Jean-Paul THIERY

Prof Jean-Paul Thiery’s focus of research is to unravel the mechanisms of invasion and metastasis of carcinoma cells. His seminal contributions in the study of bladder carcinoma have led to the discovery of molecular mechanisms governing the formation of superficial or invasive tumors. His current studies involve oncogenomics and functional approaches to characterise breast carcinoma basal subtypes and ovarian carcinoma. Prof Thiery is also known for his studies on mechanochemistry of cell adhesion and migration and for his work on the ontogeny of neural crest.

The Ovarian Cancer Research Programme is aimed to utilize systems approaches in both in vitro and in vivo preclinical models to achieve translational needs for novel diagnostic and therapeutic strategies. This Programme is jointly led by Jean Paul Thiery and Ruby Yun-Ju Huang. The current area of investigation in our laboratory is to understand the contribution of epithelial plasticity in cancer “stemness”, tumour progression and therapeutic responses and to decipher the regulatory mechanisms behind it. The ultimate goal is to achieve personalized medicine in the diagnosis and treatment for ovarian cancer patients.

Selected Publications:

  1. Tan T.Z., Huang R.Y.H , Miow Q.H., Wong M.K.,Ye J., Lau J.A., Wu M.C., Bin Abdul Hadi L.H., Soong R., Choolani M , Ben Davidson B., Nesland J., Matsumura N., Mandai M., Konishi I., Chang J.T.,  Thiery J.P*., S. Mori  (2012) A Molecular Classification Scheme of Ovarian Serous Adenocarcinoma To Explore Novel Therapeutic Strategies. EMBO Mol Med in press *CoPI
  2. Bidard, FC, Pierga, JY, Soria, JC and Thiery, JP (2013) A clinical perspective on the metastatic process. Nat Rev Clin Onc. Epub
  3. Laiyi L, Chu YS Thiery JP Lim CT and I Rodriguez (2013) Microfluidic cell trap array for controlled positioning of single cells on adhesive micropatterns. Lab On Chip Epub.
  4. Chua KN, Sim WJ, Racine V, Shi Yl, Goh BC and JP Thiery (2012) A Cell-Based Small Molecule Screening Method for Identifying Inhibitors of Epithelial-Mesenchymal Transition in Carcinoma..PLoS One Epub
  5. Voon DC, Wang H, Koo JKW, NguyenTAP, Hor YT, Chu YS, Ito K, Fukamachi H, Shing Chan SK, Thiery JP* and Y Ito. (2012) Runx3 protects gastric epthelium against epithelial-mesenchymal transition induced cellular plasticity and tumorigenicity. Stem Cells Epub *CopI
  6. Toh B., X. Wang, J. Keeble, W. J. Sim ,K. Khoo,M. Kato, A. Prevost-Blondel  J.P. Thiery* and  J.P. Abastado.(2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PloS Biology Epub *CoPI
  7. Martinez-Rico C, Pincet F., Thiery JP*. and Dufour S.(2010). Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src kinase activation and actomyosin contractility. J.Cell. Science 123: 712-722.*CoPI
  8. Thiery JP, Acloque H, Huang YJH and Nieto A. (2009)  Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
  9. Taddei I, Deugnier MA, Faraldo MM, Petit V, Bouvard D, Medina D, Fässler R,Thiery JP* and Glukhova MA.(2008) beta1integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol 10: 716-722.*CoPI
  10. Bollet MA, Servant N., Neuvial P., Decraene C., Lebigot I., Meyniel JP., De Rycke Y., Savignoni A., Rigaill G., Fourquet A., Sigal-Safrani B.,Barillot E., Thiery  JP (2008)  High resolution mapping of DNA breakpoints to define true recurrences among ipsilateral breast cancers. J. Natl. Cancer. Inst. 100:48-58.
Name Jean-Paul THIERY
Affiliations Senior Principal Investigator, Cancer Science Institute of Singapore, NUS
Principal Investigator, Institute of Molecular and Cell Biology, A*STAR
Email csitjp[at]nus.edu.sg

Education

Institute Degree (if applicable) Year(s)
University Louis Pasteur, Strasbourg (France) 1964 – 1970
Mathematics-Physics-Chemistry Competitive examination, Ecole Nationale Supérieure de Chimie de Strasbourg 1965
Crystallography, General Chemistry, Mineral Chemistry, Experimental Physics 1966
Organic Chemistry, Industrial Chemistry, General Chemistry 1967
Masters in Physical Chemistry Engineering Diploma in Chemistry (Ecole Nationale Supérieure Chimie Strasbourg), placed first in the year. 1968
Diploma Organic Chemistry of Natural Substances 1968
Doctorat d’Etat Thesis, Institut Jacques Monod, Paris 1974

Professional Experience

Senior Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore 2008 – Present
Principal Investigator , Institute of Molecular Cell Biology (IMCB), A*STAR 2007 – Present
Chief Scientific Officer, Experimental Therapeutic Centre, A*STAR 2007 – Present
Adjunct Professor of Pathology, National University of Singapore 2007 – Present
Deputy Director, Institute of Molecular Cell Biology (IMCB), A*STAR 2007 – 2011
Director Department of Translational Research – Medical division Institut Curie 2003 – 2006
Scientific Officer Ministry of Research and Technology 2003 – 2006
Director of Research CNRS Exceptional Class 1999
Director of the laboratory of ‘Subcellular Structure and Cellular Dynamics’ of the CNRS and the Institut Curie, Paris 1995 – 2003
Director of Research CNRS First Class 1989
Director of the Laboratory of Physiopathology of Development of the CNRS and Ecole Normale Supérieure, Paris 1987 – 1994
Director of Research CNRS, Institute of Embryology, Nogent sur Marne, France 1982 – 1987
Senior Research Associate CNRS, Institute of Embryology, CNRS and the Collège de France, Nogent sur Marne, France 1978 – 1982
Research Associate, The Rockefeller University, New York 1977
Fogarty Postdoctoral Fellowship (NIH) 1976
Fellow of the International Center for Cancer Research, Lyon, France 1975
Postdoctoral fellow, laboratory of Professor Gerald M. Edelman, The Rockefeller University, New York 1975 – 1977
Research position, CNRS, Institut Jacques Monod, Paris 1970 – 1974
Research position at the Centre National de la Recherche Scientifique (CNRS) in the laboratory of Dr. Bernardi, Institute of Macromolecular Substances, Strasbourg, France 1968 – 1970

Ruby Yun-Ju HUANG

MD, PhD
Senior Research Fellow

Her current research interest is on the plasticity of ovarian surface epithelium, ovarian cancer stem cells, and personalized and translational medicine of epithelial ovarian cancer.

Tony TAN Tuan Zea

Senior Research Scientist

a. Integrative analysis of molecular subtype.
b. Quantitative modelling of Epithelial Mesenchymal Transition
c. Gene Expression database

CHUNG Vin Yee

Research Fellow

To study the potential roles of Discoidin Domain Receptor 1 and Grainyhead-like 2 in Epithelial-Mesenchymal Transition in Epithelial Ovarian Cancer.

Mohammad ASAD

Research Assistant

My work is focused on identifying mechanism of regulation and function of Wnt signalling in normal and cancer stem cells. I’m studying the role of a Wnt receptor in Ovarian cancer that drives to their stemness.

Katty KUAY Kuee Theng

Research Assistant

To study the reversal of Epithelial-Mesenchymal Transition(EMT) in ovarian cancer cells.

YE Jieru

Senior Laboratory Executive

To study the underlying function of TP53 in Epithelial Mesenchymal Transition.

Jane ANTONY

PhD Student

Role of AXL and BMPR1A on Epithelial Mesenchymal Transition.