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Tocotrienols: The unsaturated sidekick shifting new paradigms in vitamin E therapeutics. (Drug Discov Today, Aug 2017)

Kanchi MM1, Shanmugam MK2, Rane G3, Sethi G4, Kumar AP5.

Author information
1 Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.
2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
3 Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
4 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia. Electronic address: phcgs@nus.edu.sg.
5 Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; National University Cancer Institute, National University Health System, 119074, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia; Department of Biological Sciences, University of North Texas, Denton, TX 76203-5017, USA. Electronic address: csiapk@nus.edu.sg.

Abstract
Vitamin E family members: tocotrienols and tocopherols are widely known for their health benefits. Decades of research on tocotrienols have shown they have diverse biological activities such as antioxidant, anti-inflammatory, anticancer, neuroprotective and skin protection benefits, as well as improved cognition, bone health, longevity and reduction of cholesterol levels in plasma. Tocotrienols also modulate several intracellular molecular targets and, most importantly, have been shown to improve lipid profiles, reduce total cholesterol and reduce the volume of white matter lesions in human clinical trials. This review provides a comprehensive update on the little-known therapeutic potentials of tocotrienols, which tocopherols lack in a variety of inflammation-driven diseases.

PMID: 28789906