Cancer Systems Biology Mini Symposium

CSI organized the Cancer Systems Biology Mini-Symposium, a themed series of talks relevant to Bioinformatics, on the 26 November 2015.

Professor Lodewyk Wessels, Group Leader of the Computation Cancer Biology Group in the Netherlands Cancer Institute, Dr Laurence Calzone and Dr Andrei Zinovyev, both Research Engineers from Institut Curie shared about their work in this symposium.

Prof. Wessels’ laboratory focuses on the development of efficient computational approaches to process a variety of research data with the goal of generating testable hypotheses in order to validate their approaches and advance their capacity to comprehend and treat cancer patients. He gave an impressing talk on “Modelling Pharmacogenomic Interactions in Cancer” detailing how his group used logic-based modeling to uncover combinations of aberrations that specifically sensitize to drugs and ultimately projecting the identified markers back into primary tumors to capture their clinical relevance.

Dr Calzone and Dr Zinoyvey from France delivered a talk on “Identifying the Interaction Between p53 and Notch Pathway in Triggering Metastasis: From Maps to Models”. It was a fascinating talk which explained how they gathered the information from Atlas of Cancer Signalling Network (ACSN), a global map of molecular mechanisms implicated in cancer, to build a logical model focusing on metastasis. Both Research Engineers belong to the Computational Systems Biology of Cancer research group in Institut Curie. The group aims to contribute to the development of new strategies for human cancer treatment, propose new target molecules and cancer drugs. They seek to achieve their aim by integrating available or deducible information on molecular structures and interaction with other sources of data to create a mechanistical or statistical models of human cancer in order to predict tumor evolution.

This symposium was a success and was well received by scientists and students who were interested in Cancer Systems Biology.