Xenograft Cancer Models Facility

Facility Head:

Dr CHAN Shing Leng,

CSI Singapore
Email: csicsl[at]nus.edu.sg

Recent development of transplantable patient-derived cancer tissue xenograft (PDX) lines generated by grafting of fresh cancer tissues in immunodeficient mice (e.g., NOD/SCID, NOG mice) offers more realistic preclinical cancer models in terms of their histopathological and genetic profiles. The Cancer Models Facility has established a repository of PDX models for gastric cancer (Table1). These PDX models closely resemble human cancer rather than cell lines and are well annotated, which allowed many basic oncology research questions to be addressed. We work closely with clinicians in the University Surgery Cluster and we will expand our collection of PDX models to include lung cancer that has an Asian phenotype in the coming year.

ID Histology
Intestinal Subtype
GC21 Moderately differentiated
GC45 Moderately differentiated
GC66 Poorly differentiated
GC84 Poorly differentiated
GC113 Moderately differentiated
GC117 Poorly differentiated (5-49% gland formation)
GC119 Moderately differentiated
GC121 Poorly differentiated
GC126 To be determined
GC127 Moderately differentiated
GC135 Moderately to poorly differentiated
GC138 Undifferentiated carcinoma
GC141 Moderately differentiated
Diffuse Subtype
GAGA1 Signet ring cell
GAGA3 Signet ring cell
GAGA6 Signet ring cell
GAGA8 To be determined
GAGA9 Poorly cohesive carcinoma
JAJA2 Signet ring cell
GC133 Signet ring cell

Table 1: List of patient-derived xenograft lines.