Publication Highlights

Selected publications: January – December 2017

  1. A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer. Chan JJ, Kwok ZH, Chew XH, Zhang B, Liu C, Soong TW, Yang H, Tay Y. Nucleic Acids Res. 2017 Dec 12. doi: 10.1093/nar/gkx1248.
  2. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage S, Tyner JW, Lin DC, Koeffler HP. Cancer Res. 2017 Dec 1;77(23):6614-6626. doi: 10.1158/0008-5472.CAN-17-1143.
  3. Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia. Wong RWJ, Ngoc PCT, Leong WZ, Yam AWY, Zhang T,3, Asamitsu K, Iida S, Okamoto T, Ueda R, Gray NS, Ishida T, Sanda T. Blood. 2017 Nov 23;130(21):2326-2338. doi: 10.1182/blood-2017-06-792184.
  4. EBV-associated primary nodal T/NK-cell lymphoma shows distinct molecular signature and copy number changes. Ng SB, Chung TH, Kato S, Nakamura S, Takahashi E, Ko YH, Khoury JD, Yin CC, Soong R, Jeyasekharan AD, Hoppe MM, Selvarajan V, Tan SY, Lim ST, Ong CK, Nairismägi ML, Maheshwari P, Choo SN, Fan S, Lee CK, Chuang SS, Chng WJ. Haematologica. 2017 Nov 2. pii: haematol.2017.180430. doi: 10.3324/haematol.2017.180430.
  5. PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers. Chen L, Yuan Y, Kar S, Kanchi MM, Arora S, Kim JE, Koh PF, Yousef E, Samy RP, Shanmugam MK, Tan TZ, Shin SW, Arfuso F, Shen HM, Yang H, Goh BC, Park JI, Gaboury L, Lobie PE, Sethi G, Lim LHK, Kumar AP. Mol Cancer Ther. 2017 Nov;16(11):2528-2542. doi: 10.1158/1535-7163.MCT-16-0739.
  6. TGFβ Promotes Genomic Instability after Loss of RUNX3. Krishnan V, Chong YL, Tan TZ, Kulkarni M, Bin Rahmat MB, Tay LS, Sankar H, Jokhun DS, Ganesan A, Chuang LSH, Voon DC, Shivashankar GV, Thiery JP, Ito Y. Cancer Res. 2018 Jan 1;78(1):88-102. doi: 10.1158/0008-5472.CAN-17-1178. Epub 2017 Oct 26.
  7. TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S. PLoS Pathog. 2017 Oct 18;13(10):e1006681. doi: 10.1371/journal.ppat.1006681.
  8. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer. Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L. Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451.
  9. dbCoRC: a database of core transcriptional regulatory circuitries modeled by H3K27ac ChIP-seq signals. Huang M, Chen Y, Yang M, Guo A, Xu Y, Xu L, Koeffler HP. Nucleic Acids Res. 2017 Sep 5.
  10. Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma. Kong LR, Tan TZ, Ong WR, Bi C, Huynh H, Lee SC, Chng WJ, Eichhorn PJA, Goh BC. Mol Oncol. 2017 Aug;11(8):965-980. doi: 10.1002/1878-0261.12064.
  11. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VKM, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP. Clin Cancer Res. 2017 Aug 1;23(15):4376-4387. doi: 10.1158/1078-0432.CCR-16-2185.
  12. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T. Leukemia. 2017 Aug;31(8):1798-1807. doi: 10.1038/leu.2016.392.
  13. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman BP, Song EW, Yin D, Koeffler HP. Cancer Res. 2017 May 1;77(9):2255-2265. doi: 10.1158/0008-5472.CAN-16-2822.
  14. BCL6 promotes glioma and serves as a therapeutic target. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Corrections
  15. Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, Alpermann T, Haferlach T, Yang H, Koeffler HP. Leukemia. 2017 Mar;31(3):762-766. doi: 10.1038/leu.2016.343.