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Targetable BET Proteins- and E2F1-dependent Transcriptional Program Maintains the Malignancy of Glioblastoma. (Proc Natl Acad Sci USA, May 2018)

Xu L1, Chen Y2, Mayakonda A2, Koh L3,4, Chong YK3, Buckley DL5, Sandanaraj E3,4,6, Lim SW3, Lin RY2, Ke XY2, Huang ML2,7, Chen J8, Sun W4, Wang LZ2,9, Goh BC2,9,10, Dinh HQ11, Kappei D2, Winter GE5, Ding LW2, Ang BT6,12,13,14, Berman BP11, Bradner JE5,15, Tang C3,8,13, Koeffler HP2,10,16. Author Information 1Cancer Science Institute of Singapore,

The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway. (Stem Cell Reports, Apr 2018)

Gu H1, Do DV2, Liu X3, Xu L3, Su Y4, Nah JM5, Wong Y3, Li Y3, Sheng N6, Tilaye GA4, Yang H3, Guo H5, Yan J6, Fu XY7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, 117599; Centre for Life Sciences, National University of Singapore, Singapore, Singapore, 117456. 2Department of

Identification of Novel lncRNAs Regulated by the TAL1 Complex in T-cell ALL. (Leukemia, Mar 2018)

Thi Ngoc PC1, Tan SH1, Tan TK1, Chan MM1, Li Z2, Yeoh AEJ2,3, Tenen DG1,4,5, Sanda T6,7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. 3VIVA-University

CSI Student Receives Gold Award at the Singapore Science and Engineering Fair (SSEF) 2018 Ceremony

Our warmest congratulations to Benjamin Paik, attachment student from Dr Alan Prem Kumar’s group who clinched the Gold Award at the Singapore Science and Engineering Fair (SSEF) 2018, held from 7-8 March 2018. He received the award at the joint A*STAR Talent Search and Singapore Science and Engineering Fair Award Ceremony held on 26 April at

CSI Welcomes President of University of Zurich

CSI Singapore was honoured to host a visit from Prof Michael Hengartner, President of the University of Zurich, on 7 May 2018.  It was an interactive session hosted by our Deputy Director, Prof Chng Wee Joo, who provided an overview of the research work at CSI, followed by a lab tour of our world class

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer. (Oncotarget, Mar 2018)

Madhura Kulkarni,1,4 Tuan Zea Tan,1 Nurfarhanah Bte Syed Sulaiman,1 John M. Lamar,2,5 Prashali Bansal,1,6 Jianzhou Cui,1 Yiting Qiao,1 and Yoshiaki Ito1,3. Author Information 1Cancer Science Institute, NUS, Singapore. 2Transnational Cancer Research Centre, Prashanti Cancer Care Mission and Indian Institute of Science Education and Research, Pune, India. 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. (Leukemia, Mar 2018)

Thi Ngoc PC1, Tan SH1, Tan TK1, Chan MM1, Li Z2, Yeoh AEJ2,3, Tenen DG1,4,5, Sanda T6,7. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 2 Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore 3 VIVA-University Children's Cancer Centre, Khoo Teck

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. (Nat Commun, Apr 2018)

Akihiko Numata1, Hui Si Kwok1, Akira Kawasaki1, Jia Li1, Qi-Ling Zhou1, Jon Kerry2, Touati Benoukraf1,Deepak Bararia1, Feng Li1, Erica Ballabio2, Marta Tapia2, Aniruddha J. Deshpande3, Robert S. Welner4,Ruud Delwel5, Henry Yang1, Thomas A. Milne2, Reshma Taneja6; Daniel G. Tenen1,7 Author Information: 1 Cancer Science Institute of Singapore, National University of Singapore 2 MRC Molecular Haematology

CSI Singapore Conferred Two Awards at the Global Breast Cancer Conference 2018

Congratulations to Dr Alan Prem Kumar, CSI Principal Associate who clinched the Outstanding Oral Presentation Award at the recent Global Breast Cancer Conference (GBCC), hosted by the Korean Breast Cancer Society and supported by the Korean Breast Cancer Foundation, which was held on 5-7 April 2018 at Incheon, South Korea. Marked as one of the

Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement. (Br J Haematol, Mar 2018)

Ding LW1, Tan KT1, Sun QY1, Lao ZT1,2, Yang H1, Jiang N3, Chien W4, Xiao JF1, Loh XY1, Huang ML1, Lill M4, Lin DC4, Yeoh AEJ1,3, Koeffler HP1,4. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Haematology, Singapore General Hospital, Singapore. 3Department of Paediatrics, Yong Loo Lin School of