CHAN Shing Leng
The Xenograft Assay Facility is a research core that maintains strains of immunocompromised mice for xenograft experiments. We maintain strains such as non-obese diabetic (NOD)/severe combined immune deficiency (SCID) and NOD/SCID/interleukin 2 (IL2) receptor null (NOG) mice. The current established models include xenografting of normal haematopoietic stem cells and primary gastric cancer cells. Currently we have 8 lines of patient-derived xenograft from gastric cancer samples of various histological subtypes. Specific signaling pathway analyses by real-time PCR indicate that these xenografts are distinct from each other and may represent different molecular subtypes. Molecular profiling of these xenografts is underway.