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“Lnc”-ing Wnt in Female Reproductive Cancers: Therapeutic Potential of Long Non-Coding RNAs in Wnt Signaling. (Br J Pharmacol, July 2017)

Ong MS1, Cai W2,3, Yuan Y3, Leong HC2,3, Tan TZ3, Mohammad A3, You ML3, Arfuso F4, Goh BC2,3,5,6, Warrier S7,8, Sethi G2,8, Tolwinski NS9,10, Lobie PE2,11,12, Yap CT1,5, Hooi SC1, Huang RY11,3,5,13, Kumar AP2,3,5,7,14,15.

Author information
1 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3 Cancer Science Institute of Singapore, National University of Singapore, Singapore.
4 Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
5 National University Cancer Institute, National University Health System, Singapore.
6 Department of Haematology-Oncology, National University Health System, Singapore.
7 Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, India.
8 School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
9 Division of Science, Yale-NUS College, Singapore.
10 Department of Biological Science, National University of Singapore, Singapore.
11 Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
12 Tsinghua Berkeley Shenzhen Institute and Division of Life Science and Health, Tsinghua University Graduate School, Shenzhen, P. R. China.
13 Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
14 Curtin Medical School, Faculty of Health Science, Curtin University, Perth, WA, Australia.
15 Department of Biological Sciences, University of North Texas, Denton, Texas, USA.

Abstract
Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology; non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are amongst some that have gained attention recently in human diseases, including cancer, with the involvement of many more ncRNAs waiting to be discovered. Non-coding RNAs (ncRNAs) are a group of ribonucleic acids transcribed from regions of the human genome, which do not become translated into proteins, despite having essential roles in cellular physiology. Deregulation of ncRNA expression and function has been observed in cancer pathogenesis. Recently, the roles of a group of ncRNA known as lncRNA have gained attention in cancer, with increasing reported literature on their oncogenic involvement. Female reproductive cancers remain a leading cause of death in the female population, accounting for almost a third of all female cancer deaths in 2016. The Wnt signaling pathway is one of the most important oncogenic signaling pathways found hyperactivated in cancers, including female reproductive cancers. The advent of ncRNA research into their mechanistic roles in human cancers has also led to novel reported roles of ncRNAs in the Wnt pathway and Wnt-mediated oncogenesis. This review aims to provide a critical summary of the respective roles and cellular functions of Wnt-associated lncRNAs in female reproductive cancers and explores the potential of circulating cell-free lncRNAs as diagnostic markers and lncRNAs as therapeutic targets.

PMID: 28736855