Melissa Jane FULLWOOD

The Fullwood lab focuses on understanding the 3-dimensional organization of our DNA in the complex nucleus. Cancer genome sequencing has revealed that many factors associated with 3-dimensional genome organization are mutated in cancers. Our lab’s main hypothesis is that epigenetic factors, transcription factors, and non-coding RNA are mutated in cancer, leading to dysregulation of chromatin interactions and consequently, dysregulated mRNA and non-coding RNA. This suggests that therapies targeting epigenomics and RNA may have the potential to treat cancer. We study this hypothesis within the system of cancer, particularly leukemia and breast cancer.

Despite remarkable progress towards personalized human genome sequencing, much about the human genome and transcriptome remains unknown, yet potentially relevant clinically. Recently, tremendous advances in next-generation sequencing, big data analyses, and artificial intelligence have enabled new understanding of our genome and RNA biology. Towards this aim, our interests include (1) understanding chromatin interactions and RNA biology in cancer, and (2) development of machine learning and big data analyses in epigenomics and transcriptomics, to promote cancer precision medicine.

Selected Publications:

  1. Cao et al., Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions, Scientific Reports., 2017
  2. Fang and Fullwood, Roles, Functions and Mechanisms of Long Non-Coding RNAs in Cancer, Genomics Proteomics Bioinformatics, 2016
  3. Choy et al., A resource of ribosomal RNA-depleted RNA-Seq data from different normal adult and fetal human tissues, Scientific Data, 2015
  4. Babu and Fullwood, 3D genome organization in health and disease: emerging opportunities in cancer translational medicine, Nucleus, 2015
  5. The ENCODE Project Consortium. An Integrated Encyclopedia of DNA Elements in the Human Genome, Nature. 2012
  6. Djebali et al. Landscape of Transcription in Human Cells, Nature. 2012
  7. Fullwood, M.J., Lee, J., Lin, L., Li, G., Huss, M., Ng, P., Sung, W-K., Shenolikar, S. Next-generation Sequencing of Apoptotic DNA Breakpoints Reveals Association with Actively Transcribed Genes and Gene Translocations, PLoS ONE. 2011
  8. Li et al. Extensive promoter-centered interactions provide higher-order framework for transcription regulation in human cells, Cell. 2012
  9. Li, G.*, Fullwood, M.J.*, Han X.*, et al. ChIA-PET Tool for Comprehensive Chromatin Interaction Analysis with Paired-End Tag Sequencing, Genome Biology. 2010 *Co-first authors.
  10. Fullwood et al. The Oestrogen Receptor a-mediated Human Chromatin Interactome, Nature. 2009
Name Melissa Jane FULLWOOD
Affiliations Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore
Nanyang Assistant Professor, School of Biological Sciences, Nanyang Technological University
Email melissa.fullwood[at]nus.edu.sg
Website http://fullwoodlab.com/

Education

Institute Degree (if applicable) Year(s)
National University of Singapore, Singapore Ph.D. 2009
Stanford University, USA B.Sc.(Hons) 2005

Professional Experience

Lee Kuan Yew Post-Doctoral Fellow, A*STAR-Duke-NUS NRP 2010 – 2012
Adjunct Research Fellow, Department of Biochemistry, National University of Singapore 2011 – 2012
Adjunct Post-Doctoral Fellow, Genome Institute of Singapore 2011 – 2012
Post-Doctoral Fellow, Duke-NUS 2009 – 2010
Research Fellow, Genome Institute of Singapore 2009
Research Officer, Genome Institute of Singapore 2005 – 2006

Luay ASWAD

Research Fellow
csila[at]nus.edu.sg

Computational analysis of chromatin topology and transcriptomic variation in leukemia and breast cancer.

…………………………………………………………………………………..

Deepak BABU

Research Fellow
csideb[at]nus.edu.sg

Investigation of chromatin interactions in the pathogenesis of leukaemia.

Sukru GULLUOGLU

Research Fellow
csisukr[at]nus.edu.sg

The effects of the relationship between non-coding RNAs and chromatin interactions on cancer progression.

Sambhavi

Research Fellow
csisam[at]nus.edu.sg

Understand the mechanism of chromatin topology alteration in breast carcinoma.

Eun Myoung SHIN

Research Fellow
csieunm[at]nus.edu.sg

Novel NFkB Regulators in Inflammation and Cancer (Collaboration with Prof. Vinay Tergaonkar at IMCB, A*STAR).

CAO Fan

Research Assistant
caofan[at]nus.edu.sg

Machine learning to predict chromatin interactions in cancer.

GOH Yufen

Senior Laboratory Executive
csigy[at]nus.edu.sg

To understand RNA biology and therapeutics in haematopoiesis and leukemia under the RNA Epigenomic Core.

FAM Wee Nih @ Winnie Fam

Laboratory Executive
csifwnw[at]nus.edu.sg

To understand RNA biology and therapeutics in haematopoiesis and leukemia under the RNA Epigenomic Core.

LOH Yan Ping

Laboratory Executive
csilohy[at]nus.edu.sg

Characterizing chromatin interactions in cancer.

TNG Jia Qi

Laboratory Executive
csitjq[at]nus.edu.sg

Characterizing chromatin interactions in cancer.

A*STAR/SNAS Young Scientist Award 2014
National Research Foundation (NRF) Fellowship 2013
A*STAR Phillip Yeo Prize for Outstanding Achievement in
Research (Biomedical)
2011
Regional Winner (International), GE & Science Prize
for Young Life Scientists
2010
Lee Kuan Yew Post-Doctoral Fellowship 2010
L’Oreal-UNESCO for Women in Science Singapore National
Fellowship
2009
A*STAR National Science Scholarship (A*STAR NSS PhD) 2006
Phi Beta Kappa 2005
A*STAR National Science Scholarship (A*STAR NSS BS) 2002