Publication Highlights

Selected publications: Jun 2016 – Apr 2017

  1. BCL6 promotes glioma and serves as a therapeutic target. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. Proc Natl Acad Sci U S A. 2017 Apr 11; 114(15):3981-3986.
  1. Belinostat exerts anti-tumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma. Kong LR, Tan TZ, Ong WR, Bi C, Huynh H, Lee SC, Chng WJ, Eichhorn PJ, Goh BC. Mol Oncol. 2017 Apr 11
  1. USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7. Kit Leng Lui S, Iyengar PV, Jaynes P, Isa ZF, Pang B, Tan TZ, Eichhorn PJ. EMBO Rep. 2017 Apr 5
  1. Nanodiamond-Manganese dual mode MRI contrast agents for enhanced liver tumor detection. Hou W, Toh TB, Abdullah LN, Yvonne TWZ, Lee KJ, Guenther I, Chow EK. Nanomedicine. 2017 Apr; 13(3):783-793.
  1. Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, Alpermann T, Haferlach T, Yang H, Koeffler HP. Leukemia. 2017 Mar; 31(3):762-766
  1. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VK, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP. Clin Cancer Res. 2017 Mar 23
  1. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman B, Song E, Yin D, Koeffler HP. Cancer Res. 2017 Feb 20
  1. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Liau WS, Tan SH, Ngoc PC, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T. Leukemia. 2017 Jan 27.
  1. Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y. Gastroenterology. 2017 Jan; 152(1):218-231.e14.
  1. Mutational landscape of pediatric acute lymphoblastic leukemia. Ding LW, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh Yeoh A, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernández LT, Preethi H, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP. Cancer Res. 2017 Jan 15; 77(2):390-400. Correction
  1. Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP. Leukemia. 2017 Jan; 31(1):1-10.
  1. ADAR-mediated RNA editing predicts progression and prognosis of Gastric Cancer. Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L. Gastroenterology. 2016 Oct; 151(4):637-650.e10.
  1. The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer. Antony J, Tan TZ, Kelly Z, Low J, Choolani M, Recchi C, Gabra H, Thiery JP, Huang RY. Sci Signal. 2016 Oct 4; 9(448):ra97.
  1. TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program. Zhang Y, Subbaiah VK, Rajagopalan D, Tham CY, Abdullah LN, Toh TB, Gong M, Tan TZ, Jadhav SP, Pandey AK, Karnani N, Chow EK, Thiery JP, Jha S. J Mol Cell Biol. 2016 Sep 20.
  1. Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma. Loo SY, Hirpara JL, Pandey V, Tan TZ, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S, Clément MV, Kumar AP. Antioxid Redox Signal. 2016 Aug 20; 25(6):283-99
  1. EZH2 phosphorylation by JAK3 mediates a switch to non-canonical function in natural killer/T-cell lymphoma. Yan J, Li B, Lin B, Lee PT, Chung TH, Tan J, Bi C, Lee XT, Selvarajan V, Ng SB, Yang H, Yu Q, Chng WJ. Blood. 2016 Aug 18; 128(7):948-58.
  1. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O’Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E. Sci Transl Med. 2016 Aug 3; 8(350):350ra104.
  1. CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer. Roy RK, Hoppe MM, Srivastava S, Samanta A, Sharma N, Tan KT, Yang H, Voon DC, Pang B, Teh M, Murata-Kamiya N, Hatakeyama M, Chang YT, Yong WP, Ito Y, Ho KY, Tan P, Soong R, Koeffler PH, Yeoh KG, Jeyasekharan AD. Oncotarget. 2016 Aug 23; 7(34):55290-55301.
  1. HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q. Proc Natl Acad Sci U S A. 2016 Jun 28; 113(26):E3735-44.
  1. Pharmacogenetics-Guided Phase I Study of Capecitabine on an Intermittent Schedule in Patients with Advanced or Metastatic Solid Tumours. Soo RA, Syn N, Lee SC, Wang L, Lim XY, Loh M, Tan SH, Zee YK, Wong AL, Chuah B, Chan D, Lim SE, Goh BC, Soong R, Yong WP. Sci Rep. 2016 Jun 14; 6:27826.