Viewing Research

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion. (Haematologica, Aug 2018)

Madan V1, Han L2, Hattori N3, Teoh WW2, Mayakonda A2, Sun QY2, Ding LW2, Binte Mohd Nordin H2, Lim SL2, Shyamsunder P2, Dakle P2, Sundaresan J2, Doan NB4, Sanada M5, Sato-Otsubo A6, Meggendorfer M7, Yang H2, Said JW4, Ogawa S6, Haferlach T7, Liang DC8, Shih LY9, Nakamaki T3, Wang QT10, Koeffler HP11. Author information 1

Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP). (Sci Trans Med, Aug 2018)

Rashid MBMA1,2, Toh TB1, Hooi L1, Silva A3, Zhang Y1, Tan PF4, Teh AL4, Karnani N4,5, Jha S1,5, Ho CM3,6,7, Chng WJ1,8, Ho D2,6,7,9,10,11, Chow EK12,2. Author information 1 Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore. 2 Department of Pharmacology, Yong Loo Lin School

TIP60 represses activation of endogenous retroviral elements. (Nucleic Acids Res, Aug 2018)

Rajagopalan D1,2, Tirado-Magallanes R1, Bhatia SS1, Teo WS1, Sian S1, Hora S1,2, Lee KK1, Zhang Y1, Jadhav SP1, Wu Y3, Gan YH2, Karnani N2,3, Benoukraf T1, Jha S1,2. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599. 2 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of

Aberrant hyperediting of myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis. (Blood, Aug 2018)

Teoh PJ1, An O1, Chung TH1, Chooi JY1, Toh SHM1, Fan S2, Wang W3, Koh BTH4, Fullwood MJ5, Ooi MG6, de Mel S7, Soekojo CY6, Chen L8, Ng SB9, Yang H1, Chng WJ10. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Department of Pathology, National University Hospital, National University

Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial. (BMC Med, Jul 2018)

Syn NL1,2, Wong AL1,2, Lee SC1,2, Teoh HL3, Yip JWL4, Seet RC3,5, Yeo WT4, Kristanto W4, Bee PC6, Poon LM1, Marban P1, Wu TS7, Winther MD8, Brunham LR9,10, Soong R2,11, Tai BC12, Goh BC13,14,15. Author information 1 Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore. 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore,

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. (PNAS, Jul 2018)

Liu BH1, Jobichen C1,2, Chia CSB3, Chan THM1, Tang JP1, Chung TXY1, Li J1, Poulsen A3,4, Hung AW3, Koh-Stenta X3, Tan YS5, Verma CS2,5,6, Tan HK1,7, Wu CS1, Li F1, Hill J3, Joy J3, Yang H1, Chai L8, Sivaraman J9, Tenen DG10,11. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, 117599

Biomarkers for Homologous Recombination Deficiency in Cancer. (J Natl Cancer Inst, May 2018)

Hoppe MM1, Sundar R2, Tan DSP1,2, Jeyasekharan AD1,2. Author Information 1 Cancer Science Institute of Singapore, National University Hospital, Singapore. 2 Department of Haematology-Oncology, National University Hospital, Singapore. Abstract Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA repair pathway of clinical interest due to the sensitivity of homologous recombination-deficient

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis. (Int J Mol Sci, Jun 2018)

Yeo-Teh NSL1,2, Ito Y3,4, Jha S5,6. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2 NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore. 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 4 NUS Graduate School for

CARD10, a CEBPE target involved in granulocytic differentiation. (Haematologica, May 2018)

Shyamsunder P1, Sankar H2, Mayakonda A2, Han L3, Nordin HBM2, Woon TW2, Shanmugasundaram M2, Dakle P2, Madan V2, Koeffler HP4. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 3 Cancer Science Institute, Department of Medicine, Yong Loo Lin School

The MYC/BMI1 axis is essential for SETDB1-mediated breast tumorigenesis. (J Pathol, Jun 2018)

Xiao JF1, Sun QY1, Ding LW1, Chien W2, Liu XY1, Mayakanda A1, Jiang YY1, Loh XY1, Ran XB1, Doan NB3, Castor B3, Chia D4, Said JW3, Tan KT1, Yang H1, Fu XY1,5, Lin DC2, Koeffler HP1,2. Author information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2 Division of Hematology/Oncology, Cedar-Sinai Medical