A1,2, Lin DC3, Assenov Y2,4, Plass C2,4, Koeffler HP1,3,5. Author information 1Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore. 2Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. 3Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. 4German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany. 5National University Cancer Institute, National University Hospital,

[Review] Role of tumor-derived exosomes in cancer metastasis. (Biochim Biophys Acta Rev Cancer, Nov 2018)

Wee I1, Syn N1, Sethi G2, Goh BC3, Wang L4. Author information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. 2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address: phcgs@nus.edu.sg. 3Cancer Science Institute of Singapore, National

Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. (Cell Rep, Nov 2018)

Nakamura-Ishizu A1, Matsumura T2, Stumpf PS3, Umemoto T4, Takizawa H4, Takihara Y2, O'Neil A2, Majeed ABBA2, MacArthur BD5, Suda T6. Author information 1Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599 Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address: ayaknakm@gmail.com. 2Cancer Science Institute, National University of Singapore, 14 Medical Drive,