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Targetable BET Proteins- and E2F1-dependent Transcriptional Program Maintains the Malignancy of Glioblastoma. (Proc Natl Acad Sci USA, May 2018)

Xu L1, Chen Y2, Mayakonda A2, Koh L3,4, Chong YK3, Buckley DL5, Sandanaraj E3,4,6, Lim SW3, Lin RY2, Ke XY2, Huang ML2,7, Chen J8, Sun W4, Wang LZ2,9, Goh BC2,9,10, Dinh HQ11, Kappei D2, Winter GE5, Ding LW2, Ang BT6,12,13,14, Berman BP11, Bradner JE5,15, Tang C3,8,13, Koeffler HP2,10,16. Author Information 1Cancer Science Institute of Singapore,

The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway. (Stem Cell Reports, Apr 2018)

Gu H1, Do DV2, Liu X3, Xu L3, Su Y4, Nah JM5, Wong Y3, Li Y3, Sheng N6, Tilaye GA4, Yang H3, Guo H5, Yan J6, Fu XY7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, 117599; Centre for Life Sciences, National University of Singapore, Singapore, Singapore, 117456. 2Department of

Identification of Novel lncRNAs Regulated by the TAL1 Complex in T-cell ALL. (Leukemia, Mar 2018)

Thi Ngoc PC1, Tan SH1, Tan TK1, Chan MM1, Li Z2, Yeoh AEJ2,3, Tenen DG1,4,5, Sanda T6,7. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. 3VIVA-University

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer. (Oncotarget, Mar 2018)

Madhura Kulkarni,1,4 Tuan Zea Tan,1 Nurfarhanah Bte Syed Sulaiman,1 John M. Lamar,2,5 Prashali Bansal,1,6 Jianzhou Cui,1 Yiting Qiao,1 and Yoshiaki Ito1,3. Author Information 1Cancer Science Institute, NUS, Singapore. 2Transnational Cancer Research Centre, Prashanti Cancer Care Mission and Indian Institute of Science Education and Research, Pune, India. 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. (Leukemia, Mar 2018)

Thi Ngoc PC1, Tan SH1, Tan TK1, Chan MM1, Li Z2, Yeoh AEJ2,3, Tenen DG1,4,5, Sanda T6,7. Author Information 1 Cancer Science Institute of Singapore, National University of Singapore, Singapore 2 Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore 3 VIVA-University Children's Cancer Centre, Khoo Teck

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. (Nat Commun, Apr 2018)

Akihiko Numata1, Hui Si Kwok1, Akira Kawasaki1, Jia Li1, Qi-Ling Zhou1, Jon Kerry2, Touati Benoukraf1,Deepak Bararia1, Feng Li1, Erica Ballabio2, Marta Tapia2, Aniruddha J. Deshpande3, Robert S. Welner4,Ruud Delwel5, Henry Yang1, Thomas A. Milne2, Reshma Taneja6; Daniel G. Tenen1,7 Author Information: 1 Cancer Science Institute of Singapore, National University of Singapore 2 MRC Molecular Haematology

Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement. (Br J Haematol, Mar 2018)

Ding LW1, Tan KT1, Sun QY1, Lao ZT1,2, Yang H1, Jiang N3, Chien W4, Xiao JF1, Loh XY1, Huang ML1, Lill M4, Lin DC4, Yeoh AEJ1,3, Koeffler HP1,4. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2Department of Haematology, Singapore General Hospital, Singapore. 3Department of Paediatrics, Yong Loo Lin School of

A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers. (Int J Cancer, Mar 2018)

Kwok ZH1, Roche V1, Chew XH1, Fadieieva A1, Tay Y1,2. Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Abstract Long noncoding RNAs (lncRNAs) constitute one of the largest classes of transcripts and have

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase. (J Hematol Oncol, Mar 2018)

Zhou J1,2, Toh SH1, Chan ZL1, Quah JY1, Chooi JY2, Tan TZ1,3, Chong PSY1, Zeng Q4, Chng WJ5,6,7. 1 Cancer Science Institute of Singapore, Singapore, Singapore. 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 3 Translational Centre for Development and Research, National University Health System, Singapore, Singapore.

Increased Expression of the Long Non-coding RNA LINC01503, Regulated by TP63, in Squamous Cell Carcinoma and Effects on Oncogenic Activities of Cancer Cell Lines. (Gastroenterology, Feb 2018)

Xie JJ1, Jiang YY2, Jiang Y2, Li CQ3, Chee LM2, An O2, Mayakonda A2, Ding LW2, Long L4, Sun C4, Lin LH5, Chen L5, Wu JY4, Wu ZY6, Cao Q5, Fang WK4, Yang W7, Meltzer SJ8, Yang H2, Fullwood M9, Xu LY10, Li EM11, Lin DC12, Koeffler HP13. 1 Department of Biochemistry and Molecular Biology,