NG Siok Bian

Being a histo-cytopathologist with speciality training in haematolymphoid and molecular pathology, my research interest is to apply this knowledge and to conduct in-depth study into the pathobiology and molecular mechanisms in haematolymphoid malignancies. In the process, I hope the basic research can be translated into human models for diagnostic, prognostic or therapeutic purposes. My training in histopathology, immunohistochemistry and molecular pathology facilitates tissue-based research and validation of novel biomarkers on clinical samples, which is important for translational research.

EBV-associated T/NK lymphoproliferative disorders are an important group of diseases because they are prevalent in Asia and clinical outcome is generally dismal as there are no reliable prognostic markers and effective therapy is lacking. The pathobiology of EBV-associated T/NK lymphomas is poorly understood and the role of EBV in the oncogenesis is yet to be established. Hence, it is important to conduct in-depth study into the pathogenesis and molecular mechanisms of these tumours.

In the last few years, Dr Ng’s research focus has been on EBV-associated T/NK-cell lymphoproliferative disorders, and in particular, extranodal NK/T cell lymphoma (NKTCL). Using a combinational analytical approach via gene and miRNA expression profiling on paraffin embedded tissue samples, she has uncovered the molecular signatures and important oncogenic pathways in NKTCL, and identified novel biomarkers and potential therapeutic targets. The long term goal is to delineate and validate key biomarkers and oncogenic pathways in NKTCL and identifying molecular subsets of prognostic and clinical importance.

Selected Publications:

  1. Yan J, Ng SB, Tay JL, Lin B, Koh TL, Tan J, Selvarajan V, Liu SC, Bi C, Wang S, Choo SN, Shimizu N, Huang G, Yu Q, Chng WJ. EZH2 overexpression in natural killer /T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood. 2013 Mar 25. [Epub ahead of print]. PMID:23529930
  2. Panneerselvam P, Singh LP, Selvarajan V, Chng WJ, Ng SB, Tan NS, Ho B, Chen J, Ding JL. T-cell death following immune activation is mediated by mitochondria-localized SARM. Cell Death Differ. 2013 Mar;20(3):478-89 [Epub ahead of print] PubMed PMID: 23175186.
  3. Tan SY, Chuang SS, Tang T, Tan L, Ko YH, Chuah KL, Ng SB, Chng WJ, Gatter K, Loong F, Liu YH, Hosking P, Cheah PL, Teh BT, Tay K, Koh M, Lim ST. Type II EATL (Epitheliotropic Intestinal T-cell Lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype. Leukemia. 2013 Feb 12. doi: 10.1038/leu.2013.41. [Epub ahead of print] PMID:23399895
  4. Croxford JL, Tang ML, Pan MF, Huang CW, Kamran N, Phua CM, Chng WJ, Ng SB, Raulet DH, Gasser S. ATM-dependent spontaneous regression of early Eμ-myc-induced murine B cell leukemia depends on NK and T cells. Blood. 2013 Jan 24. [Epub ahead of print] PMID:23349395
  5. Tse E, Gill H, Loong F, Kim SJ, Ng SB, Tang T, Ko YH, Chng WJ, Lim ST, Kim WS, Kwong YL. Type II enteropathy associated T-cell lymphoma: a retrospective multi-center analysis from the Asia Lymphoma Study Group. Am J Hematol. 2012 Jul;87(7):663-8. Epub 2012 May 28.
  6. Ng SB, Yan J, Huang G, Selvarajan V, Tay JL, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng WJ. Dysregulated microRNAs affect pathways and targets of biological relevance in nasal-type natural killer/T-cell lymphoma. Blood. 2011 Nov 3;118(18):4919-29. Epub 2011 Sep 14.
  7. Chng WJ, Huang GF, Chung TH, Ng SB, Gonzalez-Paz N, Troska-Price T, Mulligan G, Chesi M, Bergsagel PL, Fonseca R. Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma. Leukemia. 2011 Jun;25(6):1026-35
  8. Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YL, Shimizu N, Kagami Y, Aozasa K, Salto-Tellez M, Chng WJ. Activated Oncogenic Pathways and Therapeutic Targets in Extranodal Nasal-Type NK/T Cell Lymphoma Revealed by Gene Expression Profiling. J Pathol. 2011 Mar;223(4):496-510
  9. Ng SB, Khoury JD. Epstein-Barr Virus in Lymphoproliferative Processes: An update for the diagnostic pathologist. Adv Anat Pathol 2009 Jan; 16(1):40-55
  10. Ng SB, Lai KW, Murugaya S, Lee KM, Loong SL, Fook-Chong S, Tao M, Sng I. Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol 2004;17(9):1097-1107
Name NG Siok Bian
Affiliations Principal Associate, Cancer Science Institute, NUS
Associate Professor, Department of Pathology, Yong Loo Lin Medical School, NUS
Senior Consultant, Department of Pathology, National University Hospital
Email siok_bian_ng[at]nuhs.edu.sg

Education

Institute Degree (if applicable) Year(s)
National University of Singapore MBBS 1995
Royal College of Pathologists of Australasia FRCPA 2002
National Cancer Institute/National Institute of Health, USA, Bethesda Visiting Fellow 2003

Professional Experience

Principle Associate, Cancer Science Institute of Singapore, NUS 2013 – present
Consultant, Department of Pathology, NUS 2007 – 2010
Consultant, Dept of Laboratory (Histopathology), KK Women’s and Children’s Hospital 2005 – 2007
Consultant, Dept of Pathology, Singapore General Hospital 2004 – 2005
Associate Consultant, Dept of Pathology, Singapore General Hospital 2002 – 2004

Viknesvaran SELVARAJAN

Research Assistant

Characterization of the biological and clinical relevance of RUNX genes in Natural Killer/T-Cell lymphoma.