Latest @ CSI.

April 7, 2026

NMRC CS-IRG Grant Award – Prof. Chng Wee Joo

CSI Singapore Principal Investigator, Prof. Wee Joo Chng has been awarded the NMRC Clinician Scientist - Individual Research Grant (CS-IRG) for a groundbreaking project:🧬“The Role of Nutrient as a Driver...

April 6, 2026

NUSMed Trailblazer Research Series: “Pioneering Global Impact in Cancer Research” by CSI Singapore Director, Prof. Ashok Venkitaraman

What does it mean to pioneer global impact in cancer research? In this video, CSI Singapore Director, Prof. Ashok Venkitaraman reflects on discoveries in genome stability and the BRCA2 gene, and...

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Learned Conformational Space and Pharmacophore into Molecular Foundational Model

A key challenge in AI-driven drug discovery is moving beyond molecular analysis to enable chemically meaningful molecular design. In a newly published study in Advanced Science, researchers led by Senior […]

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying […]

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Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population A Randomized Clinical Trial (JAMA Internal Medicine, Nov 2025)

Authors Soo-Chin Lee, Sasidharan Swarnalatha Lucky, Junxian Zhu, Samuel Ow, Lukas Loh, Jun Hui Tan, Siew Eng Lim, Zarinah Hairom, Shivan Mehta 6, Bee-Choo Tai, Boon-Cher Goh Abstract Led by […]

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia […]

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr. […]

🚨 New Milestone in Cancer Research and Precision Medicine 🚨

CSI Singapore and Next&Bio Launch Joint Organoid Research Laboratory at NUS We are excited to announce the launch of a joint organoid research laboratory by Next&Bio and the Cancer Science […]

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability (Molecular Cell 2025)

Michael A. Longo1 ∙ Syed Moiz Ahmed2,10 ∙ Yue Chen3,10 ∙ Chi-Lin Tsai1,10 ∙ Sarita Namjoshi1 ∙ Runze Shen1 ∙ Zamal Ahmed1 ∙ Xiaoyan Wang1 ∙ Rajika L. Perera4 ∙ […]

A Multi-task Domain-adapted Model to Predict Chemotherapy Response from Mutations in Recurrently Altered Cancer Genes (iScience, March 2025)

Aishwarya Jayagopal1, 7 ∙ Robert J. Walsh2,7 ∙ Krishna Kumar Hariprasannan1 ∙ Ragunathan Mariappan1 ∙ Debabrata Mahapatra6 ∙ Patrick William Jaynes3 ∙ Diana Lim4 ∙ David Shao Peng Tan2,3,5 ∙ Tuan Zea Tan3 ∙ Jason J. Pitt3 ∙ Anand D. Jeyasekharan2,3 Vaibhav Rajan1, 8 1. Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore 117417, Singapore […]

The ADAR1-Regulated Cytoplasmic dsRNA-Sensing Pathway is A Novel Mechanism of Lenalidomide Resistance in Multiple Myeloma (Blood, March 2025)

Mun Yee Koh 1, Tae-Hoon Chung 1, Nicole Xin Ning Tang 1, Sabrina Hui Min Toh 1, Jianbiao Zhou 1, Tze King Tan 1, Leilei Chen 1,2, Wee Joo Chng […]

Pembrolizumab With or Without Bevacizumab in Platinum-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Randomized, Open-Label, Phase 2 Trial (The Lancet Oncology, Feb 2025)

Wan-Qin Chong, MBBS a ∙ Jia-Li Low, MBBS a ∙ Joshua K Tay, PhD b,d ∙ Thi Bich Uyen Le, BSca ∙ Grace Shi-Qing Goh, BSc g ∙ Kenneth Sooi, MBBS a ∙ Hui-Lin Teo, MBBS h ∙ Seng-Wee Cheo, MD a ∙ Regina Tong-Xin Wong, BSc g ∙ Jens Samol, MD h,j,k ∙ Ming-Yann Lim, MBBS i ∙ Hao Li, MBBS i ∙ Niranjan Shirgaonkar, MSc l ∙ Shumei Chia, PhD l ∙ Lingzhi Wang, PhD f,g ∙ Anil Gopinathan, MBBS c ∙ Donovan Kum-Chuen Eu, MBBS b ∙ Raymond King-Yin Tsang, MBChB b,d ∙ Prof Kwok-Seng Loh, MBBS b,d ∙ Prof Han-Chong Toh, MBBS m ∙ Nicholas Syn, MBBSe ∙ Li-Ren Kong, PhD f,g ∙ Ramanuj Dasgupta, PhD l ∙ Bee-Choo Tai, PhD n ∙ Yaw-Chyn Lim, PhD […]

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