Babu D1, Fullwood MJ1,2.
1 Cancer Science Institute of Singapore, National University of Singapore, Singapore.
2 School of Biological Sciences, Nanyang Technological University, Singapore, and the Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.